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Chopping and Changing: the Evolution of the Flavin-dependent Monooxygenases

Autor: Janet M. Thornton, María Laura Mascotti, Roman A. Laskowski, Nicholas Furnham, Maximiliano Juri Ayub

Publikováno v: Journal of Molecular Biology

Flavin-dependent monooxygenases play a variety of key physiological roles and are also very powerful biotechnological tools. These enzymes have been classified into eight different classes (A–H) based on their sequences and biochemical features. By

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d728f76f2eb8bb469d05a7dd6349b782
https://pubmed.ncbi.nlm.nih.gov/27423402

Structural and Mutational Analyses of Aspergillus fumigatus SidA: A Flavin-Dependent N-hydroxylating Enzyme

Autor: Fedkenheuer, Michael Gerald

SidA from Aspergillus fumigatus is an N-hydroxylating monooxygenase that catalyzes the committed step in siderophore biosynthesis. This gene is essential for virulence making it an excellent drug target. In order to design an inhibitor against SidA a

Externí odkaz: http://hdl.handle.net/10919/76837
http://scholar.lib.vt.edu/theses/available/etd-08082012-192654/

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An unprecedented NADPH domain conformation in lysine monooxygenase NbtG provides insights into uncoupling of oxygen consumption from substrate hydroxylation.

Autor: Binda C; From the Department of Biology and Biotechnology, University of Pavia, Pavia 27100, Italy., Robinson RM; Department of Biochemistry, Virginia Tech, Blacksburg, Virginia 24061, and., Martin Del Campo JS; Department of Biochemistry, Virginia Tech, Blacksburg, Virginia 24061, and., Keul ND; Department of Biochemistry, Virginia Tech, Blacksburg, Virginia 24061, and., Rodriguez PJ; Department of Biochemistry, Virginia Tech, Blacksburg, Virginia 24061, and., Robinson HH; Biology Department, Brookhaven National Laboratory, Upton, New York 11973., Mattevi A; From the Department of Biology and Biotechnology, University of Pavia, Pavia 27100, Italy, andrea.mattevi@unipv.it., Sobrado P; Department of Biochemistry, Virginia Tech, Blacksburg, Virginia 24061, and psobrado@vt.edu.

Publikováno v: The Journal of biological chemistry [J Biol Chem] 2015 May 15; Vol. 290 (20), pp. 12676-88. Date of Electronic Publication: 2015 Mar 23.