Can N-oxidation alleviate the energy-safety contradiction of energetic materials?

Autor: Yilin Cao, Weipeng Lai, Tao Yu, Yingzhe Liu, Bozhou Wang

Publikováno v: FirePhysChem, Vol 1, Iss 1, Pp 27-32 (2021)

The introduction of the N-oxide functional group to the heterocyclic structure is deemed as an effective strategy to construct highly energetic and lowly sensitive materials. Nevertheless, the detailed influence of N-oxidation on the detonation perfo

Externí odkaz: https://doaj.org/article/2718a71bd8ee46379d1e4e6e82d88dd8

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Determination of Metoclopramide Hydrochloride in Pharmaceutical Formulations using N-Oxidation Caroate

Autor: Valery Petrovich Moroz, Mykola Blazheyevskiy, Deghinmotei UgbenboAlfred-Ugbenbo, O. O. Mozgova

Publikováno v: Turkish Journal of Pharmaceutical Sciences. 19:589-594

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8460ef7c0efbae6e6c89d3a28898b914
https://doi.org/10.4274/tjps.galenos.2021.33733

Metabolic N-Dealkylation and N-Oxidation as Elucidators of the Role of Alkylamino Moieties in Drugs Acting at Various Receptors

Autor: Babiker M. EH-Haj

Publikováno v: Molecules, Vol 26, Iss 7, p 1917 (2021)

Metabolic reactions that occur at alkylamino moieties may provide insight into the roles of these moieties when they are parts of drug molecules that act at different receptors. N-dealkylation of N,N-dialkylamino moieties has been associated with ret

Externí odkaz: https://doaj.org/article/ce9f5abc94d34cbabb78cb6c63d6dba0

Fatty acid acylated peptide therapeutics: discovery of omega-n oxidation of the lipid chain as a novel metabolic pathway in preclinical species

Autor: Simone Esposito, Alain Krick, Olivier Pasquier, Fabrice Bonche, Raffaele Ingenito, Paola Magotti, Elisabetta Bianchi, Edith Monteagudo, Mariana Gallo, Daniel Oscar Cicero, Laura Orsatti, Maria Veneziano, Fulvia Caretti, Riccardo Mele, Daniela Roversi, Nadia Gennari, Denis Brasseur, Laurence Gauzy-Lazo, Olivier Duclos, Christine Mauriac, Stephane Illiano, Sergio Mallart

Publikováno v: Journal of Pharmaceutical and Biomedical Analysis
Journal of Pharmaceutical and Biomedical Analysis, 2023, 227, pp.115256. ⟨10.1016/j.jpba.2023.115256⟩

International audience; We recently described C18 fatty acid acylated peptides as a new class of potent long-lasting single-chain RXFP1 agonists that displayed relaxin-like activities in vivo. Early pharmacokinetics and toxicological studies of these

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe48f7e018f9c4ba38832ba51bf5e8f5
https://hdl.handle.net/2108/313607