Zobrazeno 1 - 10 of 819 pro vyhledávání: '"N of 1 trial"'
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N-of-1 Clinical Trials: A Scientific Approach to Personalized Medicine for Patients with Rare Retinal Diseases Such as Retinitis Pigmentosa
Autor: Marco A. Zarbin, Gary D. Novack
Publikováno v: Journal of Ocular Pharmacology and Therapeutics. 37:495-501
N-of-1 trials are randomized, prospective, controlled, multiple crossover trials in a single patient. Effects of one or more treatments are studied by following individual patients who receive alternative treatments (eg, therapeutic intervention). Su
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b5be0a9dc601477ea3c5b6314931ec0
https://doi.org/10.1089/jop.2021.0059
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3
Individual Postprandial Glycemic Responses to Diet in n-of-1 Trials: Westlake N-of-1 Trials for Macronutrient Intake (WE-MACNUTR)
Autor: Min Yang, Yunyi Tian, Zelei Miao, Wanglong Gou, Ju-Sheng Zheng, Yuanqing Fu, Jose M. Ordovas, Yue Ma
Publikováno v: The Journal of Nutrition. 151:3158-3167
Background The role of different types and quantities of macronutrients on human health has been controversial, and the individual response to dietary macronutrient intake needs more investigation. Objectives We aimed to use an 'n-of-1' study design
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9383991ae97f3fdd165a08b205057163
https://doi.org/10.1093/jn/nxab227
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5
Status of N-of-1 Trials in Chronic Pain Management: A Narrative Review
Autor: Yin Chen, Fang Wang, Zichan Cui, Fengxian Li, Wanying He
Publikováno v: Pain and Therapy
N-of-1 trials are randomized controlled clinical trials conducted exclusively on a single patient. The ultimate aim of N-of-1 trials is to optimize a strategy in a particular individual. Chronic pain is a common but refractory clinical problem. Its d
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8180b8dc10634d4282e6ba1e560eae8b
http://europepmc.org/articles/PMC8586287
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Exploring Symptom Fluctuations and Triggers in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Using Novel Patient-Centred N-of-1 Observational Designs: A Protocol for a Feasibility and Acceptability Study
Autor: Suzanne McDonald, Geoffrey Mitchell, Samuel X. Tan, James McGree, Shamima Banu, Mieke L van Driel, Jane Nikles
Publikováno v: The Patient - Patient-Centered Outcomes Research. 15:197-206
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a chronic condition of unknown aetiology associated with a range of disabling symptoms, including post-exertional malaise, chronic fatigue, musculoskeletal pain, orthostatic intolerance,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7ba3eab3b8b855f4c1419ba8e0c1c2a
https://doi.org/10.1007/s40271-021-00540-0
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7
Racial and ethnic minority patient participation in N-of-1 trials: perspectives of healthcare providers and patients
Autor: Lyndonna Marrast, Joseph Conigliaro, Joan Duer-Hefele, Michael A Diefenbach, Camille Chan, Karina W. Davidson, Eun Ji Kim
Publikováno v: Per Med
Lay abstract Commonly, research studies seek to enroll large groups of individuals to test a new product or medication. However, the personalized trial/N-of-1 trial has a different goal. This is to focus on a single person and study their response to
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::779080e57d8b952cf404c9277a8d1899
https://doi.org/10.2217/pme-2020-0166
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Toward improving the specificity of perturbation-based training through assessment of dynamic balancing responses: a series of N-of-1 studies in subacute stroke
Autor: Nataša Bizovičar, Zlatko Matjacic, Andrej Olenšek, Marko Rudolf, Matjaž Zadravec, Nika Goljar
Publikováno v: International Journal of Rehabilitation Research. 44:276-281
Perturbation-based balance training (PBT) has been shown to improve reactive balancing abilities in chronic stroke. To inform future investigations in the subacute phase of stroke, the objective of this series of N-of-1 studies was to investigate the
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cf4896bca4f8831b131c5c9e4e9eae4
https://doi.org/10.1097/mrr.0000000000000482
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The Double Stitch Everting Technique in the End-to-Side Microvascular Anastomosis
Autor: Ruben Dammers, Ramona C. Vinasi, Maximilian George Dindelegan, G. Dindelegan, Victor Volovici, Alex Orădan
Publikováno v: Journal of Reconstructive Microsurgery, 37(5), 421-426. Thieme Medical Publishers
Background The double stitch everting (DSE) technique, in which time is won by leaving the needle inside the vessel wall in-between stitching, is a modification of the end-to-side (ETS) anastomosis in the interest of reducing anastomosis time. This e
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8749d7fb4156c36bd312a6f81cfb81fe
https://doi.org/10.1055/s-0040-1718548
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Using a multistakeholder collaboratory and patient surveys to inform the conduct of personalized (N-of-1) trials
Autor: Ian M. Kronish, Naihua Duan, Dallas Wood, Elizabeth Cohn, Karina W. Davidson, Lilly Derby, Ying Kuen K. Cheung, Tara St. Onge, Nathalie Moise, Joan Duer-Hefele
Publikováno v: Health Psychology. 40:230-241
OBJECTIVE Personalized trials have the potential to improve the precision of treatment selection and foster patient involvement in clinical decision making. Little is known about the attitudes of patients with multimorbidities. To address this, stake
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5e38e5dfdc54ec17eb466c6ebf63354
https://doi.org/10.1037/hea0001058
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