Výsledky vyhledávání

Mitochondrial DNA Variation and Heteroplasmy in Monozygotic Twins Clinically Discordant for Multiple Sclerosis

Autor: Jörn Walter, N Y Souren, Lisa Ann Gerdes, Tania Kümpfel, Thomas Klopstock, Reinhard Hohlfeld, Pavlo Lutsik

Publikováno v: Human mutation 37(8), 765-775 (2016). doi:10.1002/humu.23003

We examined the debated link between mitochondrial DNA (mtDNA) variation and multiple sclerosis (MS) using 49 monozygotic (MZ) twin pairs clinically discordant for MS, which enables to associate de novo mtDNA variants, skewed heteroplasmy, and mtDNA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32ef2e0f74349d88fd0cb743fe803fd8
https://doi.org/10.1002/humu.23003

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DNA Methylation Signatures of a Large Cohort Monozygotic Twins Clinically Discordant for Multiple Sclerosis

Autor: Dieter Weichenhan, Gilles Gasparoni, Tania Kümpfel, Christoph Plass, Lisa Ann Gerdes, Pavlo Lutsik, Reinhard Hohlfeld, Abdulrahman Salhab, Eduardo Beltrán, Jörn Walter, N Y Souren

Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system with a modest concordance rate in monozygotic twins that strongly argues for involvement of epigenetic factors. We observe in 45 MS discordant monozygotic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60ed509700ab618968bfe7fd4aa98a37
https://doi.org/10.1101/381822

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DNA methylation studies on imprinted loci in a male monozygotic twin pair discordant for Beckwith-Wiedemann syndrome

Autor: K. D. Zang, Jörn Walter, J Meng-Hentschel, D. Leitner, Sascha Tierling, N Y Souren, S. Reither, B Oehl-Jaschkowitz

Publikováno v: Clinical Genetics, 79(6), 546-553. Wiley

Tierling S, Souren NY, Reither S, Zang KD, Meng-Hentschel J, Leitner D, Oehl-Jaschkowitz B, Walter J. DNA methylation studies on imprinted loci in a male monozygotic twin pair discordant for Beckwith–Wiedemann syndrome. Beckwith–Wiedemann syndrom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10a121add37f19c5d3eeef50bb4778d4
https://doi.org/10.1111/j.1399-0004.2010.01482.x

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Common SNPs in LEP and LEPR associated with birth weight and type 2 diabetes-related metabolic risk factors in twins

Autor: Ruth J. F. Loos, Robert Vlietinck, Gaston Beunen, Hubert J.M. Smeets, N Y Souren, Anja Steyls, Maurice P. Zeegers, Marij Gielen, Aimee D C Paulussen, Catherine Derom, Alphons P. M. Stassen, Joep P.M. Geraedts, Robert Fagard

Publikováno v: International Journal of Obesity, 32, 1233-1239. Nature Publishing Group

Children born small for gestational age are at increased risk of developing type 2 diabetes in adulthood. The satiety signal leptin that regulates food intake and energy expenditure might be a possible molecular link, as umbilical cord leptin levels

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2183473767006c340c76d523f7977089
https://doi.org/10.1038/ijo.2008.68

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Twin-Specific Intrauterine ‘Growth’ Charts Based on Cross-Sectional Birthweight Data

Autor: Patrick J. Lindsey, N Y Souren, Robert Derom, Robert Vlietinck, Marij Gielen, Ruth J. F. Loos, Maurice P. Zeegers, Aimee D C Paulussen, Jan G. Nijhuis, Catherine Derom

Publikováno v: Twin Research and Human Genetics, 11(2), 224-235. Australian Academic Press

The assessment of fetal growth is an essential component of good antenatal care, especially for twins. The aims of this study are to develop twin-specific intrauterine 'growth' charts, based on cross-sectional birthweight data, for monochorionic and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d94ba61fe80f4c71265004e558b38ccf
https://doi.org/10.1375/twin.11.2.224

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Anthropometry, carbohydrate and lipid metabolism in the East Flanders Prospective Twin Survey: linkage of candidate genes using two sib-pair based variance components analyses

Autor: N Y Souren, Alphons P. M. Stassen, Robert Vlietinck, Ruth J. F. Loos, Anja Steyls, Aimee D C Paulussen, Rob G J H Janssen, Jeroen Aerssens, Catherine Derom, Marij Gielen, Maurice P. Zeegers, Gaston Beunen, Robert Fagard

Publikováno v: Twin Research and Human Genetics, 11(5), 505-16. Australian Academic Press

Insulin resistance and obesity are underlying causes of type 2 diabetes and therefore much interest is focused on the potential genes involved. A series of anthropometric and metabolic characteristic were measured in 240 MZ and 112 DZ twin pairs recr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69ac0d5f70fe7ef07114bfa99cb8d57f
https://doi.org/10.1375/twin.11.5.505

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Anthropometry, carbohydrate and lipid metabolism in the East Flanders Prospective Twin Survey: heritabilities

Autor: Robert Vlietinck, N Y Souren, Robert Fagard, Ruth J. F. Loos, Aimee D C Paulussen, Maurice P. Zeegers, Gaston Beunen, Marij Gielen, Catherine Derom

Publikováno v: Diabetologia
Diabetologia, 50(10), 2107-2116. Springer, Cham

Aims/hypothesis We determined the genetic contribution of 18 anthropometric and metabolic risk factors of type 2 diabetes using a young healthy twin population. Methods Traits were measured in 240 monozygotic (MZ) and 138 dizygotic (DZ) twin pairs ag

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe8564bf198a733e49d2aa48c7ba4afa
https://doi.org/10.1007/s00125-007-0784-z

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Adult monozygotic twins discordant for intra-uterine growth have indistinguishable genome-wide DNA methylation profiles

Autor: Matthias Riemenschneider, Maurice P. Zeegers, Sascha Tierling, Gilles Gasparoni, N Y Souren, Jasmin Gries, Catherine Derom, Pavlo Lutsik, Jean-Pierre Fryns, Jörn Walter

Publikováno v: Genome Biology, 14(5):44. BioMed Central Ltd
Genome Biology

BACKGROUND: Low birth weight is associated with an increased adult metabolic disease risk. It is widely discussed that poor intra-uterine conditions could induce long-lasting epigenetic modifications, leading to systemic changes in regulation of meta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f09e8bed121c32aaa940fed9ab74bc1d
https://lirias.kuleuven.be/handle/123456789/401996

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