Zobrazeno 1 - 10
of 40
pro vyhledávání: '"N Y Fan"'
Autor:
Kolja Schleich, Julia Kase, Jan R. Dörr, Saskia Trescher, Animesh Bhattacharya, Yong Yu, Elizabeth M. Wailes, Dorothy N. Y. Fan, Philipp Lohneis, Maja Milanovic, Andrea Lau, Dido Lenze, Michael Hummel, Bjoern Chapuy, Ulf Leser, Maurice Reimann, Soyoung Lee, Clemens A. Schmitt
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Therapy-induced senescence reflects a biological effector principle that is underrecognized in lesion-focused cancer precision medicine. Here the authors utilize mouse lymphoma genetics to functionally dissect senescence and cross-species apply a nov
Externí odkaz:
https://doaj.org/article/05c76f30d3fb41ad9a1c454ca0327848
Akademický článek
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Autor:
Dorothy N. Y. Fan, Clemens A. Schmitt
Publikováno v:
Nature Cancer. 3:1279-1281
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::25c681217922e6cac7f884e92569af99
https://doi.org/10.1038/s43018-022-00455-1
https://doi.org/10.1038/s43018-022-00455-1
Autor:
Yong Yu, Clemens A. Schmitt, Dorothy N. Y. Fan, Jingjing Qi, Claudia Wöß, Mario Mairhofer, Eva Dovjak
Publikováno v:
Journal of visualized experiments : JoVE. (185)
Chemotherapeutic drugs can induce irreparable DNA damage in cancer cells, leading to apoptosis or premature senescence. Unlike apoptotic cell death, senescence is a fundamentally different machinery restraining propagation of cancer cells. Decades of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a9b164d8190135b5a438a99c723f4f8
https://pubmed.ncbi.nlm.nih.gov/35913198
https://pubmed.ncbi.nlm.nih.gov/35913198
Autor:
Belma Nazli Güllü, Dorothy N. Y. Fan, Dennis Kobelt, Margarita Mokrizkij, Janice Smith, Clemens A. Schmitt, Ulrike Stein
Publikováno v:
Cancer Research. 83:B045-B045
Senescence is considered a safeguard program against cancer progression. However, recent studies revealed that these cells, reprogrammed in a senescence-associated fashion to express stemness transcripts, may occasionally re-enter the cell cycle, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3b9d071f17d7655a683eb4c65d7676e7
https://doi.org/10.1158/1538-7445.metastasis22-b045
https://doi.org/10.1158/1538-7445.metastasis22-b045
Autor:
Markus Landthaler, Bernd Lamprecht, Riad Ghanem, Amjad Khan, Michael Mülleder, Maurice Reimann, Herta Steinkellner, Soyoung Lee, Emanuel Wyler, Mario Mairhofer, Wolfram Hoetzenecker, Paulina Richter-Pechanska, Séverine Kunz, Josef Tomasits, Rupert Langer, Kristina Dietert, Michael Schotsaert, Maria Pammer, Carles Martínez-Romero, Susanne Kimeswenger, Theresa C. Firsching, Jakob Trimpert, Melissa Uccellini, Achim D. Gruber, Bettina Purfürst, Adolfo García-Sastre, Clemens A. Schmitt, Reinhard Motz, Nikolaus Osterrieder, Anna Habringer, Markus Ralser, Julia Adler, Fahad Benthani, Martin Schönlein, Andrea Lau, Daniela Niemeyer, Christian Drosten, Dimitri Belenki, Dorothy N. Y. Fan, Roland Eils, Francesco Di Pierro, Lea Kausche, Gagandeep Singh, Christian Paar, Edward Georg Michaelis, Helmut J. F. Salzer, Yong Yu, Sabine Kaltenbrunner
Publikováno v:
Nature. 599(7884)
Derailed cytokine and immune cell networks account for the organ damage and the clinical severity of COVID-19 (refs. 1–4). Here we show that SARS-CoV-2, like other viruses, evokes cellular senescence as a primary stress response in infected cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12c2767d2ebf83ab4c0372d59b825eab
https://pubmed.ncbi.nlm.nih.gov/34517409
https://pubmed.ncbi.nlm.nih.gov/34517409
Autor:
Ana-Maria Gätjens-Sanchez, Paulina Richter-Pechanska, Maurice Reimann, Liam Childs, Ruth Flümann, Anna Dolnik, Timon Pablo Hick, Lars Bullinger, Dorothy N. Y. Fan, Dorothee Childs, Kolja Schleich, Clemens A. Schmitt, Jens Schrezenmeier, Sven Maßwig, Andreas Rosenwald, Sophy Denker, Hans Christian Reinhardt, Philipp Lohneis, Antonia Busse, Gero Knittel, Xiurong Cai
Publikováno v:
Blood. 137(20)
Aberrant B-cell receptor/NF-κB signaling is a hallmark feature of B-cell non-Hodgkin lymphomas, especially in diffuse large B-cell lymphoma (DLBCL). Recurrent mutations in this cascade, for example, in CD79B, CARD11, or NFKBIZ, and also in the Toll-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7d2ea35f4b519f83104caf014106259
https://pubmed.ncbi.nlm.nih.gov/33232972
https://pubmed.ncbi.nlm.nih.gov/33232972
Autor:
Dorothy N Y, Fan, Clemens A, Schmitt
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1896
A cell's genomic integrity is at risk when DNA-damaging stress, evoked by mitogenic oncogenes or genotoxic treatment modalities such as radiation or chemotherapy, apply. If the DNA repair machinery fails to fix the damaged site during a temporary cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::63700e3d353e457b6a849fab00e03e28
https://pubmed.ncbi.nlm.nih.gov/30474843
https://pubmed.ncbi.nlm.nih.gov/30474843
Autor:
Clemens A. Schmitt, Dorothy N. Y. Fan
Publikováno v:
Methods in Molecular Biology ISBN: 9781493989300
A cell's genomic integrity is at risk when DNA-damaging stress, evoked by mitogenic oncogenes or genotoxic treatment modalities such as radiation or chemotherapy, apply. If the DNA repair machinery fails to fix the damaged site during a temporary cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb628144773f5cbd0b005fc16f4fb63d
https://doi.org/10.1007/978-1-4939-8931-7_10
https://doi.org/10.1007/978-1-4939-8931-7_10
Autor:
Yong Yu, Inês Am Barbosa, Katharina Pardon, Andreas Trumpp, Dimitri Belenki, Hinrich Gronemeyer, Dorothy N. Y. Fan, Jan Dörr, Marco A. Mendoza-Parra, Maja Milanovic, Lora Dimitrova, Maurice Reimann, Marlen Metzner, Zhen Zhao, Tamara Kanashova, Dido Lenze, Clemens A. Schmitt, J. Henry M. Däbritz, Soyoung Lee, Michael Hummel, Johannes Zuber, Bernd Dörken, Gunnar Dittmar
Publikováno v:
Nature
Nature, Nature Publishing Group, 2018, 553 (7686), pp.96-100. ⟨10.1038/nature25167⟩
Nature, Nature Publishing Group, 2018, 553 (7686), pp.96-100. ⟨10.1038/nature25167⟩
Cellular senescence is a stress-responsive cell-cycle arrest program that terminates the further expansion of (pre-)malignant cells. Key signalling components of the senescence machinery, such as p16(INK4a), p21(CIP1) and p53, as well as trimethylati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5693bfb1cf0313dd752edd8c15b9dce4
https://hal.archives-ouvertes.fr/hal-02364397
https://hal.archives-ouvertes.fr/hal-02364397