Zobrazeno 1 - 10
of 17
pro vyhledávání: '"N Y, Lycke"'
Publikováno v:
Scandinavian Journal of Immunology. 53:13-23
Ga¨rdby E, Chen X-J, Lycke NY. Impaired CD40-Signalling in CD19-Deficient Mice Selectively AffectsTh2-Dependent Isotype Switching. Scand J Immunol 2001;53:13–23Activation of B lymphocytes involves binding of antigen to the specific receptor and si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ada1271be3567711393e255d17d44e1
https://doi.org/10.1046/j.1365-3083.2001.00824.x
https://doi.org/10.1046/j.1365-3083.2001.00824.x
Publikováno v:
The Journal of Immunology. 160:754-762
We found that feeding keyhole limpet hemocyanin (KLH) to CD8-deficient (CD8−/−) mice induced oral tolerance that was comparable in both magnitude and quality to that induced in wild-type (wt) mice. The tolerance was dose dependent, and only highe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1602eafef77065a49ea7c8950285877
https://doi.org/10.4049/jimmunol.160.2.754
https://doi.org/10.4049/jimmunol.160.2.754
Publikováno v:
The Journal of Immunology. 158:3936-3946
Cholera toxin (CT) is an exceptionally potent adjuvant but, unfortunately, also very toxic. Here we present a powerful new approach to separate toxicity from adjuvanticity by constructing a fusion protein that combines the enzymatically active choler
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9b0a145fa319d2fe4b24215e3fb2cad4
https://doi.org/10.4049/jimmunol.158.8.3936
https://doi.org/10.4049/jimmunol.158.8.3936
Publikováno v:
The Journal of Immunology. 155:2877-2887
Using normal and CD4 gene-targeted (CD4-/-) mice, we asked whether mucosal immune responses and IgA B cell differentiation require the presence of CD4+ T helper cells. We found that CD4-/- mice had numerous B cell germinal centers in Peyer's patches
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b2f4eccb3a5026aa01fdc78dfadb2064
https://doi.org/10.4049/jimmunol.155.6.2877
https://doi.org/10.4049/jimmunol.155.6.2877
Autor:
N Y Lycke
Publikováno v:
The Journal of Immunology. 150:4810-4821
In a recent study we provided evidence that isotype switching in LPS-stimulated murine B cells was greatly enhanced by cholera toxin (CT). We found that CT acted synergistically with IL-4 to promote IgG1 differentiation at the gene transcriptional le
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a88973c472dd8ffdf76862e2a1a8ef18
https://doi.org/10.4049/jimmunol.150.11.4810
https://doi.org/10.4049/jimmunol.150.11.4810
Autor:
N Y, Lycke, R, Coico
Publikováno v:
Current protocols in immunology.
The enzyme-linked immunospot (ELISPOT) assay for detection of single antibody-secreting cells has become the best alternative method to the conventional plaque-forming cell (PFC) assays. Among its several advantages are better antigen stability and s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ea6678461b913a1cbaa02cef2c5903ad
https://pubmed.ncbi.nlm.nih.gov/18432828
https://pubmed.ncbi.nlm.nih.gov/18432828
Publikováno v:
The Journal of Immunology. 145:2406-2414
Thy-1- T cells expressing CD4 and the alpha beta-TCR have been identified in murine lymphoid tissues. These cells are particularly prevalent in Peyer's patches (PP), representing 17 +/- 3% of PP CD4 T cells, whereas they are much less prevalent in sp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d69315fdf130cc01353f53b34e242f93
https://doi.org/10.4049/jimmunol.145.8.2406
https://doi.org/10.4049/jimmunol.145.8.2406
Publikováno v:
Scandinavian journal of immunology. 53(1)
Activation of B lymphocytes involves binding of antigen to the specific receptor and signalling through several membrane coreceptors, of which CD19 has been found to play a pivotal role as a response regulator. Although previous studies in CD19 gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7b85338fe8e4f346fc5e6db11bbb6c6e
https://pubmed.ncbi.nlm.nih.gov/11169202
https://pubmed.ncbi.nlm.nih.gov/11169202
Autor:
E, Gärdby, N Y, Lycke
Publikováno v:
European journal of immunology. 30(7)
CD19 exhibits a critical role as a response regulator in B cells, influencing activation, differentiation and survival. Accordingly, CD19-deficient mice largely lack B-1 cells, and their conventional B-2 cells are poor responders to thymus-dependent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1ab76fe6ce7ba21c894b75aa5d896a8d
https://pubmed.ncbi.nlm.nih.gov/10940875
https://pubmed.ncbi.nlm.nih.gov/10940875
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 162(4)
The ADP-ribosylating enterotoxins, cholera toxin (CT) and Escherichia coli heat-labile toxin, are among the most powerful immunogens and adjuvants yet described. An innate problem, however, is their strong toxic effects, largely due to their promiscu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b1685b9baa5027295a81470961c579a6
https://pubmed.ncbi.nlm.nih.gov/9973526
https://pubmed.ncbi.nlm.nih.gov/9973526