Zobrazeno 1 - 10
of 27
pro vyhledávání: '"N W Bunnett"'
Autor:
C E Degro, N N Jiménez-Vargas, H M Schincariol, Q K Tsang, M Guzman-Rodriguez, A E Lomax, D E Reed, C Stein, N W Bunnett, S J Vanner
Publikováno v:
Journal of the Canadian Association of Gastroenterology. 6:90-91
Background Adequate pain control in inflammatory bowel disease (IBD) can require opioids due to their high analgesic potency. The long-term use of opioids, however, is limited by the development of tolerance. This leads to reduced analgesic efficacy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ec0dcbdd5db36f089fdf65a71874a203
https://doi.org/10.1093/jcag/gwac036.277
https://doi.org/10.1093/jcag/gwac036.277
Autor:
C E Degro, N N Jiménez-Vargas, Q K Tsang, Y Yu, C Stein, N W Bunnett, A E Lomax, D E Reed, S Vanner
Publikováno v:
Journal of the Canadian Association of Gastroenterology. 5:61-62
Background Opioids provide effective pain relief during flares of inflammatory bowel disease but are limited by serious side effects. We showed that acute administration of a novel pH-sensitive opioid agonist, NFEPP, had potent analgesic effects in i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::56d63ccf9ff88788ff10d5d303119257
https://doi.org/10.1093/jcag/gwab049.052
https://doi.org/10.1093/jcag/gwab049.052
Publikováno v:
British journal of pharmacology. 171(5)
Bile acids (BAs) are digestive secretions that are necessary for the emulsification and absorption of dietary fats. Given the episodic nature of BA secretion and intestinal re-absorption, the circulating and tissue levels of BAs, like those of the gu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4328b3e09f6d2d56b694119969b4dd45
https://pubmed.ncbi.nlm.nih.gov/24111923
https://pubmed.ncbi.nlm.nih.gov/24111923
Publikováno v:
The Journal of Immunology. 154:4379-4389
T cell homing into extravascular sites requires penetration across the subendothelial basal lamina, a specialized nonfibrillar connective tissue structure that anchors endothelial cells to parenchymal surfaces. Herein, we show that normal human T cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::92310e2f31d4467e283e5e03748fcfff
https://doi.org/10.4049/jimmunol.154.9.4379
https://doi.org/10.4049/jimmunol.154.9.4379
Expression and function of the bile acid receptor GpBAR1 (TGR5) in the murine enteric nervous system
Autor:
D P, Poole, C, Godfrey, F, Cattaruzza, G S, Cottrell, J G, Kirkland, J C, Pelayo, N W, Bunnett, C U, Corvera
Publikováno v:
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. 22(7)
Bile acids (BAs) regulate cells by activating nuclear and membrane-bound receptors. G protein coupled bile acid receptor 1 (GpBAR1) is a membrane-bound G-protein-coupled receptor that can mediate the rapid, transcription-independent actions of BAs. A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5230398fd50d5cfddb60468c5a2e3606
https://pubmed.ncbi.nlm.nih.gov/20236244
https://pubmed.ncbi.nlm.nih.gov/20236244
Autor:
D. Roosterman, N. W. Bunnett
Publikováno v:
Handbook of Experimental Pharmacology ISBN: 9783642623424
Biological responses to agonists of G-protein coupled receptors are regulated by control of the interactions of receptors with signaling proteins and through control of the levels of receptors that are present at the cell surface. Agonist binding to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::af9bbdf46cfea226f84e6a4f667b4fb9
https://doi.org/10.1007/978-3-642-18891-6_5
https://doi.org/10.1007/978-3-642-18891-6_5
Autor:
L, de Garavilla, N, Vergnolle, S H, Young, H, Ennes, M, Steinhoff, V S, Ossovskaya, M R, D'Andrea, E A, Mayer, J L, Wallace, M D, Hollenberg, P, Andrade-Gordon, N W, Bunnett
Publikováno v:
British journal of pharmacology. 133(7)
Thrombin, generated in the circulation during injury, cleaves proteinase-activated receptor 1 (PAR1) to stimulate plasma extravasation and granulocyte infiltration. However, the mechanism of thrombin-induced inflammation in intact tissues is unknown.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9905ab83c5a659fd0ae47427b411d93f
https://pubmed.ncbi.nlm.nih.gov/11487506
https://pubmed.ncbi.nlm.nih.gov/11487506
Publikováno v:
Journal of neuroendocrinology. 13(3)
Agonist-induced endocytosis of somatostatin receptors determines subsequent cellular responsiveness to peptide agonist and influences somatostatin receptor scintigraphy, a technique to image various tumours. We examined the internalization of sst3HSV
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2850b1f65b317b3c28d6dd41ef71d2b8
https://pubmed.ncbi.nlm.nih.gov/11207943
https://pubmed.ncbi.nlm.nih.gov/11207943
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 295(1)
Trypsin and mast cell tryptase cleave within the extracellular N terminus of proteinase-activated receptor-2 (PAR-2), exposing a tethered ligand (SLIGRL) that binds and activates the cleaved receptor. We examined the neuronal expression of PAR-2 and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::709be1fecd8bd552dc1e361a1a2d3fd4
https://pubmed.ncbi.nlm.nih.gov/10992008
https://pubmed.ncbi.nlm.nih.gov/10992008
Publikováno v:
The Journal of comparative neurology. 423(3)
Substance P (SP) is the major endogenous ligand for neurokinin 1 (NK1) receptors and, together with acetylcholine, has an important role in motivated behaviors involving the limbic shell and motor core of the nucleus accumbens (NAc). To determine the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c0a88b9310a484b74b9ef2aa0eb96f35
https://pubmed.ncbi.nlm.nih.gov/10870089
https://pubmed.ncbi.nlm.nih.gov/10870089