Zobrazeno 1 - 7 of 7 pro vyhledávání: '"N W, Roehm"'
1
Pharmacology of LY315920/S-5920, [[3-(aminooxoacetyl)-2-ethyl-1- (phenylmethyl)-1H-indol-4-yl]oxy] acetate, a potent and selective secretory phospholipase A2 inhibitor: A new class of anti-inflammatory drugs, SPI
Autor: D W, Snyder, N J, Bach, R D, Dillard, S E, Draheim, D G, Carlson, N, Fox, N W, Roehm, C T, Armstrong, C H, Chang, L W, Hartley, L M, Johnson, C R, Roman, A C, Smith, M, Song, J H, Fleisch
Publikováno v: The Journal of pharmacology and experimental therapeutics. 288(3)
LY315920 is a potent, selective inhibitor of recombinant human, group IIA, nonpancreatic secretory PLA2 (sPLA2). In a chromogenic isolated enzyme assay, LY315920 inhibited sPLA2 activity with an IC50 of 9 +/- 1 nM or 7.3 x 10(-6) mole fraction, which
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::27d9bc449c4efee413baa94c5962200b
https://pubmed.ncbi.nlm.nih.gov/10027849
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2
Phosphorylation and activation of Ca(2+)-sensitive cytosolic phospholipase A2 in MCII mast cells mediated by high-affinity Fc receptor for IgE
Autor: N W Roehm, R M Kramer, S M Spaethe, Susan Currie, E F Roberts
Publikováno v: University of Strathclyde
In the present study we examined the activation of Ca(2+)-sensitive cytosolic phospholipase A2 (cPLA2) after aggregation of cell-surface high-affinity Fc receptors for IgE (Fc epsilon RI) on mast cells. MCII mast cells (a factor-dependent bone-marrow
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ded226839a6fc91fd64350a13fff46f5
https://europepmc.org/articles/PMC1137421/
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3
Cyclosporine and FK506 inhibition of murine mast cell cytokine production
Autor: S M, Hatfield, N W, Roehm
Publikováno v: The Journal of pharmacology and experimental therapeutics. 260(2)
The ability of cyclosporine (CSA) and FK506 to inhibit cytokine production by factor-dependent murine mast cell lines was investigated. The mast cell clone, MC/9, and two mast cell lines, MCIII and MCVI, were stimulated to produce cytokines with phor
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c2c92a8d5a34efb8f24aaa72a9626bba
https://pubmed.ncbi.nlm.nih.gov/1371158
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4
Patterns of lymphokine production by primary antigen-specific/MHC restricted murine helper T cell clones
Autor: N W Roehm, G H Rodgers, P Marder, S M Hatfield
Publikováno v: Immunological investigations. 20(1)
In this study we examined a panel of CD4+ antigen specific/MHC restricted T cell clones for their ability to secrete IL-2, IL-4, and IFN-gamma upon stimulation with con A, three lymphokines which are diagnostic for the TH1 and TH2 subtypes of helper
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f7be90baf1f1a55d4133c339b1a22e5
https://pubmed.ncbi.nlm.nih.gov/1711510
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6
The major histocompatibility complex-restricted antigen receptor on T cells: the genetics of expression of an allotype
Autor: N W Roehm, A Carbone, E Kushnir, B A Taylor, R J Riblet, P Marrack, J W Kappler
Publikováno v: The Journal of Immunology. 135:2176-2182
The monoclonal antibody KJ16-133 binds an allelic determinant expressed on the antigen-specific, major histocompatibility complex (MHC)-restricted receptors on approximately 20% of T cells in most mouse strains. The locus controlling the presence or
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::87dbc6603fe36a3317ce0e08c02c43bd
https://doi.org/10.4049/jimmunol.135.3.2176
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