Výsledky vyhledávání - "N V, Sumbatian"

[Amino acid and peptide derivatives of the tylosin family of macrolide antibiotics modified at the aldehyde group]

Autor: N V, Sumbatian, I V, Kuznetsova, V V, Karpenko, N V, Fedorova, V A, Chertkov, G A, Korshunova, A A, Bogdanov

Publikováno v: Bioorganicheskaia khimiia. 36(2)

Fourteen new functionally active amino acid and peptide derivatives of the antibiotics tylosin, desmycosin, and 5-O-mycaminosyltylonolide were synthesized in order to study the interaction of the growing polypeptide chain with the ribosomal tunnel. T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::00bbecb866e9b02d08e01bc50848614d
https://pubmed.ncbi.nlm.nih.gov/20531486

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[Synthesis of cyclic analogues of the nerve growth factor loop 4]

Autor: A A, Morozova, N V, Sumbatian, V P, Lezina, V Kh, Akparov, G A, Korshunova, T A, Gudasheva

Publikováno v: Bioorganicheskaia khimiia. 34(5)

Cyclic peptides cyclo(-Gly-Asp-Glu-Lys-), cyclo(-Gly-Gly-Asp-Glu-Lys-) and cyclo(-Gly-Gly-Gly-Asp-Glu-Lys-) were synthesized as models of the beta-turn of nerve growth factor loop 4. The corresponding protected linear precursors were obtained in 52-8

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1e5c58331f296e340a1b94a526850922
https://pubmed.ncbi.nlm.nih.gov/19060936

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[New photoreactive cleavable reagents with (trifluoromethyl)diazirine group]

Autor: M T, Mchedlidze, N V, Sumbatian, D A, Bondar', M V, Taranenko, G A, Korshunova

Publikováno v: Bioorganicheskaia khimiia. 29(2)

Photoreactive cross-linking reagents that simultaneously contain a trifluoromethyldiazirine and an o-nitrobenzyl groups were synthesized for the first time. Photochemical properties of the reagents were studied, and the possibility of separate activa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c791e6d925e60c9a24e1e4f106e407cb
https://pubmed.ncbi.nlm.nih.gov/12708321

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[Photoactivated reagents based on aryl(trifluoromethyl)diazirines: synthesis and use for studying nucleic acid-protein interactions]

Autor: G A, Korshunova, N V, Sumbatian, A N, Topin, M T, Mchedlidze

Publikováno v: Molekuliarnaia biologiia. 34(6)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7c7bcb86e01aab7ebe3021b771b36240
https://pubmed.ncbi.nlm.nih.gov/11186014

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[Detection of nucleic amino acid enantiomers by HPLC with preliminary modification by o-phthalic aldehyde]

Autor: O I, Gurentsova, M V, Savchenko, N V, Sumbatian, G A, Korshunova, V K, Shviadas

Publikováno v: Bioorganicheskaia khimiia. 23(11)

The use of reversed-phase HPLC with UV detection at 254 nm for the separation of stereoisomers of nucleoamino acids, namely, pyrimidyl and purinyl derivatives of alanine, after premodification with o-phthalic aldehyde and N-acetyl-L-cysteine was stud

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4169e1768f553c8622973b7acfabe2fb
https://pubmed.ncbi.nlm.nih.gov/9518427

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[Lipophilic derivatives of caffeic acid as lipoxygenase inhibitors with antioxidant properties]

Autor: O K, Mirzoeva, G F, Sud'ina, M A, Pushkareva, G A, Korshunova, N V, Sumbatian, S D, Varfolomeev

Publikováno v: Bioorganicheskaia khimiia. 21(2)

We have prepared two lipophilic derivatives of caffeic acid at the carboxylic function--caffeic acid phenethyl ester, an active component of propolis, and N,N'-dicyclohexyl-O-(3,4-dihydroxycinnamoyl)-isourea. Both substances inhibit barley 5-lipoxyge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::350a2085baec89a8d5a7da83f9a9f1a1
https://pubmed.ncbi.nlm.nih.gov/7538294

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[Dermorphin: synthesis of analogs and structuro-functional relations]

Autor: G A, Korshunova, N V, Sumbatian

Publikováno v: Bioorganicheskaia khimiia. 15(7)

The review analyzes structure-activity relations among dermorphin analogues. Dermorphin (Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH2) is one of natural opioid peptides having a unique structure and exerting a very potent and prolonged antinociceptive effect. M

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cc34bdb484ab1a6ee80766f77521d0ef
https://pubmed.ncbi.nlm.nih.gov/2684167

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[Conformation-activity relations of dermorphin and its pentapeptide analogs]

Autor: M D, Shenderovich, I T, Liepinia, G V, Nikiforovich, N V, Sumbatian, G A, Korshunova, Iu P, Shvachkin

Publikováno v: Bioorganicheskaia khimiia. 15(9)

Low-energy peptide backbone structures of dermorphin (DM), amide of its N-terminal pentapeptide (DM 1-5) and DM 1-5 analogues with substitutions of Gly4 for Leu, D-Gln, Aal or Tal were determined by energy calculations. The above analogues were shown

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::139296725da8e1b0e57a5e3d481eb152
https://pubmed.ncbi.nlm.nih.gov/2556149

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[Comparison of the opioid activity of a number of enkephalin and dermorphin analogs]

Autor: O N, Chichenkov, N V, Sumbatian, O N, Riabtseva, G A, Korshunova, V A, Shorr

Publikováno v: Farmakologiia i toksikologiia. 51(5)

In search of selective ligands of opioid receptors there was synthetized a number of shortened dermorphin analogues containing nucleic amino acid substituents in positions 4 and 5 and also nucleic amino acid analogues of enkephalins. All synthetized

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5ccb3897246dffc5b1067132d7f14ed6
https://pubmed.ncbi.nlm.nih.gov/2850219

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