Zobrazeno 1 - 10
of 74
pro vyhledávání: '"N V, Rajeshkumar"'
Autor:
Asma Begum, Theodore Ewachiw, Clinton Jung, Ally Huang, K Jessica Norberg, Luigi Marchionni, Ross McMillan, Vesselin Penchev, N V Rajeshkumar, Anirban Maitra, Laura Wood, Chenguang Wang, Christopher Wolfgang, Ana DeJesus-Acosta, Daniel Laheru, Irina M Shapiro, Mahesh Padval, Jonathan A Pachter, David T Weaver, Zeshaan A Rasheed, William Matsui
Publikováno v:
PLoS ONE, Vol 12, Iss 7, p e0180181 (2017)
Cancer stem cells (CSCs) play an important role in the clonogenic growth and metastasis of pancreatic ductal adenocarcinoma (PDAC). A hallmark of PDAC is the desmoplastic reaction, but the impact of the tumor microenvironment (TME) on CSCs is unknown
Externí odkaz:
https://doaj.org/article/0b74a9ba79204b4f9aae1b5cbd528850
Autor:
Tony E. Dorado, Pablo de León, Asma Begum, Hester Liu, Daming Chen, N. V. Rajeshkumar, Romain Rey-Rodriguez, Coralie Hoareau-Aveilla, Chantal Alcouffe, Marikki Laiho, James C. Barrow
Publikováno v:
ACS Med Chem Lett
[Image: see text] RNA polymerase I (Pol I) transcribes ribosomal DNA (rDNA) into the 47S ribosomal RNA (rRNA) precursor. Further processing produces the 28S, 5.8S, and 18S rRNAs that are assembled into mature ribosomes. Many cancers exhibit higher Po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fa34c25f3a8a65077683278c09bccd6
https://europepmc.org/articles/PMC9014438/
https://europepmc.org/articles/PMC9014438/
Autor:
Peter J. O'Dwyer, Zeshaan A. Rasheed, Ramesh K. Ramanathan, Florencia McAllister, Daniel D. Von Hoff, Daniel A. Laheru, Anirban Maitra, Lei Zheng, Robert A. Anders, Ana De Jesus-Acosta, Asma Begum, N. V. Rajeshkumar, Shinichi Yabuuchi, Roeland F. de Wilde, Bhavina D O Batukbhai, Ismet Sahin, Elizabeth A. Sugar
Publikováno v:
British Journal of Cancer
Background The Hedgehog (Hh) signalling pathway is overexpressed in pancreatic ductal adenocarcinoma (PDA). Preclinical studies have shown that Hh inhibitors reduce pancreatic cancer stem cells (pCSC), stroma and Hh signalling. Methods Patients with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccb17a84c350d9380db50e7e65d74956
https://doi.org/10.1038/s41416-019-0683-3
https://doi.org/10.1038/s41416-019-0683-3
Autor:
N. V. Rajeshkumar, Martin Handfield, Johan A. Kers, Jae H. Park, Scott Moncrief, Anthony W. Defusco
Publikováno v:
Toxicology and Applied Pharmacology. 374:32-40
Clostridium difficile associated disease (CDAD) is the leading infectious cause of antibiotic-associated diarrhea and colitis in the United States. Both the incidence and severity of CDAD have been increased over the past two decades. We evaluated th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::825121e38ff74f4e56cf7418d7254f12
https://doi.org/10.1016/j.taap.2019.04.019
https://doi.org/10.1016/j.taap.2019.04.019
Autor:
Rachel M. Sherman, Wenjun Fan, Hester Liu, Stephanie Pitts, N. V. Rajeshkumar, Brittany Ford, Marikki Laiho, Eetu Eklund
Polymorphism drives survival under stress and provides adaptability. Genetic polymorphism of ribosomal RNA (rRNA) genes derives from internal repeat variation of this multicopy gene, and from interindividual variation. A considerable amount of rRNA s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::83ebc8769a77cc6b1bbd6cbf86ed46c5
https://doi.org/10.1101/2021.07.21.453267
https://doi.org/10.1101/2021.07.21.453267
Guided by the principle of primum non nocere (first do no harm), we report a cautionary note on the potential fatal toxicity of chloroquine (CQ) or hydroxychloroquine (HCQ) in combination with anti-diabetic drug metformin. We observed that the combin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbe6a5e31f2e210d5ade0770d4543057
Autor:
Jason E. Toombs, Rolf A. Brekken, Noah Sorrelle, Anirban Maitra, James B. Lorens, N. V. Rajeshkumar, Victoria H. Cruz, Katarzyna Wnuk-Lipinska, Mary Topalovski, Kathleen Ludwig, Shinichi Yabuuchi, Wenting Du
Publikováno v:
Cancer Research. 78:246-255
Activation of the receptor tyrosine kinase Axl is associated with poor outcomes in pancreatic cancer (PDAC), where it coordinately mediates immune evasion and drug resistance. Here, we demonstrate that the selective Axl kinase inhibitor BGB324 target
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa612eadcd77e490451311cb88b53434
https://doi.org/10.1158/0008-5472.can-17-1973
https://doi.org/10.1158/0008-5472.can-17-1973
Autor:
Shihe Hou, Shinichi Yabuuchi, Zeen Tong, Carla Heise, Daniel D. Von Hoff, Manuel Hidalgo, N. V. Rajeshkumar, Shweta G. Pai, Daniel W. Pierce, Anirban Maitra, Scott Bateman
Publikováno v:
British Journal of Cancer
Background: Albumin-bound paclitaxel (nab-paclitaxel, nab-PTX) plus gemcitabine (GEM) combination has demonstrated efficient antitumour activity and statistically significant overall survival of patients with metastatic pancreatic ductal adenocarcino
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71068e0e93b5a2d7cdfc6b348d6dacaf
https://doi.org/10.1038/bjc.2016.215
https://doi.org/10.1038/bjc.2016.215
Autor:
Prasanta Dutta, Joshua D. Rabinowitz, N. V. Rajeshkumar, Shinichi Yabuuchi, Roeland F. de Wilde, Manuel Hidalgo, Jurre J. Kamphorst, Chi V. Dang, Anirban Maitra, Sanjay K. Jain, Gary V. Martinez, Robert J. Gillies, Anne Le
Publikováno v:
Cancer Research. 75:3355-3364
The “Warburg effect” describes a peculiar metabolic feature of many solid tumors, namely their increased glucose uptake and high glycolytic rates, which allow cancer cells to accumulate building blocks for the biosynthesis of macromolecules. Duri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e6fc984c582577f10c67b1c9a7bc346
https://doi.org/10.1158/0008-5472.can-15-0108
https://doi.org/10.1158/0008-5472.can-15-0108
Autor:
N. V. Rajeshkumar, Melissa L. Fishel, Mircea Ivan, Yanlin Jiang, Zhangsheng Yu, Meihua Luo, Cecilia Devlin, Kelsey P. Lipking, Derek P. Logsdon, Xue Wu, Ying He, Glenda Scandura, Mark R. Kelley, Anirban Maitra, Yan Tong
Publikováno v:
Journal of Biological Chemistry. 290:3057-3068
Apurinic/apyrimidinic endonuclease/redox factor-1 (APE1/Ref-1) (henceforth referred to as Ref-1) is a multifunctional protein that in addition to its base excision DNA repair activity exerts redox control of multiple transcription factors, including
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93841063edce952f77ead451560239ee
https://doi.org/10.1074/jbc.m114.621995
https://doi.org/10.1074/jbc.m114.621995