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Immunogenicity of recombinant IL-2 modified by covalent attachment of polyethylene glycol

Autor: N V Katre

Publikováno v: The Journal of Immunology. 144:209-213

Human rIL-2, expressed and purified from Escherichia coli, is currently being tested as an anticancer therapeutic agent. Some of the patients undergoing clinical trials with rIL-2 have developed antibodies to rIL-2. We describe a chemical modificatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6774eff31aa4e69d85fd7368ee4f7a78
https://doi.org/10.4049/jimmunol.144.1.209

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Immunogenicity of recombinant IL-2 modified by covalent attachment of polyethylene glycol

Autor: N V, Katre

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 144(1)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7eb063568e12c39cacd734d39b83725e
https://pubmed.ncbi.nlm.nih.gov/2295792

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Relationship of effective molecular size to systemic clearance in rats of recombinant interleukin-2 chemically modified with water-soluble polymers

Autor: J. D. Young, Zhen-Ping Luo, N. V. Katre, M. J. Knauf, P. Hirtzer, D. P. Bell

Publikováno v: Journal of Biological Chemistry. 263:15064-15070

We have examined the effects of a variety of chemical modifications to recombinant human interleukin-2 (rIL-2) on its pharmacokinetic behavior in rats. Unmodified rIL-2 is cleared from plasma with half-lives of 3 and 44 min for the alpha and beta pha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3feaaa86bcdfd9d4936dfbd76c5fa08d
https://doi.org/10.1016/s0021-9258(18)68146-3

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Relationship of effective molecular size to systemic clearance in rats of recombinant interleukin-2 chemically modified with water-soluble polymers

Autor: M J, Knauf, D P, Bell, P, Hirtzer, Z P, Luo, J D, Young, N V, Katre

Publikováno v: The Journal of biological chemistry. 263(29)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b7f4f8c945b8d852de085a2fd8624cf6
https://pubmed.ncbi.nlm.nih.gov/3049599

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Schedule dependency of the antitumor activity and toxicity of polyethylene glycol-modified interleukin 2 in murine tumor models

Autor: R J, Zimmerman, S L, Aukerman, N V, Katre, J L, Winkelhake, J D, Young

Publikováno v: Cancer research. 49(23)

Modification of recombinant human interleukin 2 (rhIL-2) with monomethoxy polyethylene glycol has been shown to alter its pharmacokinetic properties. Therefore, we investigated the pharmacological parameters of schedule and dose in order to assess th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1583caf5c611aa4349e48490e7241aa3
https://pubmed.ncbi.nlm.nih.gov/2819708

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Development of a lyophilized formulation of interleukin-2

Autor: M S, Hora, R K, Rana, C L, Wilcox, N V, Katre, P, Hirtzer, S N, Wolfe, J W, Thomson

Publikováno v: Europe PubMed Central

Native human interleukin-2 (IL-2) comprises a group of glycoproteins of MW 13,000-17,500. Recombinant human IL-2 (rhIL-2) (Cetus) is derived from E. coli and is not glycosylated. We have evaluated several processes for manufacturing rhIL-2, based on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::a9e3fd7d3c10e4630824b6c051329f96
http://europepmc.org/abstract/med/1592178

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