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Autor:
C-O Leong, Heng Lungh Choo, Shew Fung Wong, L-W Hii, K H Tiong, Felicia Fei-Lei Chung, N Tw Khor, Boon Shing Tan, Rozita Rosli, I Ks Yap, S-K Cheong, Si Hoey Tan, S Pani
Publikováno v:
Cell Death & Disease
p53 is the most frequently mutated tumor-suppressor gene in human cancers. Unlike other tumor-suppressor genes, p53 mutations mainly occur as missense mutations within the DNA-binding domain, leading to the expression of full-length mutant p53 protei