Zobrazeno 1 - 10
of 164
pro vyhledávání: '"N Tony Eissa"'
Autor:
Afshin Ebrahimpour, Manisha Ahir, Min Wang, Anil G. Jegga, Mark D. Bonnen, N. Tony Eissa, Sydney B. Montesi, Ganesh Raghu, Yohannes T. Ghebre
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal lung disease of unknown etiology. Currently, pirfenidone and nintedanib are the only FDA-approved drugs for the treatment of IPF and are now the standard of care. This is a signi
Externí odkaz:
https://doaj.org/article/3ce6a0a83e064759a2ff579276fe6229
Autor:
Afshin Ebrahimpour, Min Wang, Li Li, Anil G. Jegga, Mark D. Bonnen, N. Tony Eissa, Ganesh Raghu, Soma Jyothula, Farrah Kheradmand, Nicola A. Hanania, Ivan O. Rosas, Yohannes T. Ghebre
Publikováno v:
Journal of Inflammation, Vol 18, Iss 1, Pp 1-14 (2021)
Abstract Introduction Idiopathic pulmonary fibrosis (IPF) is an orphan disease characterized by progressive loss of lung function resulting in shortness of breath and often death within 3–4 years of diagnosis. Repetitive lung injury in susceptible
Externí odkaz:
https://doaj.org/article/e4e7d799ccab4aaabac4af93292863d5
Lymphangioleiomyomatosis (LAM) is a progressive cystic lung disease affecting some women with tuberous sclerosis complex (TSC). Sporadic LAM can develop in women without TSC, owing to somatic mutations in the TSC2 gene. Accumulating evidence supports
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::79e3aaf6c65a33a62672cd145398bddb
https://doi.org/10.1158/0008-5472.c.6505995
https://doi.org/10.1158/0008-5472.c.6505995
Increased phospho-Src in LAM lungs (Figure S1); Enhanced activation of Src, STAT3 and Snail in human LAM cells (Figure S2); mTOR activation in TSC2-deficient cells (Figure S3); Src kinase is activated in TSC2-deficient cells (Figure S4); Knockdown of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab71a542f2b66916c1421fb834270448
https://doi.org/10.1158/0008-5472.22402134.v1
https://doi.org/10.1158/0008-5472.22402134.v1
Autor:
Abhisek Bhattacharya, Qin Wei, Jin Na Shin, Elmoataz Abdel Fattah, Diana L. Bonilla, Qian Xiang, N. Tony Eissa
Publikováno v:
Cell Reports, Vol 12, Iss 11, Pp 1731-1739 (2015)
Autophagy, an intracellular degradation and energy recycling mechanism, is emerging as an important regulator of immune responses. However, the role of autophagy in regulating neutrophil functions is not known. We investigated neutrophil biology usin
Externí odkaz:
https://doaj.org/article/59c3ed9d92ff431aaeffa0e32cc0a222
Publikováno v:
Molecular & Cellular Oncology, Vol 4, Iss 6 (2017)
TFEB is a master regulator for transcription of genes involved in autophagy, lysosome and mitochondrial biogenesis. Activity of TFEB is inhibited upon its phosphorylation. STUB1, a chaperone-dependent E3 ubiquitin ligase, modulates TFEB activity by p
Externí odkaz:
https://doaj.org/article/f018ee2c94df495c8d2cfd050a9adbdc
Publikováno v:
The Journal of Immunology. 207:661-670
Inflammation contributes to the pathogenesis and morbidity of wide spectrum of human diseases. The inflammatory response must be actively controlled to prevent bystander damage to tissues. Yet, the mechanisms controlling excessive inflammatory respon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0808c04c346bd5ca13bc724ca274f6de
https://doi.org/10.4049/jimmunol.2000416
https://doi.org/10.4049/jimmunol.2000416
Autor:
Jin Wang, Subramanian Dhandayuthapani, Dekai Zhang, Chandrashekhar Pasare, Kishore Das, Chinnaswamy Jagannath, Jianjun Sun, Arshad Khan, Robert L. Hunter, Jaymie L. Estrella, Emily Soudani, Sankaralingam Saikolappan, Pearl Bakhru, Christopher R. Singh, N. Tony Eissa, Yue Ma
Publikováno v:
npj Vaccines, Vol 4, Iss 1, Pp 1-19 (2019)
NPJ Vaccines
NPJ Vaccines
Mycobacterium bovis BCG is widely used as a vaccine against tuberculosis due to M. tuberculosis (Mtb), which kills millions of people each year. BCG variably protects children, but not adults against tuberculosis. BCG evades phagosome maturation, aut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f5fd43a56e2e43f9e3c366b2d4ef373
http://link.springer.com/article/10.1038/s41541-019-0122-8
http://link.springer.com/article/10.1038/s41541-019-0122-8
Autor:
Lang Rao, N. Tony Eissa
Publikováno v:
Journal of Innate Immunity. 12:21-30
Autophagy is a major intracellular digestion system that delivers cytoplasmic components for degradation and recycling. In this capacity, autophagy plays an important role in maintaining cellular homeostasis by mediating the degradation of cellular m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adb3152d1e2a44818502eca164dcbe49
https://doi.org/10.1159/000497414
https://doi.org/10.1159/000497414
Autor:
Min Wang, Yohannes T. Ghebre, Li Li, Mark D. Bonnen, Anil G. Jegga, Afshin Ebrahimpour, Farrah Kheradmand, S. Jyothula, Nicola A. Hanania, N. Tony Eissa, Ganesh Raghu, Ivan O. Rosas
Publikováno v:
Journal of Inflammation (London, England)
Journal of Inflammation, Vol 18, Iss 1, Pp 1-14 (2021)
Journal of Inflammation, Vol 18, Iss 1, Pp 1-14 (2021)
Introduction Idiopathic pulmonary fibrosis (IPF) is an orphan disease characterized by progressive loss of lung function resulting in shortness of breath and often death within 3–4 years of diagnosis. Repetitive lung injury in susceptible individua
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57fef4e49d39959e5124d380e78d6d1d
http://europepmc.org/articles/PMC8136131
http://europepmc.org/articles/PMC8136131