Zobrazeno 1 - 10
of 210
pro vyhledávání: '"N Thai An"'
Autor:
Lili Salinas, Claire B. Montgomery, Francisco Figueroa, Phung N. Thai, Nipavan Chiamvimonvat, Gino Cortopassi, Elena N. Dedkova
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-15 (2024)
Abstract Friedreich’s ataxia (FA) is an autosomal recessive disorder caused by reduced frataxin (FXN) expression in mitochondria, where the lethal component is cardiomyopathy. Using the conditional Fxn flox/null::MCK-Cre knock-out (Fxn-cKO) mouse m
Externí odkaz:
https://doaj.org/article/307e6813025546cdb878edf29300a76e
Autor:
Maartje Westhoff, Silvia G. del Villar, Taylor L. Voelker, Phung N. Thai, Heather C. Spooner, Alexandre D. Costa, Padmini Sirish, Nipavan Chiamvimonvat, Eamonn J. Dickson, Rose E. Dixon
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Cardiac dysfunction is a hallmark of aging in humans and mice. Here we report that a two-week treatment to restore youthful Bridging Integrator 1 (BIN1) levels in the hearts of 24-month-old mice rejuvenates cardiac function and substantially
Externí odkaz:
https://doaj.org/article/b0477fcf8cac487d9b9bce149837c365
Autor:
Jeong Han Lee, Maria C. Perez-Flores, Seojin Park, Hyo Jeong Kim, Yingying Chen, Mincheol Kang, Jennifer Kersigo, Jinsil Choi, Phung N. Thai, Ryan L. Woltz, Dolores Columba Perez-Flores, Guy Perkins, Choong-Ryoul Sihn, Pauline Trinh, Xiao-Dong Zhang, Padmini Sirish, Yao Dong, Wayne Wei Feng, Isaac N. Pessah, Rose E. Dixon, Bernd Sokolowski, Bernd Fritzsch, Nipavan Chiamvimonvat, Ebenezer N. Yamoah
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract The inner ear is the hub where hair cells (HCs) transduce sound, gravity, and head acceleration stimuli to the brain. Hearing and balance rely on mechanosensation, the fastest sensory signals transmitted to the brain. The mechanoelectrical t
Externí odkaz:
https://doaj.org/article/2460730132124905aa50c50a2faffa24
Autor:
Maartje Westhoff, Silvia G. del Villar, Taylor L. Voelker, Phung N. Thai, Heather C. Spooner, Alexandre D. Costa, Padmini Sirish, Nipavan Chiamvimonvat, Eamonn J. Dickson, Rose E. Dixon
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/c1be2283042645839fbc07427ec467c0
Autor:
Yao-Hui Sun, Hillary K.J. Kao, Phung N. Thai, Regan Smithers, Che-Wei Chang, Dalyir Pretto, Sergey Yechikov, Sarah Oppenheimer, Amanda Bedolla, Brooke A. Chalker, Rana Ghobashy, Jan A. Nolta, James W. Chan, Nipavan Chiamvimonvat, Deborah K. Lieu
Publikováno v:
Cell Reports, Vol 42, Iss 12, Pp 113505- (2023)
Summary: The composite material-like extracellular matrix (ECM) in the sinoatrial node (SAN) supports the native pacemaking cardiomyocytes (PCMs). To test the roles of SAN ECM in the PCM phenotype and function, we engineered reconstructed-SAN heart t
Externí odkaz:
https://doaj.org/article/354257b1ee964620a53ac8fc64610b05
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 10 (2023)
Externí odkaz:
https://doaj.org/article/61d417db32e94f798b147e7eb8d3107d
Autor:
Lu Ren, Phung N. Thai, Raghavender Reddy Gopireddy, Valeriy Timofeyev, Hannah A. Ledford, Ryan L. Woltz, Seojin Park, Jose L. Puglisi, Claudia M. Moreno, Luis Fernando Santana, Alana C. Conti, Michael I. Kotlikoff, Yang Kevin Xiang, Vladimir Yarov-Yarovoy, Manuela Zaccolo, Xiao-Dong Zhang, Ebenezer N. Yamoah, Manuel F. Navedo, Nipavan Chiamvimonvat
Publikováno v:
JCI Insight, Vol 7, Iss 22 (2022)
Sinoatrial node (SAN) cells are the heart’s primary pacemaker. Their activity is tightly regulated by β-adrenergic receptor (β-AR) signaling. Adenylyl cyclase (AC) is a key enzyme in the β-AR pathway that catalyzes the production of cAMP. There
Externí odkaz:
https://doaj.org/article/a77e387d0aea4cd39fe56437febaaf3a
Autor:
Yankun Lyu, Valeriy Timofeyev, James Overton, Phung N. Thai, Ebenezer N. Yamoah, Nipavan Chiamvimonvat, Xiao-Dong Zhang
Publikováno v:
STAR Protocols, Vol 3, Iss 2, Pp 101301- (2022)
Summary: Intracellular pH (pHi) plays critical roles in the regulation of cardiac function. Methods and techniques for cardiac pHi measurement have continued to evolve since early 1960s. Fluorescent microscopy is the most recently developed technique
Externí odkaz:
https://doaj.org/article/bb83ef9cd538486eb3c234d3e5218493
Publikováno v:
Frontiers in Physiology, Vol 12 (2022)
Atrial fibrillation (AF) remains the most common arrhythmia seen clinically. The incidence of AF is increasing due to the aging population. AF is associated with a significant increase in morbidity and mortality, yet current treatment paradigms have
Externí odkaz:
https://doaj.org/article/197eaa5838744492a732007ea068d3b4
Autor:
Yankun Lyu, Phung N. Thai, Lu Ren, Valeriy Timofeyev, Zhong Jian, Seojin Park, Kenneth S. Ginsburg, James Overton, Julie Bossuyt, Donald M. Bers, Ebenezer N. Yamoah, Ye Chen-Izu, Nipavan Chiamvimonvat, Xiao-Dong Zhang
Publikováno v:
iScience, Vol 25, Iss 1, Pp 103624- (2022)
Summary: The mammalian heart beats incessantly with rhythmic mechanical activities generating acids that need to be buffered to maintain a stable intracellular pH (pHi) for normal cardiac function. Even though spatial pHi non-uniformity in cardiomyoc
Externí odkaz:
https://doaj.org/article/71ec355c18ca46c0abb871b3e9983834