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Autor:
F, Arguello, M, Alexander, J A, Sterry, G, Tudor, E M, Smith, N T, Kalavar, J F, Greene, W, Koss, C D, Morgan, S F, Stinson, T J, Siford, W G, Alvord, R L, Klabansky, E A, Sausville
Publikováno v:
Blood. 91(7)
Flavopiridol is a novel semisynthetic flavone derivative of the alkaloid rohitukine. Flavopiridol is known to inhibit potently the activity of multiple cyclin-dependent kinases. We have assessed its effects on normal and malignant cells in preclinica