Zobrazeno 1 - 10
of 1 167
pro vyhledávání: '"N Sternberg"'
Autor:
Irfan Cicin, Elizabeth R. Plimack, Howard Gurney, Raya Leibowitz, Boris Y. Alekseev, Francis X. Parnis, Avivit Peer, Andrea Necchi, Joaquim Bellmunt, Hiroyuki Nishiyama, Jason Clark, Mihaela Munteanu, Ritesh Kataria, Calvin Jia, Thomas Powles, Cora N. Sternberg
Publikováno v:
BMC Cancer, Vol 23, Iss S1, Pp 1-11 (2024)
Abstract Background Indoleamine 2,3-dioxygenase 1 (IDO1) levels correlate with poor outcomes in urothelial carcinoma (UC). IDO1 and programmed death-ligand 1 (PD-L1) are often co-expressed. Epacadostat is a potent and highly selective inhibitor of ID
Externí odkaz:
https://doaj.org/article/263d9199baf8485699909ce6591e41d9
Autor:
Motohide Uemura, Hiroaki Kikukawa, Yasuhiro Hashimoto, Hiroji Uemura, Atsushi Mizokami, Masashi Kato, Hisashi Matsushima, Takeo Kosaka, Motonobu Nakamura, Satoshi Fukasawa, Matthew R. Smith, Bertrand Tombal, Maha Hussain, Fred Saad, Karim Fizazi, Cora N. Sternberg, E. David Crawford, Haruka Kakiuchi, Masanao Akiyama, Rui Li, Iris Kuss, Heikki Joensuu, Hiroyoshi Suzuki
Publikováno v:
Cancer Medicine, Vol 13, Iss 21, Pp n/a-n/a (2024)
Abstract Background In the global ARASENS study (NCT02799602), darolutamide plus androgen‐deprivation therapy (ADT) and docetaxel significantly reduced risk of death by 32.5% versus placebo plus ADT and docetaxel (hazard ratio [HR] 0.68; 95% confid
Externí odkaz:
https://doaj.org/article/1058407c6e5d4f8494ab24581515bb95
Autor:
Ariel E. Marciscano, Sydney Wolfe, Xi Kathy Zhou, Christopher E. Barbieri, Silvia C. Formenti, Jim C. Hu, Ana M. Molina, David M. Nanus, Jones T. Nauseef, Douglas S. Scherr, Cora N. Sternberg, Scott T. Tagawa, Himanshu Nagar
Publikováno v:
BMC Cancer, Vol 23, Iss 1, Pp 1-9 (2023)
Abstract Background Ultra-hypofractionated image-guided stereotactic body radiotherapy (SBRT) is increasingly used for definitive treatment of localized prostate cancer. Magnetic resonance imaging-guided radiotherapy (MRgRT) facilitates improved visu
Externí odkaz:
https://doaj.org/article/fa243c6550cd4849bd0e24f9ff480799
Autor:
Majd Al Assaad, Nara Shin, Michael Sigouros, Jyothi Manohar, Zoia Antysheva, Nikita Kotlov, Daria Kiriy, Anastasiia Nikitina, Mikhail Kleimenov, Anastasiya Tsareva, Anastasiya Makarova, Victoria Fomchenkova, Julia Dubinina, Alexandra Boyko, Nava Almog, David Wilkes, Joanna G. Escalon, Ashish Saxena, Olivier Elemento, Cora N. Sternberg, David M. Nanus, Juan Miguel Mosquera
Publikováno v:
Frontiers in Oncology, Vol 13 (2024)
Cancer of unknown primary (CUP) represents a significant diagnostic and therapeutic challenge, being the third to fourth leading cause of cancer death, despite advances in diagnostic tools. This article presents a successful approach using a novel ge
Externí odkaz:
https://doaj.org/article/13acdf4ab307414bb760f79ae7f83824
Autor:
Celestia S. Higano, Daniel J. George, Neal D. Shore, Oliver Sartor, Kurt Miller, Peter S. Conti, Cora N. Sternberg, Fred Saad, Juan Pablo Sade, Joaquim Bellmunt, Matthew R. Smith, Kumari Chandrawansa, Per Sandström, Frank Verholen, Bertrand Tombal
Publikováno v:
EClinicalMedicine, Vol 60, Iss , Pp 101993- (2023)
Summary: Background: Radium-223, a targeted alpha therapy, is approved to treat bone-dominant metastatic castration-resistant prostate cancer (mCRPC), based on significantly prolonged overall survival versus placebo and a favourable safety profile in
Externí odkaz:
https://doaj.org/article/ede8b4395fd74aa190c82bdfe489b529
Autor:
Johannes C. van derMijn, Kenneth W. Eng, Pooja Chandra, Evan Fernandez, Sinan Ramazanoglu, Alexandros Sigaras, Clara Oromendia, Lorraine J. Gudas, Scott T. Tagawa, David M. Nanus, Bishoy F. Faltas, Himisha Beltran, Cora N. Sternberg, Olivier Elemento, Andrea Sboner, Juan Miguel Mosquera, Ana M. Molina
Publikováno v:
Molecular Oncology, Vol 16, Iss 12, Pp 2384-2395 (2022)
Primary clear cell renal cell carcinoma (ccRCC) has been previously characterized, but the genomic landscape of metastatic ccRCC is largely unexplored. Here, we performed whole exome sequencing (WES) in 68 samples from 44 patients with ccRCC, includi
Externí odkaz:
https://doaj.org/article/c682ec50c37c498fac15bed303bb33ff
Autor:
Michiel S. van der Heijden, Thomas Powles, Daniel Petrylak, Ronald de Wit, Andrea Necchi, Cora N. Sternberg, Nobuaki Matsubara, Hiroyuki Nishiyama, Daniel Castellano, Syed A. Hussain, Aristotelis Bamias, Georgios Gakis, Jae-Lyun Lee, Scott T. Tagawa, Ulka Vaishampayan, Jeanny B. Aragon-Ching, Bernie J. Eigl, Rebecca R. Hozak, Erik R. Rasmussen, Meng Summer Xia, Ryan Rhodes, Sameera Wijayawardana, Katherine M. Bell-McGuinn, Amit Aggarwal, Alexandra Drakaki
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Identification of biomarkers to stratify patients who might benefit from treatment is needed to optimize targeted therapies. Here, based on an analysis of the RANGE trial (NCT02426125), the authors report potentially predictive biomarkers for surviva
Externí odkaz:
https://doaj.org/article/48cfab2e04994935a36166abe99febbf
Autor:
Ernest Choy, Yohann Loriot, Fabio Calabrò, Cora N Sternberg, Guillermo De Velasco, Daniel Castellano, Roubini Zakopoulou, Aristotelis Bamias, Nicholas James, Axel Merseburger, F Lopez-Rios, Mario Kramer, Kimon Tzannis
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 1 (2023)
Background Bellmunt Risk Score, based on Eastern Cooperative Oncology Group (ECOG) performance status (PS), hemoglobin levels and presence of liver metastases, is the most established prognostic algorithm for patients with advanced urothelial cancer
Externí odkaz:
https://doaj.org/article/a82e3f41ebdc4c3989d1f4211495a2b2
Autor:
Cora N. Sternberg, Nara Shin, Konstantin Chernyshov, Fabio Calabro, Linda Cerbone, Giuseppe Procopio, Natalia Miheecheva, Georgy Sagaradze, Alisa Zaichikova, Naira Samarina, Alexandra Boyko, Jessica H. Brown, Leysan Yunusova, Daniela Guevara, Jyothi Manohar, Michael Sigouros, Majd Al Assaad, Olivier Elemento, Juan Miguel Mosquera
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Although immune checkpoint inhibitors (ICIs) are increasingly used as second-line treatments for urothelial cancer (UC), only a small proportion of patients respond. Therefore, understanding the mechanisms of response to ICIs is critical to improve c
Externí odkaz:
https://doaj.org/article/261fadd6de394c4e909ca5e76ae4df64
Autor:
Aram Vosoughi, Tuo Zhang, Kyrillus S. Shohdy, Panagiotis J. Vlachostergios, David C. Wilkes, Bhavneet Bhinder, Scott T. Tagawa, David M. Nanus, Ana M. Molina, Himisha Beltran, Cora N. Sternberg, Samaneh Motanagh, Brian D. Robinson, Jenny Xiang, Xiao Fan, Wendy K. Chung, Mark A. Rubin, Olivier Elemento, Andrea Sboner, Juan Miguel Mosquera, Bishoy M. Faltas
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
The role of germline variation in human cancers is not fully understood. Here, the authors define the landscape of putative deleterious germline variants that abrogate tumor suppressor proteins in advanced urothelial cancer patients.
Externí odkaz:
https://doaj.org/article/841aaee60ec54eb68cb48ba20fbccfd4