Výsledky vyhledávání - "N Shaun B Thomas"

Akademický článek

Proteomic and protein interaction network analysis of human T lymphocytes during cell‐cycle entry

Autor: Stephen J Orr, Daniel R Boutz, Rong Wang, Constantinos Chronis, Nicholas C Lea, Thivyan Thayaparan, Emma Hamilton, Hanna Milewicz, Eric Blanc, Ghulam J Mufti, Edward M Marcotte, N Shaun B Thomas

Publikováno v: Molecular Systems Biology, Vol 8, Iss 1, Pp 1-14 (2012)

Abstract Regulating the transition of cells such as T lymphocytes from quiescence (G0) into an activated, proliferating state involves initiation of cellular programs resulting in entry into the cell cycle (proliferation), the growth cycle (blastogen

Externí odkaz: https://doaj.org/article/b00ed918a60640089f0e436871a48e25

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Supplementary Figure 1 from Interaction with Vascular Endothelium Enhances Survival in Primary Chronic Lymphocytic Leukemia Cells via NF-κB Activation and De novo Gene Transcription

Autor: Stephen Devereux, Chris Fegan, Ghulam J. Mufti, N. Shaun B. Thomas, Deborah Yallop, Najeem'deen Folarin, Jane Moorhead, Satyen Gohil, Saman Hewamana, Piers E.M. Patten, Chris Pepper, Andrea G.S. Buggins

Supplementary Figure 1 from Interaction with Vascular Endothelium Enhances Survival in Primary Chronic Lymphocytic Leukemia Cells via NF-κB Activation and De novo Gene Transcription

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::703741943b33c7b925497516d46eaba8
https://doi.org/10.1158/0008-5472.22384823

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Supplementary Table 2 from Interaction with Vascular Endothelium Enhances Survival in Primary Chronic Lymphocytic Leukemia Cells via NF-κB Activation and De novo Gene Transcription

Supplementary Table 2 from Interaction with Vascular Endothelium Enhances Survival in Primary Chronic Lymphocytic Leukemia Cells via NF-κB Activation and De novo Gene Transcription

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b01ee17b3067fd7c8f52b1c06797743c
https://doi.org/10.1158/0008-5472.22384814.v1

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Supplementary Figure 2 from Interaction with Vascular Endothelium Enhances Survival in Primary Chronic Lymphocytic Leukemia Cells via NF-κB Activation and De novo Gene Transcription

Supplementary Figure 2 from Interaction with Vascular Endothelium Enhances Survival in Primary Chronic Lymphocytic Leukemia Cells via NF-κB Activation and De novo Gene Transcription

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cdc8f703bdb433efad57b0ef7f6e88f
https://doi.org/10.1158/0008-5472.22384820.v1

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Supplementary Procedures, Figures 1-4 from BCL-2 and Mutant NRAS Interact Physically and Functionally in a Mouse Model of Progressive Myelodysplasia

Supplementary Procedures, Figures 1-4 from BCL-2 and Mutant NRAS Interact Physically and Functionally in a Mouse Model of Progressive Myelodysplasia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29d4c7c5e2e031eab849820851121c9c
https://doi.org/10.1158/0008-5472.22370435.v1

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Supplementary Table 1 from Interaction with Vascular Endothelium Enhances Survival in Primary Chronic Lymphocytic Leukemia Cells via NF-κB Activation and De novo Gene Transcription

Supplementary Table 1 from Interaction with Vascular Endothelium Enhances Survival in Primary Chronic Lymphocytic Leukemia Cells via NF-κB Activation and De novo Gene Transcription

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d23012ee2bd5ead2eb6ae1575787a94
https://doi.org/10.1158/0008-5472.22384817

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Data from BCL-2 and Mutant NRAS Interact Physically and Functionally in a Mouse Model of Progressive Myelodysplasia

Myelodysplastic syndromes (MDS) are clonal stem cell hematologic disorders that evolve to acute myeloid leukemia (AML) and thus model multistep leukemogenesis. Activating RAS mutations and overexpression of BCL-2 are prognostic features of MDS/AML tr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6574856612cc768f5262dc91eb8974be
https://doi.org/10.1158/0008-5472.c.6496400

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Short loop functional commonality identified in leukaemia proteome highlights crucial protein sub-networks

Autor: Joseph Chi Fung Ng, Anna Laddach, Sun Sook Chung, Franca Fraternali, N. Shaun B. Thomas

Publikováno v: NAR Genomics and Bioinformatics

Direct drug targeting of mutated proteins in cancer is not always possible and efficacy can be nullified by compensating protein–protein interactions (PPIs). Here, we establish an in silico pipeline to identify specific PPI sub-networks containing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52131586812e0c5920dbdee278309b68
https://doi.org/10.1093/nargab/lqab010

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Discovery of Potent, Isoform-Selective Inhibitors of Histone Deacetylase Containing Chiral Heterocyclic Capping Groups and a N-(2-Aminophenyl)benzamide Binding Unit

Autor: Lena Shukla, Nermina Lamadema, Stephen John Atkinson, Elena Yiannaki, N. Shaun B. Thomas, Peter Ernest Soden, Charles M. Marson, Christopher J Matthews

Publikováno v: Journal of Medicinal Chemistry. 56:6156-6174

The synthesis of a novel series of potent chiral inhibitors of histone deacetylase (HDAC) is described that contain a heterocyclic capping group and a N-(2-aminophenyl)benzamide unit that binds in the active site. In vitro assays for the inhibition o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68212c595a2ab9118944c03fee35abb7
https://doi.org/10.1021/jm400634n

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Deep phenotyping of Tregs identifies an immune signature for idiopathic aplastic anemia and predicts response to treatment

Publikováno v: Kordasti, S, Costantini, B, Seidl, T, Perez Abellan, P, Martinez Llordella, M, Mclornan, D, Diggins, K E, Kulasekararaj, A, Benfatto, C, Feng, X, Smith, A, Mian, S A, Melchiotti, R, De Rinaldis, E D, Ellis, R, Petrov, N, Povoleri, G A M, Chung, S S, Thomas, N S B, Farzaneh, F, Irish, J M, Heck, S, Young, N S, Marsh, J C W & Mufti, G J 2016, ' Deep-phenotyping of Tregs identifies an immune signature for idiopathic aplastic anemia and predicts response to treatment ', Blood, vol. 128, no. 9, pp. 1193-1205 . https://doi.org/10.1182/blood-2016-03-703702

Idiopathic aplastic anemia (AA) is an immune-mediated and serious form of bone marrow failure. Akin to other autoimmune diseases, we have previously shown that in AA regulatory T-cells (Tregs) are reduced in number and function. The aim of this study

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce76c670700366d15af9895335188199
https://pubmed.ncbi.nlm.nih.gov/27587862

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