Zobrazeno 1 - 10
of 908
pro vyhledávání: '"N Segal"'
Autor:
Charissa C. Naidoo, Rouxjeane Venter, Francesc Codony, Gemma Agustí, Natasha Kitchin, Selisha Naidoo, Hilary Monaco, Hridesh Mishra, Yonghua Li, Jose C. Clemente, Robin M. Warren, Leopoldo N. Segal, Grant Theron
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract DNA characterisation in people with tuberculosis (TB) is critical for diagnostic and microbiome evaluations. However, extracellular DNA, more frequent in people on chemotherapy, confounds results. We evaluated whether nucleic acid dyes [prop
Externí odkaz:
https://doaj.org/article/74ec4169bc7344518d316f9672c00713
Autor:
Tinaye L. Chiyaka, Georgina R. Nyawo, Charissa C. Naidoo, Suventha Moodley, Jose C. Clemente, Stephanus T. Malherbe, Robin M. Warren, David N. Ku, Leopoldo N. Segal, Grant Theron
Publikováno v:
Annals of Clinical Microbiology and Antimicrobials, Vol 23, Iss 1, Pp 1-8 (2024)
Abstract Background Tuberculosis (TB), a major cause of disease and antimicrobial resistance, is spread via aerosols. Aerosols have diagnostic potential and airborne-microbes other than Mycobacterium tuberculosis complex (MTBC) may influence transmis
Externí odkaz:
https://doaj.org/article/955ee3b6f2b74408a29aa176f64b7d47
Autor:
Clea R. Barnett, Kelsey Krolikowski, Radu Postelnicu, Vikramjit Mukherjee, Imran Sulaiman, Matthew Chung, Luis Angel, Jun-Chieh J. Tsay, Benjamin G. Wu, Stephen T. Yeung, Ralf Duerr, Ludovic Desvignes, Kamal Khanna, Yonghua Li, Rosemary Schluger, Samaan Rafeq, Destiny Collazo, Yaa Kyeremateng, Nancy Amoroso, Deepak Pradhan, Sanchita Das, Laura Evans, Timothy M. Uyeki, Elodie Ghedin, Gregg J. Silverman, Leopoldo N. Segal, Shari B. Brosnahan
Publikováno v:
ERJ Open Research, Vol 10, Iss 4 (2024)
Introduction Mounting evidence indicates that an individual's humoral adaptive immune response plays a critical role in the setting of SARS-CoV-2 infection, and that the efficiency of the response correlates with disease severity. The relationship be
Externí odkaz:
https://doaj.org/article/328d2aa670f74aefa54a2b44011cd123
Autor:
Vikramjit Mukherjee, MD, FRCP, Radu Postelnicu, MD, Chelsie Parker, MS, Patrick S. Rivers, PhD, George L. Anesi, MD, MSCE, MBE, Adair Andrews, RN, MATD, Erin Ables, MA, Eric D. Morrell, MD, MA, David M. Brett-Major, MD, MPH, M. Jana Broadhurst, MD, PhD, J. Perren Cobb, MD, Amy Irwin, DNP, RN, Christopher J. Kratochvil, MD, Kelsey Krolikowski, BA, Vishakha K. Kumar, MD, MBA, Douglas P. Landsittel, PhD, Richard A. Lee, MD, Janice M. Liebler, MD, Leopoldo N. Segal, MD, Jonathan E. Sevransky, MD, MHS, Avantika Srivastava, MS, Timothy M. Uyeki, MD, MPH, Mark M. Wurfel, MD, PhD, David Wyles, MD, Laura E. Evans, MD, MSc, Karen Lutrick, PhD, Pavan K. Bhatraju, MD, MSc, on behalf of the Severe Acute Respiratory Infection-Preparedness (SARI-PREP) Study Group
Publikováno v:
Critical Care Explorations, Vol 6, Iss 7, p e1122 (2024)
IMPORTANCE:. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has evolved through multiple phases in the United States, with significant differences in patient centered outcomes with improvements in hospital strain, medical c
Externí odkaz:
https://doaj.org/article/40d4a8c263284e60ad1b0d3e293f20b0
Autor:
Igor Dolgalev, Hua Zhou, Nina Murrell, Hortense Le, Theodore Sakellaropoulos, Nicolas Coudray, Kelsey Zhu, Varshini Vasudevaraja, Anna Yeaton, Chandra Goparaju, Yonghua Li, Imran Sulaiman, Jun-Chieh J. Tsay, Peter Meyn, Hussein Mohamed, Iris Sydney, Tomoe Shiomi, Sitharam Ramaswami, Navneet Narula, Ruth Kulicke, Fred P. Davis, Nicolas Stransky, Gromoslaw A. Smolen, Wei-Yi Cheng, James Cai, Salman Punekar, Vamsidhar Velcheti, Daniel H. Sterman, J. T. Poirier, Ben Neel, Kwok-Kin Wong, Luis Chiriboga, Adriana Heguy, Thales Papagiannakopoulos, Bettina Nadorp, Matija Snuderl, Leopoldo N. Segal, Andre L. Moreira, Harvey I. Pass, Aristotelis Tsirigos
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Approximately 30% of early-stage lung adenocarcinoma patients present with disease progression after successful surgical resection. Despite efforts of mapping the genetic landscape, there has been limited success in discovering predictive bi
Externí odkaz:
https://doaj.org/article/326ae301e3024de2b6652801e0ebede8
Autor:
Suventha Moodley, Elouise Kroon, Charissa C. Naidoo, Georgina R. Nyawo, Benjamin G. Wu, Selisha Naidoo, Tinaye L. Chiyaka, Happy Tshivhula, Shivani Singh, Yonghua Li, Robin M. Warren, Eileen G. Hoal, Erwin Schurr, Jose C. Clemente, Leopoldo N. Segal, Marlo Möller, Grant Theron
Publikováno v:
Microorganisms, Vol 12, Iss 6, p 1048 (2024)
Latent tuberculosis infection (LTBI) is common in people living with HIV (PLHIV) in high-TB-burden settings. Active TB is associated with specific stool taxa; however, little is known about the stool microbiota and LTBI in PLHIV. We characterised the
Externí odkaz:
https://doaj.org/article/a23e96e43ae1419fa5913224f7908246
Autor:
Benjamin Kwok, Benjamin G. Wu, Ibrahim F. Kocak, Imran Sulaiman, Rosemary Schluger, Yonghua Li, Raheel Anwer, Chandra Goparaju, Daniel J. Ryan, Marla Sagatelian, Matthew S. Dreier, Vivek Murthy, Samaan Rafeq, Gaetane C. Michaud, Daniel H. Sterman, Jamie L. Bessich, Harvey I. Pass, Leopoldo N. Segal, Jun-Chieh J. Tsay
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Malignant pleural effusions (MPE) complicate malignancies and portend worse outcomes. MPE is comprised of various components, including immune cells, cancer cells, and cell-free DNA/RNA. There have been investigations into using these compon
Externí odkaz:
https://doaj.org/article/3fd0be5a995841c1b2fc7d1ba89ad295
Autor:
Brandilyn A. Peters, Harvey I. Pass, Robert D. Burk, Xiaonan Xue, Chandra Goparaju, Christopher C. Sollecito, Evan Grassi, Leopoldo N. Segal, Jun-Chieh J. Tsay, Richard B. Hayes, Jiyoung Ahn
Publikováno v:
Genome Medicine, Vol 14, Iss 1, Pp 1-17 (2022)
Abstract Background Cancer recurrence after tumor resection in early-stage non-small cell lung cancer (NSCLC) is common, yet difficult to predict. The lung microbiota and systemic immunity may be important modulators of risk for lung cancer recurrenc
Externí odkaz:
https://doaj.org/article/1038371a24ed466e9818cc40620c048c
Autor:
Chan Wang, Leopoldo N. Segal, Jiyuan Hu, Boyan Zhou, Richard B. Hayes, Jiyoung Ahn, Huilin Li
Publikováno v:
Microbiome, Vol 10, Iss 1, Pp 1-15 (2022)
Abstract Background With the rapid accumulation of microbiome-wide association studies, a great amount of microbiome data are available to study the microbiome’s role in human disease and advance the microbiome’s potential use for disease predict
Externí odkaz:
https://doaj.org/article/2216d7d9a1e144b1aa827a47ee6723bf
Autor:
Pavan K. Bhatraju, MD, MSc, Eric D. Morrell, MD, Ian B. Stanaway, PhD, Neha A. Sathe, MD, MSc, Avantika Srivastava, MS, Radu Postelnicu, MD, Richard Green, BS, Adair Andrews, BSN, Martin Gonzalez, BS, Christopher J. Kratochvil, MD, Vishakha K. Kumar, BS, Tien-Ying Hsiang, PhD, Michael Gale, Jr, PhD, George L. Anesi, MD, David Wyles, MD, M. Jana Broadhurst, MD, PhD, David Brett-Major, MD, MPH, Vikramjit Mukherjee, MD, Jonathan E. Sevransky, MD, Douglas Landsittel, PhD, Chi Hung, MD, William A. Altemeier, MD, Sina A. Gharib, MD, Timothy M. Uyeki, MD, MPH, J. Perren Cobb, MD, Janice M. Liebler, MD, David R. Crosslin, PhD, Gail P. Jarvik, MD, Leopoldo N. Segal, MD, Laura Evans, MD, Carmen Mikacenic, MD, Mark M. Wurfel, MD, PhD
Publikováno v:
Critical Care Explorations, Vol 5, Iss 1, p e0827 (2023)
IMPORTANCE:. Vascular dysfunction and capillary leak are common in critically ill COVID-19 patients, but identification of endothelial pathways involved in COVID-19 pathogenesis has been limited. Angiopoietin-like 4 (ANGPTL4) is a protein secreted in
Externí odkaz:
https://doaj.org/article/de84ce123a564b7b9fa872a7b541c824