Zobrazeno 1 - 10
of 19
pro vyhledávání: '"N S, Scrutton"'
Publikováno v:
Materials Today Bio
The proverbial phrase ‘you can’t get blood from a stone’ is used to describe a task that is practically impossible regardless of how much force or effort is exerted. This phrase is well-suited to humanity’s first crewed mission to Mars, which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9156622fc1b19ce043d914b91901d170
https://pubmed.ncbi.nlm.nih.gov/34604732
https://pubmed.ncbi.nlm.nih.gov/34604732
Autor:
J, Waller, H S, Toogood, V, Karuppiah, N J W, Rattray, D J, Mansell, D, Leys, J M, Gardiner, A, Fryszkowska, S T, Ahmed, R, Bandichhor, G P, Reddy, N S, Scrutton
Publikováno v:
Organicbiomolecular chemistry. 15(20)
Reduction of double bonds of α,β-unsaturated carboxylic acids and esters by ene-reductases remains challenging and it typically requires activation by a second electron-withdrawing moiety, such as a halide or second carboxylate group. We showed tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::aaaf333da46198defdc1ea50acf2c513
https://pubmed.ncbi.nlm.nih.gov/28485453
https://pubmed.ncbi.nlm.nih.gov/28485453
Autor:
H S, Toogood, S, Tait, A, Jervis, A, Ní Cheallaigh, L, Humphreys, E, Takano, J M, Gardiner, N S, Scrutton
Publikováno v:
Methods in enzymology. 575
The era of synthetic biology heralds in a new, more "green" approach to fine chemical and pharmaceutical drug production. It takes the knowledge of natural metabolic pathways and builds new routes to chemicals, enables nonnatural chemical production,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b9165ac67034e9148cc6fb7588cf7077
https://pubmed.ncbi.nlm.nih.gov/27417932
https://pubmed.ncbi.nlm.nih.gov/27417932
Publikováno v:
Synfacts
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b01afdf592ec20ccb06d3fa4870b581
https://doi.org/10.1055/s-0035-1560868
https://doi.org/10.1055/s-0035-1560868
Publikováno v:
The Biochemical journal. 359(Pt 2)
The side chain of residue Arg(238) in morphinone reductase (MR) is located close to the N-1/C-2 carbonyl region of the flavin isoalloxazine ring. During enzyme reduction negative charge develops in this region of the flavin. The positioning of a posi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f1164beba37f014002ed6e30d165839d
https://pubmed.ncbi.nlm.nih.gov/11583577
https://pubmed.ncbi.nlm.nih.gov/11583577
Publikováno v:
The Journal of biological chemistry. 276(46)
Recent evidence from isotope studies supports the view that catalysis by trimethylamine dehydrogenase (TMADH) proceeds from a Michaelis complex involving trimethylamine base and not, as thought previously, trimethylammonium cation. In native TMADH re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::af0be39da5cc10b4f20235483d596907
https://pubmed.ncbi.nlm.nih.gov/11553643
https://pubmed.ncbi.nlm.nih.gov/11553643
Publikováno v:
The Biochemical journal. 358(Pt 1)
The binding of CO to the murine inducible nitric oxide synthase (iNOS) oxygenase domain has been studied by laser flash photolysis. The effect of the (6R)-5,6,7,8-tetrahydro-L-biopterin (BH(4)) cofactor L-arginine and several Type I L-arginine analog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6da0ae6072f0f1a1cc888bd8688f8a17
https://pubmed.ncbi.nlm.nih.gov/11485568
https://pubmed.ncbi.nlm.nih.gov/11485568
Publikováno v:
The Journal of biological chemistry. 276(27)
His-172 and Tyr-169 are components of a triad in the active site of trimethylamine dehydrogenase (TMADH) comprising Asp-267, His-172, and Tyr-169. Stopped-flow kinetic studies with trimethylamine as substrate have indicated that mutation of His-172 t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d59daf0712bf9e64b8687ff0471cf95c
https://pubmed.ncbi.nlm.nih.gov/11304539
https://pubmed.ncbi.nlm.nih.gov/11304539
Publikováno v:
The Biochemical journal. 354(Pt 1)
A minigene encoding the C-terminal domain of the 2Fe rubredoxin of Pseudomonas oleovorans was created from the parental alk G gene contained in the expression plasmid pKK223-3. The vector directed the high-level production of the C-terminal domain of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d766b5aa38725c528169051b5dead58e
https://pubmed.ncbi.nlm.nih.gov/11171083
https://pubmed.ncbi.nlm.nih.gov/11171083
Publikováno v:
The Journal of biological chemistry. 276(9)
C-H bond breakage by tryptophan tryptophylquinone (TTQ)-dependent methylamine dehydrogenase (MADH) occurs by vibrationally assisted tunneling (Basran, J., Sutcliffe, M. J., and Scrutton, N. S. (1999) Biochemistry 38, 3218--3222). We show here a simil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f71f352c63585b220276ed364bb5ed60
https://pubmed.ncbi.nlm.nih.gov/11087744
https://pubmed.ncbi.nlm.nih.gov/11087744