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Akademický článek

STUDY OF NOOTROPIC AND ANTI-HYPOXIC ACTIVITY OF 5-AMINO-3-EXO-AZATRICYCLO[5.2.1.02,6]DECAN-4-ON

Autor: T. A. Sapozhnikova, N. S. Makara, S. F. Gabdrakhmanova, R. Yu. Khisamutdinova

Publikováno v: Разработка и регистрация лекарственных средств, Vol 8, Iss 1, Pp 86-90 (2019)

Introduction. Nootropic drugs are components of complex therapy for various neurological dysfunctions. One of the classes of ND are pyrrolidone derivatives, which, in addition to a direct effect on cognitive functions, increase the brain's resistance

Externí odkaz: https://doaj.org/article/33afa7e8a5fb406ea9218065ebf0fdf5

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Methylation of Quercetin by Diazomethane and Hypoglycemic Activity of its Tetra-O-Methyl Ether

Autor: E. R. Karimova, T. A. Sapozhnikova, S. F. Gabdrakhmanova, N. S. Makara, Leonid V. Spirikhin, Baltina Lidiya A

Publikováno v: Chemistry of Natural Compounds. 56:837-841

The tetra-O-methyl ether of quercetin (QU) 3 (54%), 3,7,4′-tri-O-methyl ether 4 (30%), and a previously unreported 3,7,3-tri-O-methyl ether of QU 5 (7%) were obtained via methylation of QU by an excess of diazomethane in dioxane. Their structures w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f812c502f6ee7b516c9daf7b32834fc8
https://doi.org/10.1007/s10600-020-03164-2

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Synthesis and Anti-Inflammatory and Antiulcer Activity of a Glycyrrhizic Acid Conjugate with L-Phenylalanine Methyl Ester

Autor: T. A. Sapozhnikova, Baltina Lidiya A, F. A. Zarudii, S. F. Gabdrakhmanova, N. S. Makara, R. M. Kondratenko

Publikováno v: Pharmaceutical Chemistry Journal. 54:225-228

A conjugate of glycyrrhizic acid (GA) with L-phenylalanine methyl ester was synthesized using N-hydroxysuccinimide and 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide. Chemical modification of GA via addition of L-phenylalanine methyl ester moieties in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f1389611ef22f91556f6b1cd0e18e836
https://doi.org/10.1007/s11094-020-02184-0

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Hypoglycemic Activity of Glycyrrhizic Acid and Some of its Derivatives in the Alloxan Diabetes Model in Rats

Autor: L. A. Baltina, T. A. Sapozhnikova, S. F. Gabdrakhmanova, N. S. Makara, R. Yu. Khisamutdinova, L. A. Baltina, Jr, S. F. Petrova, D. R. Saifullina, R. M. Kondratenko

Publikováno v: Pharmaceutical Chemistry Journal.

The hypoglycemic activity of glycyrrhizic acid (GA, I), its trisodium (II) and sodium-dilithium salts (III), and a conjugate with L-methionine methyl ester (IV) was studied using an alloxan diabetes model after peroral administration to male Wistar r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5e98e0f39fa5d19ed6e27ca0fa3d1138
https://doi.org/10.1007/s11094-021-02424-x

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Paeoniflorin benzoates: synthesis and influence on learning and memory of aged rats in the passive avoidance task

Autor: N. S. Makara, T. A. Sapozhnikova, Lidia A. Baltina, R. M. Kondratenko, S. F. Gabdrakhmanova, Lia A. Baltina

Publikováno v: Natural Product Research. 35:2668-2676

Paeoniflorin per-O-benzoates with the preserved pinane structure 2 and rearranged aglycone 3, containing C4 = O function, were obtained and their influence on learning and memory of aged rats was studied in the passive avoidance task. It was found th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14b0f7bad7f3a0e819c11f7d1cc61c2d
https://doi.org/10.1080/14786419.2019.1662005

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Variation of spacer type and topology of phenyl moiety in 2-pyridone core of 4-oxo-3-N-methylcytisine; effect of synthesized compounds on rat’s behavior in conditioned passive avoidance reflex (CPAR) test

Autor: T. A. Sapozhnikova, A. V. Koval’skaya, Inna P. Tsypysheva, P. R. Petrova, Alexander N. Lobov, N. S. Makara, F. S. Zarudii, S. F. Gabdrakhmanova

Publikováno v: Natural Product Research. 35:207-215

Novel derivatives of 4-oxo-3-methylcytisine with phenyl moiety bonded to starting molecule through various spacers were obtained from the 9-amino, -halo, -formyl and 11-halo precursors by reductive alkylation of amines, generation of amide, as well a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6c8d36eebc06ac4473dc226442f69f2e
https://doi.org/10.1080/14786419.2019.1622106

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Nootropic Activity of a Novel (-)-Cytisine Derivative (3aR,4S,8S,12R, 12aS,12bR)-10-Methyl-2-Phenyloctahydro-1H-4,12a-Etheno-8,12-Methanopyrrolo[3’,4’:3,4]Pyrido[1,2-a] [1,5]Diazocine-1,3,5(4H)-Trione

Autor: P. R. Petrova, N. S. Makara, F. S. Zarudii, Sophia S. Borisevich, C L. Khursan, R. Yu. Khisamutdinova, T. A. Sapozhnikova, Inna P. Tsypysheva, A. V. Koval’skaya

Publikováno v: Bulletin of Experimental Biology and Medicine. 164:434-438

We performed screening of nootropic properties of 10 new derivatives of quinolizidine alkaloid (-)-cytisine. Compounds with β-endo stereochemistry were more active than α-endo-isomers. Under stress conditions (3aR,4S,8S,12R,12aS,12bR)-10-methyl-2-p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c93d04e39d5b6ae9cf329a88e2f8b25f
https://doi.org/10.1007/s10517-018-4006-0

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