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Renin inhibitors. Syntheses of subnanomolar, competitive, transition-state analogue inhibitors containing a novel analogue of statine

Autor: J, Boger, L S, Payne, D S, Perlow, N S, Lohr, M, Poe, E H, Blaine, E H, Ulm, T W, Schorn, B I, LaMont, T Y, Lin

Publikováno v: Journal of medicinal chemistry. 28(12)

Analogues of the renin octapeptide substrate were synthesized in which replacement of the scissile dipeptide with (3S,4S)-4-amino-3-hydroxy-6-methylheptanoic acid (statine, Sta) transformed the substrate sequence into potent, transition-state analogu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d25555479b6c710c8eedef351672e520
https://pubmed.ncbi.nlm.nih.gov/3906131

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ChemInform Abstract: Renin Inhibitors. Syntheses of Subnanomolar, Competitive, Transition-State Analogue Inhibitors Containing a Novel Analogue of Statine

Autor: M. Kawai, T.-Y. Lin, LaMont Bi, Linda S. Payne, Daniel H. Rich, Joshua S. Boger, Debra S. Perlow, N. S. Lohr, Terry W. Schorn, D. F. Veber, Edward H. Blaine, Edgar H. Ulm, M. Poe

Publikováno v: Chemischer Informationsdienst. 17

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::44698f53eefbd738d6c3e9f9137dc6bc
https://doi.org/10.1002/chin.198613321

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ChemInform Abstract: REDUCTIVE AMINATION OF ETHYL 2-OXO-4-PHENYLBUTANOATE WITH L-ALANYL-L-PROLINE. SYNTHESIS OF ENALAPRIL MALEATE

Autor: M. J. WYVRATT, E. W. TRISTRAM, T. J. IKELER, N. S. LOHR, H. JOSHUA, J. P. SPRINGER, B. H. ARISON, A. A. PATCHETT

Publikováno v: Chemischer Informationsdienst. 15

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b9a6f12e2a23e47780d908a987f253b0
https://doi.org/10.1002/chin.198451212

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