Výsledky vyhledávání - "N R, Nirmala"

Whole-Exome Sequencing Reveals Overlap Between Macrophage Activation Syndrome in Systemic Juvenile Idiopathic Arthritis and Familial Hemophagocytic Lymphohistiocytosis

Autor: Joseph D. Szustakowski, Kenneth M. Kaufman, N. R. Nirmala, Alexandra H. Filipovich, Fan Yang, Alexei A. Grom, Ammar Husami, Ndate Fall, John B. Harley, Bolan Linghu, Kejian Zhang

Publikováno v: Arthritis & Rheumatology. 66:3486-3495

Objective Macrophage activation syndrome (MAS), a life-threatening complication of systemic juvenile idiopathic arthritis (JIA), resembles familial hemophagocytic lymphohistiocytosis (HLH), a constellation of autosomal-recessive immune disorders resu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3cb4bf0ce72fb6a771b38e632eda7855
https://doi.org/10.1002/art.38793

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Canakinumab reverses overexpression of inflammatory response genes in tumour necrosis factor receptor-associated periodic syndrome

Autor: Roberta Caorsi, Rebecca I. Torene, Sandrine Starck-Schwertz, Marco Cattalini, Laura Obici, Marco Gattorno, N. R. Nirmala, V. Tormey, Helen J. Lachmann, Ken Abrams, Martin Letzkus, Nicole Hartmann

Publikováno v: Annals of the Rheumatic Diseases

ObjectiveTo explore whether gene expression profiling can identify a molecular mechanism for the clinical benefit of canakinumab treatment in patents with tumour necrosis factor receptor-associated periodic syndrome (TRAPS).MethodsBlood samples were

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab722bb88f55794f9695f2f33aa3c0c8
http://hdl.handle.net/10379/14182

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Trends and impact of genome mining patents on target discovery

Autor: N. R. Nirmala, Richard Cai

Publikováno v: Expert Opinion on Therapeutic Patents. 18:563-568

Background: The advent of genome sequencing has brought about an explosion in the content of sequence databases. To date, more than 70 mammalian genomes are or will be available. In the pharmaceutical context, this important advancement opens up the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fcfc946f70bc11aa15001d00c3ad99e7
https://doi.org/10.1517/13543776.18.6.563

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Gene-expression analysis of adult-onset Still’s disease and systemic juvenile idiopathic arthritis is consistent with a continuum of a single disease entity

Autor: Jan Zernicke, Eugen Feist, Guido Junge, Arndt Brachat, Christof Specker, M. Witt, N. R. Nirmala, Alberto Martini, Norbert Blank

Publikováno v: Pediatric Rheumatology Online Journal

Background: Adult-onset Still’s disease (AOSD), a rare autoinflammatory disorder, resembles systemic juvenile idiopathic arthritis (SJIA). The superimposable systemic clinical features of AOSD and SJIA suggest both clinical phenotypes represent the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a1ed8a87381a9c9a94784e219f9ec42
https://doi.org/10.1186/s12969-015-0047-3

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Genes responding to Canakinumab therapy in SJIA are -inversely - disregulated in adult onset Still's disease

Autor: A Martini, Norbert Blank, M. Witt, Frank Behrens, N. R. Nirmala, Guido Junge, Christof Specker, Jan Zernicke, Eugen Feist, Arndt Brachat

Publikováno v: Pediatric Rheumatology Online Journal

Adult-onset Still's disease (AOSD) is a rare auto-inflammatory disorder resembling a similar pediatric syndrome known as systemic juvenile idiopathic arthritis (SJIA).[1] The superimposable systemic and clinical features in SJIA and AOSD suggest that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7905498cfbb5f2fe2aef0503b32e76a5
https://doi.org/10.1186/1546-0096-13-s1-p4

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Expression and Characterization of a 5-oxo-6E,8Z,11Z,14Z-Eicosatetraenoic Acid Receptor Highly Expressed on Human Eosinophils and Neutrophils

Autor: Suzanne Holden, Peter Finan, N. R. Nirmala, Jonathan J. Turner, Klaus Seuwen, Steven J. Charlton, Laurent Tenaillon, Pamela Tranter, Umesh Bhatia, Carol E. Jones, Rachel Kettle, Gabor Jarai, Rochdi Bouhelal

Publikováno v: Molecular Pharmacology. 63:471-477

Using a bioinformatics approach, we have isolated a novel G-protein-coupled receptor (GPCR), R527, and have demonstrated that this receptor shows no significant homology to previously deorphanized GPCRs. Quantitative reverse transcription-polymerase

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8c2c30ba2eb502c537bb36178624c73
https://doi.org/10.1124/mol.63.3.471

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Biomarkers in systemic juvenile idiopathic arthritis: a comparison with biomarkers in cryopyrin-associated periodic syndromes

Autor: Hermann Gram, Alexei A. Grom, N. R. Nirmala

Publikováno v: Current opinion in rheumatology. 26(5)

PURPOSE OF REVIEW: This review summarizes biomarkers in systemic juvenile idiopathic arthritis (sJIA). Broadly, the markers are classified under protein, cellular, gene expression and genetic markers. We also compare the biomarkers in sJIA to biomark

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::823a9eb78439d5f2b1bf0d855c2e9237
https://pubmed.ncbi.nlm.nih.gov/25050926

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Whole-exome sequencing reveals overlap between macrophage activation syndrome in systemic juvenile idiopathic arthritis and familial hemophagocytic lymphohistiocytosis

Autor: Kenneth M, Kaufman, Bolan, Linghu, Joseph D, Szustakowski, Ammar, Husami, Fan, Yang, Kejian, Zhang, Alexandra H, Filipovich, Ndate, Fall, John B, Harley, N R, Nirmala, Alexei A, Grom

Publikováno v: Arthritisrheumatology (Hoboken, N.J.). 66(12)

Macrophage activation syndrome (MAS), a life-threatening complication of systemic juvenile idiopathic arthritis (JIA), resembles familial hemophagocytic lymphohistiocytosis (HLH), a constellation of autosomal-recessive immune disorders resulting from

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::98002b8f195659d68c238c82165ddf51
https://pubmed.ncbi.nlm.nih.gov/25047945

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Heterologously expressed inner lipoyl domain of dihydrolipoyl acetyltransferase inhibits ATP-dependent inactivation of pyruvate dehydrogenase complex

Autor: Bing Yan, Sid Topiol, Thomas Daniel Aicher, Carol J. Dragland, Vijayayakumar Sundararajan, John C. Jackson, William R. Mann, John E. Blume, Philip A. Bell, Paul Ramage, Christine C. Vinluan, John S. Gounarides, N. R. Nirmala

Publikováno v: Biochemical Journal. 334:703-711

The activity of the pyruvate dehydrogenase multienzyme complex (PDC), which catalyses the oxidation of pyruvate to acetyl-CoA within the mitochondrion, is diminished in animal models of diabetes. Studies with purified PDC components have suggested th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::405c028ae9929d1cb5f403e9247ed185
https://doi.org/10.1042/bj3340703

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Sequence-specific proton and nitrogen-15 resonance assignments for human dihydrofolate reductase in solution

Autor: N. R. Nirmala, James H. Freisheim, Tavner J. Delcamp, Gerhard Wagner, Brian J. Stockman, Michael T. DeYarman

Publikováno v: Biochemistry. 31:218-229

Dihydrofolate reductase is an intracellular target enzyme for folate antagonists, including the anticancer drug methotrexate. In order to design novel drugs with altered binding properties, a detailed description of protein-drug interactions in solut

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dbeba922760a5fea694d4b0acdc04179
https://doi.org/10.1021/bi00116a031

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