Zobrazeno 1 - 10
of 91
pro vyhledávání: '"N R, Bachur"'
Publikováno v:
Anti-cancer drug design. 14(1)
Certain DNA minor groove binding agents, distamycin, netropsin, and a series of anticancer bis-benzimidazoles can block DNA helicase activity by binding to duplex DNA at specific base sequences. DNA helicases are crucial to cell DNA replication, tran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::53cb616965677344834535ebf22fc1a0
https://pubmed.ncbi.nlm.nih.gov/10363025
https://pubmed.ncbi.nlm.nih.gov/10363025
Publikováno v:
Molecular pharmacology. 44(5)
DNA-binding antibiotics such as intercalators, narrow groove binders, and other substances modify duplex DNA, making it an altered substrate for DNA helicases. The intercalators daunorubicin, actinomycin D, echinomycin, and elsamicin, the narrow groo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::29ec235ecef8755990845e0786bed93f
https://pubmed.ncbi.nlm.nih.gov/8246909
https://pubmed.ncbi.nlm.nih.gov/8246909
Publikováno v:
Molecular pharmacology. 41(6)
Helicases are essential to both DNA replication and transcription because they separate double-stranded DNA, preparing the single strands for replication or transcription. Because the anti-cancer anthracycline antibiotics stabilize double-stranded DN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7acb00d2fe9d67bd5c1a49d58ad4de11
https://pubmed.ncbi.nlm.nih.gov/1614415
https://pubmed.ncbi.nlm.nih.gov/1614415
Publikováno v:
Journal of Chromatography A. 205:482-485
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::326f37e84623f1afdca9d50e2c5a6e6c
https://doi.org/10.1016/s0021-9673(00)82682-5
https://doi.org/10.1016/s0021-9673(00)82682-5
Publikováno v:
Investigational New Drugs. 3:361-368
The pharmacokinetics of esorubicin, a new anthracycline antibiotic, was investigated in conjunction with a phase I clinical trial. The drug was administered to 12 patients as an intravenous bolus at a dose of 20 to 40 mg/m2. All patients had normal r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2af4cef7abbb76fb5127575da09b25bd
https://doi.org/10.1007/bf00170759
https://doi.org/10.1007/bf00170759
Publikováno v:
Journal of Biological Chemistry. 259:959-966
Under anaerobic conditions and with proper electron donors, NADPH-cytochrome P-450 reductase (EC 1.6.2.4) and xanthine oxidase (EC 1.2.3.2) similarly reductively metabolized mitomycin C. Reversed phase high performance liquid chromatography was used
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1de810c4bd44b5334d2888ae1352c71a
https://doi.org/10.1016/s0021-9258(17)43551-4
https://doi.org/10.1016/s0021-9258(17)43551-4
Publikováno v:
Journal of Biological Chemistry. 252:2961-2966
Affinity-purified phytohemagglutinin from red kidney bean resolves into five isolectins by SP-Sephadex ion exchange chromatography. Recoveries ranging from 30 to 130 mg of protein for each isolectin are easily achieved. The isolectins have similar am
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::854ad0158280ccc18b8bf735a89ba32b
https://doi.org/10.1016/s0021-9258(17)40456-x
https://doi.org/10.1016/s0021-9258(17)40456-x
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 211:337-344
The preparation and properties of a Mg2+-dependent, (Na+ + K+)-stimulated ATPase from platelets are described. The enzym system require Mg2+ for activity, is stimulated maximally by the presence of Na+ and K+ in a ratio of 11.5/1, has a pH optimum 7.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::40e16cf5e561e6a617dad2142f63cb02
https://doi.org/10.1016/0005-2736(70)90106-9
https://doi.org/10.1016/0005-2736(70)90106-9
Autor:
N R, Bachur
Publikováno v:
Cancer treatment reports. 63(5)
The anthracycline antibiotics show evidence of numerous interactions with cellular components and participation in several metabolic pathways. Small structural changes in the antibiotic molecule can produce major changes in intracellular localization
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8b8227cc0b26d5c9c8a160457ad507a8
https://pubmed.ncbi.nlm.nih.gov/455323
https://pubmed.ncbi.nlm.nih.gov/455323
Autor:
S D, Reich, N R, Bachur
Publikováno v:
Cancer research. 36(10)
Adriamycin dosage should be reduced in patients with impaired liver function, since adriamycin disposition is influenced by liver metabolism and biliary excretion. It follows that drugs that increase the metabolism or excretory capacity of the liver
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::544ef869a154010a69e1b85c8b7f27bf
https://pubmed.ncbi.nlm.nih.gov/954004
https://pubmed.ncbi.nlm.nih.gov/954004