Zobrazeno 1 - 10
of 42
pro vyhledávání: '"N R, Alpert"'
Publikováno v:
Journal of Cardiovascular Pharmacology. 26:45-51
Calcium sensitizers may influence myocardial energetics by their action on calcium turnover and on crossbridge behavior. Using a myothermal method, the effects of the Ca2+ sensitizer EMD-53998 on calcium cycling, crossbridge behavior, and myocardial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53a35bd0954089169df85111b1ef2be2
https://doi.org/10.1097/00005344-199506261-00006
https://doi.org/10.1097/00005344-199506261-00006
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 263:H503-H510
2,3-Butanedione monoxime (BDM) exerts a marked negative inotropic effect and has been shown to have protective actions on human myocardial force production that may be of clinical use. To determine the underlying mechanisms, we studied the effects of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bd69f6e953c50ed4e64489659216915
https://doi.org/10.1152/ajpheart.1992.263.2.h503
https://doi.org/10.1152/ajpheart.1992.263.2.h503
Publikováno v:
Journal of muscle research and cell motility. 21(7)
Familial hypertrophic cardiomyopathy (FHC) is a disease of the sarcomere. In the beta-myosin heavy chain gene, which codes for the mechanical enzyme myosin, greater than 40 point mutations have been found that are causal for this disease. We have stu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::805384a0fe9d96e12492c74facbbff15
https://pubmed.ncbi.nlm.nih.gov/11227787
https://pubmed.ncbi.nlm.nih.gov/11227787
Publikováno v:
Heart rate as a determinant of cardiac function ISBN: 9783642470721
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::09523c8a836c151bf5d58d876d0ef757
https://doi.org/10.1007/978-3-642-47070-7_2
https://doi.org/10.1007/978-3-642-47070-7_2
Autor:
J N, Peterson, N R, Alpert
Publikováno v:
Advances in experimental medicine and biology. 453
The mechanical characteristics of the myosin motor is one of the key determinants of ventricular function. In small mammals there are two myosin isoforms, V1 and V3, with profoundly different performance characteristics. We used myothermal and mechan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4ea23aa714166f27d8cec0df7422abe5
https://pubmed.ncbi.nlm.nih.gov/9889821
https://pubmed.ncbi.nlm.nih.gov/9889821
Publikováno v:
Alterations of Excitation-Contraction Coupling in the Failing Human Heart ISBN: 9783642486722
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::450799f663d7ced4ad5d12135e1f39e8
https://doi.org/10.1007/978-3-642-48670-8_13
https://doi.org/10.1007/978-3-642-48670-8_13
Autor:
N R, Alpert, L A, Mulieri
Publikováno v:
Advances in experimental medicine and biology. 430
Thin muscle strips were obtained from non-failing (NF) and failing (dilated cardiomyopathy (DCM)) hearts, using a new harvesting and dissection technique. The strips were used to carry out a myothermal and mechanical analysis so that contractile and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::14664bd433278079431095e1159ec6df
https://pubmed.ncbi.nlm.nih.gov/9330722
https://pubmed.ncbi.nlm.nih.gov/9330722
Publikováno v:
Basic research in cardiology. 88
Under normal conditions the cardiac output is designed to meet the metabolic needs of the organism. Thus, the demands imposed on the heart muscle can range from low values at rest to an order of magnitude greater values during exercise. The heart use
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1f6b5ba27cfeede44b564e31c974d410
https://pubmed.ncbi.nlm.nih.gov/8147834
https://pubmed.ncbi.nlm.nih.gov/8147834
Publikováno v:
Advances in experimental medicine and biology. 346
Isometric force, heat output, and aequorin light emission were measured in isolated muscle strips from nonfailing human hearts and from hearts with endstage failing dilated cardiomyopathy (37 degrees C; 30-180 beats per minute (bpm)). In nonfailing m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3036eaf522aa9097a4c146d06cd3dcc6
https://pubmed.ncbi.nlm.nih.gov/8184784
https://pubmed.ncbi.nlm.nih.gov/8184784
Publikováno v:
Basic research in cardiology. 88
Myocardial adaptation to stress and development includes reorganization of subcellular systems. Using a myothermal method, changes in the contractile protein system were investigated across species (rat, rabbit, human myocardium) and in consequence o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2bb3e51cda74c6ddc92b95f734f14a3e
https://pubmed.ncbi.nlm.nih.gov/8147839
https://pubmed.ncbi.nlm.nih.gov/8147839