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Murine tumor cells transduced with the gene for tumor necrosis factor-alpha. Evidence for paracrine immune effects of tumor necrosis factor against tumors

Autor: A L Asher, J J Mulé, A Kasid, N P Restifo, J C Salo, C M Reichert, G Jaffe, B Fendly, M Kriegler, S A Rosenberg

Publikováno v: The Journal of Immunology. 146:3227-3234

Studies of the anti-tumor activity of TNF-alpha in vivo have been hampered by the need to administer systemically toxic doses of the cytokine to obtain a curative response. To facilitate studies of the effect of high local concentrations of TNF-alpha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::914cab4e99ea88d561fe7b2474d052eb
https://doi.org/10.4049/jimmunol.146.9.3227

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Elucidating the autoimmune and antitumor effector mechanisms of a treatment based on cytotoxic T lymphocyte antigen-4 blockade in combination with a B16 melanoma vaccine: comparison of prophylaxis and therapy

Autor: A, van Elsas, R P, Sutmuller, A A, Hurwitz, J, Ziskin, J, Villasenor, J P, Medema, W W, Overwijk, N P, Restifo, C J, Melief, R, Offringa, J P, Allison

Publikováno v: The Journal of Experimental Medicine

We have previously shown that small B16 melanomas can be successfully treated using a combination of anti-cytotoxic T lymphocyte antigen (CTLA)-4 monoclonal antibody with a granulocyte/macrophage colony-stimulating factor (GM-CSF) producing irradiate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ee924dc178288b2ef8ce824b6d57eb64
https://pubmed.ncbi.nlm.nih.gov/11514604

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Self-tolerance to the murine homologue of a tyrosinase-derived melanoma antigen: implications for tumor immunotherapy

Autor: T A, Colella, T N, Bullock, L B, Russell, D W, Mullins, W W, Overwijk, C J, Luckey, R A, Pierce, N P, Restifo, V H, Engelhard

Publikováno v: The Journal of Experimental Medicine

The human tyrosinase-derived peptide YMDGTMSQV is presented on the surface of human histocompatibility leukocyte antigen (HLA)-A*0201(+) melanomas and has been suggested to be a tumor antigen despite the fact that tyrosinase is also expressed in mela

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8696101cca7cb68e3a8da1390b69a16e
https://pubmed.ncbi.nlm.nih.gov/10748239

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Enhancement of tumor-specific immune response with plasmid DNA replicon vectors

Autor: W W, Leitner, H, Ying, D A, Driver, T W, Dubensky, N P, Restifo

Publikováno v: Cancer research. 60(1)

To enhance the immunogenicity of nucleic acid vaccines, we used plasmid DNA vectors that contained replicons derived from the prototype alphavirus, Sindbis, and another alphavirus, Semliki Forest virus. When transfected into cells or injected directl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ca0c26c8912a390f40748feb4fea4329
https://pubmed.ncbi.nlm.nih.gov/10646851

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Impact of cytokine administration on the generation of antitumor reactivity in patients with metastatic melanoma receiving a peptide vaccine

Autor: S A, Rosenberg, J C, Yang, D J, Schwartzentruber, P, Hwu, F M, Marincola, S L, Topalian, N P, Restifo, M, Sznol, S L, Schwarz, P J, Spiess, J R, Wunderlich, C A, Seipp, J H, Einhorn, L, Rogers-Freezer, D E, White

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 163(3)

Patients with metastatic melanoma were immunized with an immunodominant peptide derived from the gp100 melanoma-melanocyte differentiation Ag that was modified to increase binding to HLA-A+0201. A total of 10 of 11 patients who received the g209–2M

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ccc3d6efdf8269c5435a2713fcf72f31
https://pubmed.ncbi.nlm.nih.gov/10415076

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Recombinant virus vaccination against 'self' antigens using anchor-fixed immunogens

Autor: K R, Irvine, M R, Parkhurst, E P, Shulman, J P, Tupesis, M, Custer, C E, Touloukian, P F, Robbins, A G, Yafal, P, Greenhalgh, R P, Sutmuller, R, Offringa, S A, Rosenberg, N P, Restifo

Publikováno v: Cancer research. 59(11)

To study the induction of anti-"self" CD8+ T-cell reactivity against the tumor antigen gp100, we used a mouse transgenic for a chimeric HLA-A*0201/H-2 Kb molecule (A2/Kb). We immunized the mice with a recombinant vaccinia virus encoding a form of gp1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ddca7a821209667985ee7f70ee002ce8
https://pubmed.ncbi.nlm.nih.gov/10363968

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Fas-mediated suicide of tumor-reactive T cells following activation by specific tumor: selective rescue by caspase inhibition

Autor: T Z, Zaks, D B, Chappell, S A, Rosenberg, N P, Restifo

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 162(6)

CD8+ T lymphocytes that specifically recognize tumor cells can be isolated and expanded ex vivo. While the lytic properties of these cells have been well described, their fate upon encounter with cognate tumor is not known. We performed reverse 51Cr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f2b92c331d1978337e4bec86f8cd4df7
https://pubmed.ncbi.nlm.nih.gov/10092779

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CD40 ligand/trimer DNA enhances both humoral and cellular immune responses and induces protective immunity to infectious and tumor challenge

Autor: S, Gurunathan, K R, Irvine, C Y, Wu, J I, Cohen, E, Thomas, C, Prussin, N P, Restifo, R A, Seder

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 161(9)

CD40/CD40 ligand interactions have a central role in the induction of both humoral and cellular immunity. In this study, we examined whether a plasmid expressing CD40 ligand/trimer (CD40LT) could enhance immune responses in vivo. BALB/c mice were inj

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e2c378fe2b19f2e117430eb6874951a6
https://pubmed.ncbi.nlm.nih.gov/9794383

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