Zobrazeno 1 - 10
of 26
pro vyhledávání: '"N P, Gerard"'
Publikováno v:
The Journal of Immunology. 158:3561-3564
Inspection of the intron splice junction of the mouse chemokine receptor fusin/CXC chemokine receptor R-4 (CXCR-4) revealed a potential in-frame alternative splice site in the region encoding the N-terminal ectodomain of the receptor. Both predicted
Publikováno v:
The Journal of Immunology. 156:786-792
The hemolytically inactive complement component complex C5b67, designated iC5b67, can signal human polymorphonuclear leukocytes (PMN) both as a pertussis toxin-inhibitable agonist for chemotaxis and as an antagonist for C5a- and FMLP-stimulated chemo
Autor:
N P Gerard, C Gerard
Publikováno v:
The Journal of Immunology. 152:793-800
A human neutrophil platelet-activating factor (PAF) receptor expressed in transfected cells was utilized to study receptor-dependent interactions with the ligand. This receptor displays ligand-binding properties comparable with those observed with na
Publikováno v:
The Journal of Immunology. 149:2600-2606
The mouse C5a receptor gene was isolated using the human C5a receptor cDNA probe recently described (Gerard, N. P., and C. Gerard. 1991. Nature 349:614). By analogy with the human gene, the mouse homolog contains two exons with the 5' untranslated re
Publikováno v:
European journal of immunology. 29(11)
The gene encoding the murine homologue of human CXCR3 exists in a single copy consisting of two exons with an intron interrupting the coding sequence between nucleotides 10 and 11. The deduced amino acid sequence is 86% identical to the predicted hum
Autor:
I, Sabroe, D M, Conroy, N P, Gerard, Y, Li, P D, Collins, T W, Post, P J, Jose, T J, Williams, C J, Gerard, P D, Ponath
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 161(11)
Certain C-C chemokines, signaling via the eotaxin receptor C-C chemokine receptor-3 (CCR3), are thought to be central mediators of eosinophil accumulation in allergic inflammation. To investigate the role of CCR3 in vivo, we cloned the guinea pig eot
Publikováno v:
Advances in experimental medicine and biology. 416
Streptococcus pneumoniae can produce asymptomatic colonization or aggressive sepsis. We sought to differentiate the molecular mechanisms of these disparate courses. Cytokine or thrombin activation of human vascular endothelial cells and type II pneum
Publikováno v:
The Journal of biological chemistry. 270(42)
Streptococcus pneumoniae has been shown to utilize the platelet activating factor receptor for binding and invasion of host cells (Cundell, D. R., Gerard, N. P., Gerard, C., Idanpaan-Heikkila, I., and Tuomanen, E. I. (1995) Nature, in press). Because
Publikováno v:
The Journal of biological chemistry. 270(30)
The C5a anaphylatoxin ligand-receptor interaction on polymorphonuclear granulocytes stimulates chemotaxis, degranulation, and the oxidative burst. The receptor is a member of the large G-protein-coupled family. The ligand is a cationic peptide of 72
Autor:
C R, Bozic, L F, Kolakowski, N P, Gerard, C, Garcia-Rodriguez, C, von Uexkull-Guldenband, M J, Conklyn, R, Breslow, H J, Showell, C, Gerard
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 154(11)
KC, the product of an immediate early gene induced in mouse fibroblasts by platelet-derived growth factor, was expressed in Escherichia coli by using a maltose binding protein vector and biochemically characterized as a ligand for both murine and hum