Zobrazeno 1 - 10
of 1 654
pro vyhledávání: '"N Olson"'
A molecular pathway for cancer cachexia-induced muscle atrophy revealed at single-nucleus resolution
Autor:
Yichi Zhang, Matthieu Dos Santos, Huocong Huang, Kenian Chen, Puneeth Iyengar, Rodney Infante, Patricio M. Polanco, Rolf A. Brekken, Chunyu Cai, Ambar Caijgas, Karla Cano Hernandez, Lin Xu, Rhonda Bassel-Duby, Ning Liu, Eric N. Olson
Publikováno v:
Cell Reports, Vol 43, Iss 8, Pp 114587- (2024)
Summary: Cancer cachexia is a prevalent and often fatal wasting condition that cannot be fully reversed with nutritional interventions. Muscle atrophy is a central component of the syndrome, but the mechanisms whereby cancer leads to skeletal muscle
Externí odkaz:
https://doaj.org/article/178060e694dc445f9c9795570d7dc38d
Autor:
MJ Alfa, GKM Harding, AR Ronald, RB Light, N MacFarlane, N Olson, P DeGagne, K Kasdorf, A Simor, KS MacDonald, L Louie
Publikováno v:
Canadian Journal of Infectious Diseases, Vol 10, Iss 4, Pp 287-294 (1999)
OBJECTIVE: To monitor prospectively patients with Clostridium difficile-associated diarrhea (CAD) in a six hundred bed tertiary care hospital to determine which factors influenced the recurrence of the diarrhea.
Externí odkaz:
https://doaj.org/article/f3c21cdc5d5d4a84836e1a8c75348c32
Autor:
Matthieu Dos Santos, Akansha M. Shah, Yichi Zhang, Svetlana Bezprozvannaya, Kenian Chen, Lin Xu, Weichun Lin, John R. McAnally, Rhonda Bassel-Duby, Ning Liu, Eric N. Olson
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Skeletal muscle fibers express distinct gene programs during development and maturation, but the underlying gene regulatory networks that confer stage-specific myofiber properties remain unknown. To decipher these distinctive gene programs a
Externí odkaz:
https://doaj.org/article/be1965dd27c140d994a010d7e4345d38
Autor:
Molly Smullen, Meagan N. Olson, Liam F. Murray, Madhusoodhanan Suresh, Guang Yan, Pepper Dawes, Nathaniel J. Barton, Jivanna N. Mason, Yucheng Zhang, Aria A. Fernandez-Fontaine, George M. Church, Diego Mastroeni, Qi Wang, Elaine T. Lim, Yingleong Chan, Benjamin Readhead
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract Mitochondrial (MT) dysfunction has been associated with several neurodegenerative diseases including Alzheimer’s disease (AD). While MT-copy number differences have been implicated in AD, the effect of MT heteroplasmy on AD has not been we
Externí odkaz:
https://doaj.org/article/7f133d69551245a7bf77cd609ed77e08
Autor:
Andreas C. Chai, Francesco Chemello, Hui Li, Takahiko Nishiyama, Kenian Chen, Yu Zhang, Efraín Sánchez-Ortiz, Adeeb Alomar, Lin Xu, Ning Liu, Rhonda Bassel-Duby, Eric N. Olson
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 32, Iss , Pp 522-535 (2023)
Duchenne muscular dystrophy (DMD) is a fatal X-linked recessive disease of progressive muscle weakness and wasting caused by the absence of dystrophin protein. Current gene therapy approaches using antisense oligonucleotides require lifelong dosing a
Externí odkaz:
https://doaj.org/article/ceeab5a0e2ca4e8485c28a7ea3202410
Autor:
Mina Shahriyari, Md Rezaul Islam, Sadman M. Sakib, Malte Rinn, Anastasia Rika, Dennis Krüger, Lalit Kaurani, Verena Gisa, Mandy Winterhoff, Harithaa Anandakumar, Orr Shomroni, Matthias Schmidt, Gabriela Salinas, Andreas Unger, Wolfgang A. Linke, Jana Zschüntzsch, Jens Schmidt, Rhonda Bassel‐Duby, Eric N. Olson, André Fischer, Wolfram‐Hubertus Zimmermann, Malte Tiburcy
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 13, Iss 6, Pp 3106-3121 (2022)
Abstract Background Human pluripotent stem cell‐derived muscle models show great potential for translational research. Here, we describe developmentally inspired methods for the derivation of skeletal muscle cells and their utility in skeletal musc
Externí odkaz:
https://doaj.org/article/1634c6c809c344e3adcd3f61bb3b0fea
Autor:
Yichi Zhang, Andres Ramirez-Martinez, Kenian Chen, John R. McAnally, Chunyu Cai, Mateusz Z. Durbacz, Francesco Chemello, Zhaoning Wang, Lin Xu, Rhonda Bassel-Duby, Ning Liu, Eric N. Olson
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 13 (2023)
Mutations in genes encoding nuclear envelope proteins lead to diseases known as nuclear envelopathies, characterized by skeletal muscle and heart abnormalities, such as Emery-Dreifuss muscular dystrophy (EDMD). The tissue-specific role of the nuclear
Externí odkaz:
https://doaj.org/article/089e6d82f4e743d5a199cbe608f89e95
Autor:
Yu Zhang, Hui Li, Takahiko Nishiyama, John R. McAnally, Efrain Sanchez-Ortiz, Jian Huang, Pradeep P.A. Mammen, Rhonda Bassel-Duby, Eric N. Olson
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 29, Iss , Pp 525-537 (2022)
Duchenne muscular dystrophy (DMD) is a lethal neuromuscular disease caused by mutations in the X-linked dystrophin (DMD) gene. Exon deletions flanking exon 51, which disrupt the dystrophin open reading frame (ORF), represent one of the most common ty
Externí odkaz:
https://doaj.org/article/8f85bc1de0294f5dae39c44e2af2513a
Autor:
Dileep R. Karri, Yu Zhang, Francesco Chemello, Yi-Li Min, Jian Huang, Jiwoong Kim, Pradeep P.A. Mammen, Lin Xu, Ning Liu, Rhonda Bassel-Duby, Eric N. Olson
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 28, Iss , Pp 154-167 (2022)
Duchenne muscular dystrophy (DMD) is a lethal muscle disease caused by mutations in the dystrophin gene. CRISPR/Cas9 genome editing has been used to correct DMD mutations in animal models at young ages. However, the longevity and durability of CRISPR
Externí odkaz:
https://doaj.org/article/b43ce09cc0a3454181205c248f318e1a
Autor:
Xurde M. Caravia, Andres Ramirez-Martinez, Peiheng Gan, Feng Wang, John R. McAnally, Lin Xu, Rhonda Bassel-Duby, Ning Liu, Eric N. Olson
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 22 (2022)
Mutations in nuclear envelope proteins (NEPs) cause devastating genetic diseases, known as envelopathies, that primarily affect the heart and skeletal muscle. A mutation in the NEP LEM domain–containing protein 2 (LEMD2) causes severe cardiomyopath
Externí odkaz:
https://doaj.org/article/fbc0f2db436f472f8bc0e6a56d395731