Zobrazeno 1 - 10
of 23
pro vyhledávání: '"N Nora Yang"'
Publikováno v:
PLoS ONE, Vol 13, Iss 6, p e0198893 (2018)
BACKGROUND AND OBJECTIVE:Gait analysis is valuable for studying neuromuscular and skeletal diseases. Wearable motion sensors or inertial measurement units (IMUs) have become common for human gait analysis. Canines are important large animal models fo
Externí odkaz:
https://doaj.org/article/b6d506028dba4de6841706b0fe11b119
Autor:
Chady H. Hakim, Sandeep R. P. Kumar, Dennis O. Pérez-López, Nalinda B. Wasala, Dong Zhang, Yongping Yue, James Teixeira, Xiufang Pan, Keqing Zhang, Emily D. Million, Christopher E. Nelson, Samantha Metzger, Jin Han, Jacqueline A. Louderman, Florian Schmidt, Feng Feng, Dirk Grimm, Bruce F. Smith, Gang Yao, N. Nora Yang, Charles A. Gersbach, Shi-jie Chen, Roland W. Herzog, Dongsheng Duan
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
The Cas9-specific T cell response has been speculated to impair CRISPR therapy. Here, the authors show that local and systemic AAV CRISPR therapy induces cytotoxic killing and eliminates rescued dystrophin in canine models of Duchenne muscular dystro
Externí odkaz:
https://doaj.org/article/fa789cec57864e868cf64db8cae359c5
Autor:
Chady H. Hakim, Nathalie Clément, Lakmini P. Wasala, Hsiao T. Yang, Yongping Yue, Keqing Zhang, Kasun Kodippili, Laura Adamson-Small, Xiufang Pan, Joel S. Schneider, N. Nora Yang, Jeffrey S. Chamberlain, Barry J. Byrne, Dongsheng Duan
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 18, Iss , Pp 664-678 (2020)
Vector production scale-up is a major barrier in systemic adeno-associated virus (AAV) gene therapy. Many scalable manufacturing methods have been developed. However, the potency of the vectors generated by these methods has rarely been compared with
Externí odkaz:
https://doaj.org/article/c9a8a753dbc949b9af502c5c8edc3335
Autor:
Chady H. Hakim, Hsiao T. Yang, Matthew J. Burke, James Teixeira, Gregory J. Jenkins, N. Nora Yang, Gang Yao, Dongsheng Duan
Publikováno v:
Disease Models & Mechanisms, Vol 14, Iss 12 (2021)
Aged dystrophin-null canines are excellent models for studying experimental therapies for Duchenne muscular dystrophy, a lethal muscle disease caused by dystrophin deficiency. To establish the baseline, we studied the extensor carpi ulnaris (ECU) mus
Externí odkaz:
https://doaj.org/article/f1538e91b7024c3397c00238eaa469ae
Autor:
Bruce F. Smith, Scott D. Fitzgerald, Chady H. Hakim, Dongsheng Duan, Scott W. Korte, Jessica S. Fortin, N. Nora Yang, Gayle C. Johnson
Publikováno v:
Veterinary Medicine and Science
Veterinary Medicine and Science, Vol 7, Iss 3, Pp 654-659 (2021)
Veterinary Medicine and Science, Vol 7, Iss 3, Pp 654-659 (2021)
The University of Missouri (MU) has established a colony of dystrophin‐deficient dogs with a mixed breed background to mirror the variable pathologic effects of dystrophinopathies between persons of a given kindred to further the understanding of t
Autor:
Dongsheng Duan, Yongping Yue, Lakmini P. Wasala, Xiufang Pan, Jeffrey S. Chamberlain, N. Nora Yang, Chady H. Hakim, Nathalie Clement, Joel S. Schneider, Keqing Zhang, Barry J. Byrne, Kasun Kodippili, Laura Adamson-Small, Hsiao T. Yang
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 18, Iss, Pp 664-678 (2020)
Molecular Therapy. Methods & Clinical Development
Molecular Therapy. Methods & Clinical Development
Vector production scale-up is a major barrier in systemic adeno-associated virus (AAV) gene therapy. Many scalable manufacturing methods have been developed. However, the potency of the vectors generated by these methods has rarely been compared with
Publikováno v:
Hum Gene Ther
Clustered regularly interspaced short palindromic repeats (CRISPR) editing is being considered as a potential gene repair therapy to treat Duchenne muscular dystrophy, a dystrophin-deficient lethal muscle disease affecting all muscles in the body. A
Autor:
Scott W. Korte, N. Nora Yang, Bruce F. Smith, Scott D. Fitzgerald, Gayle C. Johnson, Chady H. Hakim, Dongsheng Duan, Jessica S. Fortin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::40a901fe86d5d6df6282a999d8060cbe
https://doi.org/10.1002/vms3.433/v2/response1
https://doi.org/10.1002/vms3.433/v2/response1
Autor:
Marine Theret, Pascal Bernatchez, Constadina Panagiotopoulos, Chady H. Hakim, Fabio M.V. Rossi, Volker Straub, Kathryn Selby, Dan Cox, Gordon A. Francis, N. Nora Yang, Zoe White, Dongsheng Duan
Publikováno v:
J Clin Lipidol
Background Duchenne muscular dystrophy (DMD) and Becker muscular dystrophy (BMD) are allelic X-linked recessive muscle diseases caused by mutations in the DMD gene, with DMD being the more severe form. We have recently shown that increased plasma low
Autor:
Chady H. Hakim, Xiufang Pan, N. Nora Yang, Ronald L. Terjung, Dongsheng Duan, M. H. Laughlin, Kasun Kodippili, Hsiao T. Yang
Publikováno v:
The Journal of Physiology. 596:5199-5216
Key points We developed a novel method to study sympatholysis in dogs. We showed abolishment of sarcolemmal nNOS, and reduction of total nNOS and total eNOS in the canine Duchenne muscular dystrophy (DMD) model. We showed sympatholysis in dogs involv