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[Dimeric bisberzimidazoles: cytotoxicity and effects on DNA methylation in normal and cancer human cells]

Autor: M V, Dariĭ, A R, Rakhimova, V N, Tashlitskiĭ, S V, Kostiuk, N N, Veĭko, A A, Ivanov, A L, Zhuze, E S, Gromova

Publikováno v: Molekuliarnaia biologiia. 47(2)

Cancer cells are characterized by the hypermethylation of promoter regions of tumor suppressor genes. DNA methyltransferase inhibitors cause re-activation of these genes that allows considering DNA methyltransferases as targets for anticancer therapy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8136928673834b2087ea94ef1efe2791
https://pubmed.ncbi.nlm.nih.gov/23808164

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[DNA-signaling pathway mediating development of a radiation-induced bystander effect in human cells]

Autor: A V, Ermakov, M S, Kon'kova, S V, Kostiuk, N N, Veĭko

Publikováno v: Radiatsionnaia biologiia, radioecologiia. 51(6)

Low doses of ionizing radiation induce the adaptive effect (AE) development in human cells which is followed by a number of cell responses. These responses can be transmitted from irradiated cells to non-irradiated ones (bystander effect, BE). The ma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bc50d587725c8c723e3a142ff971e66a
https://pubmed.ncbi.nlm.nih.gov/22384714

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[Delayed appearance of hypertension in spontaneously hypertensive rat (SHR) injected with CpG-rich DNA early in ontogenesis]

Autor: Postnov AIu, Neverova Me, I. L. Konorova, Fidelina Ov, Elizaveta S. Ershova, Mkrtumova Na, Marina S. Konkova, N N Veĭko

Publikováno v: Europe PubMed Central

In this study we have investigated properties of blood serum extracellular DNA (cell-free DNA) from patients with essential arterial hypertension (AH). Cell-free DNA concentration was not changed in the control AH group compared to norma (healthy don

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ad2cfc9656135568e50a1831c88e585
https://pubmed.ncbi.nlm.nih.gov/21395071

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[Ribosomal genes in the human genome: identification of four fractions, their organization in the nucleolus and metaphase chromosomes]

Autor: N A, Liapunova, N N, Veĭko

Publikováno v: Genetika. 46(9)

Completion of human genome reading stimulated intense studies in the field of functional genomics and characterization of individual genomes. Of considerable importance is the study of the complex of multicopy ribosomal genes (RGs), but its thorough

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fdaca87ecb1b0eccde42b783004de948
https://pubmed.ncbi.nlm.nih.gov/21061619

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[Bystander effect development in human mesenchymal stem cells after exposure to adaptive dose of X-radiation]

Autor: A V, Ermakov, M S, Kon'kova, S V, Kostiuk, T D, Smirnova, L V, Kameneva, R V, Veĭko, I Iu, Kubasova, L N, Liubchenko, N N, Veĭko

Publikováno v: Radiatsionnaia biologiia, radioecologiia. 50(1)

Transposition and mutual approaching of pericentromeric loci 1q12 of homological chromosomes from the nuclear membrane towards the nuclear centre as well as activation of the chromosomal nucleolus-forming regions (NFR) are observed in human mesenchym

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1c987bd0ef0ae09f3c0052e74a886e9a
https://pubmed.ncbi.nlm.nih.gov/20297680

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[CpG-DNA inhibits cell reactions accompanied with the development of the adaptive response in human lymphocytes after low-dose X-ray exposure]

Autor: A V, Ermakov, M S, Kon'kova, S V, Kostiuk, E A, Kalashnikova, S N, Kokarovtseva, N A, Egolina, N N, Veĭko

Publikováno v: Radiatsionnaia biologiia, radioecologiia. 49(1)

The lymphocytes of peripheral blood of healthy donors were influenced by X-ray radiation (10 cGy) or a fragments of the transcribed region of rDNA (TRrDNA) transmitted to the incubation medium of non-irradiated cells. Both factors induced transpositi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8bb3af912baaa6798b626d5ac6b40dba
https://pubmed.ncbi.nlm.nih.gov/19368319

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[The changing of cell-free DNA properties of peripheral blood and TCR-mutant cell frequency in individuals exposed to ionizing radiation]

Autor: S V, Kostiuk, I A, Zamulaeva, R K, Agapova, A V, Ermakov, A S, Saenko, N V, Orlova, S G, Smirnova, N N, Veĭko, D M, Spitkovskiĭ

Publikováno v: Radiatsionnaia biologiia, radioecologiia. 48(1)

Some properties of the cell-free DNA (cfDNA) of peripheral blood plasma were assessed in 153 employees of atomic industry enterprises. The contents of ribosomal repeat (rDNA) and its concentration in plasma increased in cfDNA of the group of persons

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1b4fd98f6a5b8c03c7a0c7cb434a9347
https://pubmed.ncbi.nlm.nih.gov/18666576

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[Stress signaling between human lymphocytes after induction of bystander effect by exposure to ionizing radiation in adaptive doses]

Autor: A V, Ermakov, S V, Kostiuk, N A, Egolina, E A, Kalashnikova, S N, Kokarovtseva, E M, Malinovskaia, N N, Veĭko

Publikováno v: Radiatsionnaia biologiia, radioecologiia. 47(6)

We previously reported that the consequence of human lymphocytes irradiation by the adaptive doses (X-rays, 10 cGy) was a transposition of the homologous chromosome loci in the cell nucleus (FISH method); this phenomenon was mediated by the increase

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bab3f0f4a0b39fe8a5f3b92c168130ed
https://pubmed.ncbi.nlm.nih.gov/18380323

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[Ribosomal genes in inbred mouse strains: interstrain and intrastrain variations of copy number and extent of methylation]

Autor: N N, Veĭko, N O, Shubaeva, A M, Malashenko, T B, Beskova, R K, Agapova, N A, Liapunova

Publikováno v: Genetika. 43(9)

Quantitative dot hybridization was used to estimate the rDNA copy number in brain tissues of five inbred mouse strains (AKR/JY, NZB/B1OrlY, CBA/CaLacY, 101/HY, and 129/JY), which were obtained from the collection of the Research Center of Biomedical

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::80f2a198bfb34487ee4f8c4ed16c30e3
https://pubmed.ncbi.nlm.nih.gov/17990521

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[The DNA fragments obtained from the culture media exposed to adaptive doses of the ionizing radiation as factors of stress signaling between lymphocytes and bystander cells]

Autor: A V, Ermakov, S V, Kostiuk, N A, Egolina, E M, Malinovskaia, N N, Veĭko, D M, Spitkovskiĭ

Publikováno v: Radiatsionnaia biologiia, radioecologiia. 47(2)

At the initial stages of an adaptive response the transposition of the homologous chromosome loci from the peripheral parts of the nucleus and their approach happens. It is necessary for the repair of DNA double strand breaks in the process of the ho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e2c9f3a9d9909172e20fa44328ebbfed
https://pubmed.ncbi.nlm.nih.gov/17571721

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