Výsledky vyhledávání - "N N Jiménez-Vargas"

A277 A NOVEL PH-SENSITIVE Μ-OPIOID RECEPTOR AGONIST THAT DOES NOT INDUCE TOLERANCE IN A COLITIS MOUSE MODEL

Autor: C E Degro, N N Jiménez-Vargas, H M Schincariol, Q K Tsang, M Guzman-Rodriguez, A E Lomax, D E Reed, C Stein, N W Bunnett, S J Vanner

Publikováno v: Journal of the Canadian Association of Gastroenterology. 6:90-91

Background Adequate pain control in inflammatory bowel disease (IBD) can require opioids due to their high analgesic potency. The long-term use of opioids, however, is limited by the development of tolerance. This leads to reduced analgesic efficacy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ec0dcbdd5db36f089fdf65a71874a203
https://doi.org/10.1093/jcag/gwac036.277

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A53 A NOVEL PH-SENSITIVE OPIOID ANALOGUE PROVIDES SUSTAINED ANALGESIA DURING COLONIC INFLAMMATION AND LACKS COMMON SIDE EFFECTS

Autor: C E Degro, N N Jiménez-Vargas, Q K Tsang, Y Yu, C Stein, N W Bunnett, A E Lomax, D E Reed, S Vanner

Publikováno v: Journal of the Canadian Association of Gastroenterology. 5:61-62

Background Opioids provide effective pain relief during flares of inflammatory bowel disease but are limited by serious side effects. We showed that acute administration of a novel pH-sensitive opioid agonist, NFEPP, had potent analgesic effects in i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::56d63ccf9ff88788ff10d5d303119257
https://doi.org/10.1093/jcag/gwab049.052

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A242 STOOL FROM IBS-D PATIENT WITH A HISTORY OF A DYSBIOTIC AND NON-DYSBIOTIC ONSET MODULATE NEURONAL EXCITABILITY VIA DIFFERENT MECHANISMS

Autor: N N Jiménez-Vargas, M Guzman Rodriguez, Y Yu, E Neary, A E Lomax, D E Reed, S Vanner

Publikováno v: Journal of the Canadian Association of Gastroenterology. 5:134-135

Background We have shown that Irritable Bowel Syndrome diarrhea-predominant (IBS-D) patients with a history of a dysbiotic-like onset have distinct stool metabolomic profiles versus those with a non-dysbiotic-like onset. IBS stool supernatants can se

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::91106838d1d56c9aad3cb38afd8433a0
https://doi.org/10.1093/jcag/gwab049.241

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A243 HISTAMINE H1-RECEPTOR ANTAGONISTS SUPPRESS THE HYPEREXCITABILITY OF NOCICEPTIVE NEURONS EXPOSED TO IBS-C PATIENT STOOL SUPERNATANTS

Autor: E Neary, N N Jiménez-Vargas, A E Lomax, D E Reed, S Vanner

Publikováno v: Journal of the Canadian Association of Gastroenterology. 5:135-136

Background Abdominal pain is the primary cause of morbidity in many chronic GI disorders such as IBS, but the molecular mechanisms contributing to pain signaling are unclear. Stool supernatants from patients with diarrhea-predominant IBS increase the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e96527b2a4b003aea51f09ad2539f5bd
https://doi.org/10.1093/jcag/gwab049.242

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Inhibition of extracellular nucleotides hydrolysis intensifies the allergic bronchospasm. A novel protective role of ectonucleotidases

Autor: N. N. Jiménez-Vargas, Mario H. Vargas, M. Flores-García, Luis M. Montaño, Verónica Díaz-Hernández, Edgar Flores-Soto, Carlos Barajas-López, D. C. Rebollar-Ayala, Jaime Chávez, José E. Cruz-Valderrama

Publikováno v: Allergy. 68(4)

Background Nucleotides released to the extracellular space stimulate purinergic receptors, and their effects are modulated by ectonucleotidases. The role of ATP in the allergic bronchospasm has been scantly studied. Methods We used several techniques

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d146b86326a2f1b7aab21da0d04c524
https://pubmed.ncbi.nlm.nih.gov/23414231

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