Výsledky vyhledávání - "N N, Khodarev"

An inducible lymphocyte nuclear Ca2+/Mg(2+)-dependent endonuclease associated with apoptosis

Autor: N N Khodarev, J D Ashwell

Publikováno v: The Journal of Immunology. 156:922-931

Apoptotic cell death is typically accompanied by internucleosomal chromatin fragmentation. Although a number of candidate enzymes have been proposed, there is as yet no direct evidence for the involvement of any particular endonuclease in this proces

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6570e71eb3413de024b9204e7fb6e205
https://doi.org/10.4049/jimmunol.156.3.922

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Changes in Ca,Mg-dependent DNA endonuclease in isolated human lymphocyte nuclei in lymphoproliferative diseases

Autor: N. N. Khodarev, T. I. Tkacheva, S. S. Kirzon, I I Votrin

Publikováno v: Bulletin of Experimental Biology and Medicine. 109:720-723

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3346e627950d66145e90298435c283f0
https://doi.org/10.1007/bf00841426

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LINE L1 retrotransposable element is targeted during the initial stages of apoptotic DNA fragmentation

Autor: N N, Khodarev, T, Bennett, N, Shearing, I, Sokolova, J, Koudelik, S, Walter, M, Villalobos, A T, Vaughan

Publikováno v: Journal of cellular biochemistry. 79(3)

Using a directional cloning strategy, DNA sequence information was obtained corresponding to the site of early radiation-induced apoptotic DNA fragmentation within the human lymphoblastoid cell line TK6. Data were obtained from 88 distinct clones com

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::28462b371575d888b2a9f7fed346a067
https://pubmed.ncbi.nlm.nih.gov/10972985

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Association between DNA cleavage during apoptosis and regions of chromatin replication

Autor: N N, Khodarev, I A, Sokolova, A T, Vaughan

Publikováno v: Journal of cellular biochemistry. 70(4)

We have addressed the association between the site of DNA cleavage during apoptosis and DNA replication. DNA double strand breaks were introduced into chromatin containing pulse labeled nascent DNA by the induction of apoptosis or autocleavage of iso

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::da951991910a4dccf3ec53cc92c4398d
https://pubmed.ncbi.nlm.nih.gov/9712157

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Mechanisms of induction of apoptotic DNA fragmentation

Autor: N N, Khodarev, I A, Sokolova, A T, Vaughan

Publikováno v: International journal of radiation biology. 73(5)

Despite its common use as an indicator of apoptosis, little is known about the mechanisms controlling apoptotic DNA fragmentation in irradiated cells. This review discusses the pathways of chromatin fragmentation, and the role of both nucleases and c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::13bae2b6bdec351a4fa32a93204dc7f9
https://pubmed.ncbi.nlm.nih.gov/9652802

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Multiple forms of endonuclease activity linked with radiation induced apoptosis in C4-1 cervical carcinoma cells

Autor: E, Krueger, I, Sokolova, M, Kamradt, N N, Khodarev, A T, Vaughan

Publikováno v: Anticancer research. 18(2A)

Irradiation of C4-1 cervical carcinoma cells induced apoptosis, as determined by their morphology and the presence of oligonucleosomal DNA fragmentation, with the formation of 5'- P and 3'-OH termini. Extracts of nuclear proteins from both control an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::15800bb946ba7ff155f63604d3d6e990
https://pubmed.ncbi.nlm.nih.gov/9615751

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[Comparative characteristics of some parameters of the cell nucleus in the series myeloma-hybridoma-lymphocyte]

Autor: I A, Sokolova, A Iu, Volgin, T D, Smirnova, I P, Lupga, N N, Khodarev, S S, Shishkin

Publikováno v: Biokhimiia (Moscow, Russia). 58(3)

A comparative study of several parameters of the cell nuclei of hybridoma MLC-1c and its parent cells--myeloma X-63.Ag8.653 and spleen lymphocytes of Balb/c mice, has been carried out. The results of cytogenetic studies suggest that although the hybr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::24cdc885e2486bc509f21c3511fdbb5c
https://pubmed.ncbi.nlm.nih.gov/8485224

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[Changes in Ca, Mg-dependent endonuclease of DNA in isolated nuclei of human lymphocytes in lymphoproliferative diseases]

Autor: T I, Tkacheva, S S, Kirzon, N N, Khodarev, I I, Botrin

Publikováno v: Biulleten' eksperimental'noi biologii i meditsiny. 109(6)

Ca, Mg-dependent endonuclease is one of the main DNAses of lymphocyte chromatin. It's activity is known to increase in the immune response and to decrease in spontaneous and experimental CLL. These observations became a basis for analysis of possible

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bb5fcbaea1d237942f952b1bcb4df68f
https://pubmed.ncbi.nlm.nih.gov/2397289

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