Synthesis and Cytotoxicity of Epiandrosterone Hydrazones

Autor: Jean Legault, N. Sh. Nadaraia, N. N. Barbakadze, André Pichette, Vakhtang Mshvildadze, B. Sylla

Publikováno v: Chemistry of Natural Compounds. 56:274-277

Two series of hydrazones were synthesized from 3β-hydroxy- and 3β-(1-adamantoate)-5α-androstan-17- one, respectively, to study the structure–activity relationship. Cytotoxicity studies showed that 5α-androstan- 3β-ol-17-one m-nitrobenzoylhydra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::97921705dbcca0e2cdfa520dd880fd9d
https://doi.org/10.1007/s10600-020-03005-2

Synthesis and Biological Activity of Steroidal Tigogenin Hydrazones and Pyrazolines

Autor: N. N. Barbakadze, B. Sylla, M. L. Kakhabrishvili, N. Sh. Nadaraia, André Pichette, Vakhtang Mshvildadze, Jean Legault

Publikováno v: Chemistry of Natural Compounds. 54:926-929

Steroidal hydrazones and pyrazolines were synthesized via condensation of a series of 5α-steroidal ketones with several hydrazines. Their cytotoxic activity against cancer cultures (A549 lung cancer, DLD-1 colorectal cancer, and WS1 normal skin fibr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::37998f5a5d4680e22224389f5e72f26d
https://doi.org/10.1007/s10600-018-2514-9

Synthesis and Antiviral Activity of Several N-Containing 5α-STEROIDS

Autor: N. Sh. Nadaraia, André Pichette, N. N. Barbakadze, M. L. Kakhabrishvili, B. Sylla, E. O. Onashvili

Publikováno v: Chemistry of Natural Compounds

A study of the antiviral activity of several new hydrazones and amines and amides of 5α-steroids that were synthesized by us earlier found highly and moderately active compounds. The structures of the synthesized compounds were proven using IR, PMR,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6eb26e19f6ed2f67337b470b78068f74
https://doi.org/10.1007/s10600-016-1795-0

Synthesis of Several 5α-Androstano[17,16-d]Pyrazolines from Tigogenin

Autor: N. N. Barbakadze, M. Z. Getia, E. O. Onashvili, M. I. Sikharulidze, André Pichette, M. L. Kakhabrishvili, N. Sh. Nadaraia, U. S. Makhmudov

Publikováno v: Chemistry of Natural Compounds.

New androstanopyrazolines and hydrazones were synthesized via acid-catalyzed condensation of the tigogenin transformation product 5α-pregnenolone with several hydrazines. Their structures were proved using IR and NMR spectroscopy and mass spectromet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6a57fded153ad489594c9e82987f6fff
https://doi.org/10.1007/s10600-014-1151-1

Steroidal hydrazones as antimicrobial agents: biological evaluation and molecular docking studies.

Autor: Merlani M; TSMU I, Kutateladze Institute of Pharmacochemistry, Tbilisi, Georgia., Nadaraia N; TSMU I, Kutateladze Institute of Pharmacochemistry, Tbilisi, Georgia., Barbakadze N; TSMU I, Kutateladze Institute of Pharmacochemistry, Tbilisi, Georgia., Amiranashvili L; TSMU I, Kutateladze Institute of Pharmacochemistry, Tbilisi, Georgia., Kakhabrishvili M; TSMU I, Kutateladze Institute of Pharmacochemistry, Tbilisi, Georgia., Petrou A; School of Pharmacy, Aristotle University of Thessaloniki, Thessaloniki, Greece., Carević T; Department of Plant Physiology, Institute for Biological Research 'Siniša Stanković' - National Institute of Republic of Serbia, University of Belgrade, Belgrade, Serbia., Glamočlija J; Department of Plant Physiology, Institute for Biological Research 'Siniša Stanković' - National Institute of Republic of Serbia, University of Belgrade, Belgrade, Serbia., Geronikaki A; School of Pharmacy, Aristotle University of Thessaloniki, Thessaloniki, Greece.

Publikováno v: SAR and QSAR in environmental research [SAR QSAR Environ Res] 2024 Feb; Vol. 35 (2), pp. 137-155. Date of Electronic Publication: 2024 Feb 05.