Zobrazeno 1 - 10
of 269
pro vyhledávání: '"N McFarland"'
Autor:
Breton M. Asken, Jesse C. DeSimone, Wei‐En Wang, Karen N. McFarland, Franchesca Arias, Shellie‐Anne Levy, Jacob Fiala, Idaly Velez‐Uribe, Robin P. Mayrand, Luana Okino Sawada, Christian Freytes, Michael Adeyosoye, Warren W. Barker, Elizabeth A. Crocco, Steven T. DeKosky, Malek Adjouadi, Monica Rosselli, Michael Marsiske, Melissa J. Armstrong, Glenn E. Smith, Rosie Curiel Cid, David A. Loewenstein, David E. Vaillancourt, Ranjan Duara
Publikováno v:
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 16, Iss 3, Pp n/a-n/a (2024)
Abstract INTRODUCTION Commercially available plasma p‐tau217 biomarker tests are not well studied in ethnically diverse samples. METHODS We evaluated associations between ALZPath plasma p‐tau217 and amyloid‐beta positron emission tomography (A
Externí odkaz:
https://doaj.org/article/6a96aa6ce47742c6a1d4d3c40f5209d4
Autor:
Darren M. Weber, Steven W. Taylor, Robert J. Lagier, Jueun C. Kim, Scott M. Goldman, Nigel J. Clarke, David E. Vaillancourt, Ranjan Duara, Karen N. McFarland, Wei-en Wang, Todd E. Golde, Michael K. Racke
Publikováno v:
Frontiers in Neurology, Vol 15 (2024)
IntroductionPlasma Aβ42/40 ratio can help predict amyloid PET status, but its clinical utility in Alzheimer’s disease (AD) assessment is unclear.MethodsAβ42/40 ratio was measured by LC-MS/MS for 250 specimens with associated amyloid PET imaging,
Externí odkaz:
https://doaj.org/article/9e471991a0474d5183e46f090a18bcfb
Autor:
Brenda D. Moore, Yong Ran, Marshall S. Goodwin, Kavitha Komatineni, Karen N. McFarland, Kristy Dillon, Caleb Charles, Danny Ryu, Xuefei Liu, Stefan Prokop, Benoit I. Giasson, Todd E. Golde, Yona Levites
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 31, Iss , Pp 101146- (2023)
Enhancing production of protein cargoes delivered by gene therapies can improve efficacy by reducing the amount of vector or simply increasing transgene expression levels. We explored the utility of a 126-amino acid collagen domain (CD) derived from
Externí odkaz:
https://doaj.org/article/6b461f0d9cea453d8528a9ec5184a9ec
Autor:
Rosie E. Curiel Cid, Alexandra Ortega, Elizabeth A. Crocco, Diana Hincapie, Karen N. McFarland, Ranjan Duara, David Vaillancourt, Steven T. DeKosky, Glenn Smith, Efrosyni Sfakianaki, Monica Rosselli, Warren W. Barker, Malek Adjouadi, Yarlenis Barreto, Yuleidys Feito, David A. Loewenstein
Publikováno v:
Frontiers in Neurology, Vol 14 (2023)
IntroductionSemantic intrusion errors (SI) have distinguished between those with amnestic Mild Cognitive Impairment (aMCI) who are amyloid positive (A+) versus negative (A−) on positron emission tomography (PET).MethodThis study examines the associ
Externí odkaz:
https://doaj.org/article/87f35fb535f44e528cdd626c4e68d841
Autor:
Kristen R. Ibanez, Karen N. McFarland, Jennifer Phillips, Mariet Allen, Christian B. Lessard, Lillian Zobel, Elsa Gonzalez De La Cruz, Shivani Shah, Quan Vo, Xue Wang, Zachary Quicksall, Daniel Ryu, Cory Funk, Nilüfer Ertekin-Taner, Stefan Prokop, Todd E. Golde, Paramita Chakrabarty
Publikováno v:
Alzheimer’s Research & Therapy, Vol 14, Iss 1, Pp 1-27 (2022)
Abstract Background The S209F variant of Abelson Interactor Protein 3 (ABI3) increases risk for Alzheimer’s disease (AD), but little is known about its function in relation to AD pathogenesis. Methods Here, we use a mouse model that is deficient in
Externí odkaz:
https://doaj.org/article/38aa23abced645f493a2c58c36ef5035
Autor:
Yona Levites, Cory Funk, Xue Wang, Paramita Chakrabarty, Karen N. McFarland, Baxter Bramblett, Veronica O’Neal, Xufei Liu, Thomas Ladd, Max Robinson, Mariet Allen, Minerva M. Carrasquillo, Dennis Dickson, Pedro Cruz, Danny Ryu, Hong-Dong Li, Nathan D. Price, NIlüfer Ertekin-Taner, Todd E. Golde
Publikováno v:
Molecular Neurodegeneration, Vol 16, Iss 1, Pp 1-13 (2021)
Abstract Introduction Passive immunotherapies targeting Aβ continue to be evaluated as Alzheimer’s disease (AD) therapeutics, but there remains debate over the mechanisms by which these immunotherapies work. Besides the amount of preexisting Aβ d
Externí odkaz:
https://doaj.org/article/5cbc36a13bfa43ad8efc899620b03275
Autor:
Samuel G. Cockey, Karen N. McFarland, Emily J. Koller, Mieu M. T. Brooks, Elsa Gonzalez De La Cruz, Pedro E. Cruz, Carolina Ceballos-Diaz, Awilda M. Rosario, Yona R. Levites, David R. Borchelt, Todd E. Golde, Benoit I. Giasson, Paramita Chakrabarty
Publikováno v:
npj Parkinson's Disease, Vol 7, Iss 1, Pp 1-14 (2021)
Abstract Parkinson’s disease (PD) and related synucleinopathies are characterized by chronic neuroinflammation leading to the premise that anti-inflammatory therapies could ameliorate synucleinopathy and associated sequelae. To test this idea, we u
Externí odkaz:
https://doaj.org/article/7d31e8435b0349f4ac0351ba14562121
Autor:
Grace M. Lloyd, Jorge A. Trejo-Lopez, Yuxing Xia, Karen N. McFarland, Sarah J. Lincoln, Nilüfer Ertekin-Taner, Benoit I. Giasson, Anthony T. Yachnis, Stefan Prokop
Publikováno v:
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-9 (2020)
Abstract The discovery of mutations associated with familial forms of Alzheimer’s disease (AD), has brought imperative insights into basic mechanisms of disease pathogenesis and progression and has allowed researchers to create animal models that a
Externí odkaz:
https://doaj.org/article/6c787f0501c440fe8c86864b1fb534c4
Autor:
Zachary A. Sorrentino, Marshall S. Goodwin, Cara J. Riffe, Jess-Karan S. Dhillon, Yuxing Xia, Kimberly-Marie Gorion, Niran Vijayaraghavan, Karen N. McFarland, Lawrence I. Golbe, Anthony T. Yachnis, Benoit I. Giasson
Publikováno v:
Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-22 (2019)
Abstract The protein α-synuclein (αsyn) forms pathologic aggregates in a number of neurodegenerative diseases including Lewy body dementia (LBD) and Parkinson’s disease (PD). It is unclear why diseases such as LBD may develop widespread αsyn pat
Externí odkaz:
https://doaj.org/article/7c196ce515fb4cd7b1a8e539e124d090
Autor:
Aditya R. Nayak, Houshuo Jiang, Margaret L. Byron, James M. Sullivan, Malcolm N. McFarland, David W. Murphy
Publikováno v:
Frontiers in Marine Science, Vol 8 (2021)
Externí odkaz:
https://doaj.org/article/d4261d7a96124835a9e148a57d94be0b