Zobrazeno 1 - 10
of 185
pro vyhledávání: '"N Maas"'
Autor:
Marijn N. Maas, Nurgül Bilgin, Laust Moesgaard, Jordi C. J. Hintzen, Anna Drozak, Jakub Drozak, Jacob Kongsted, Jasmin Mecinović
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract The Nτ-His73 methylation of β-actin by histidine methyltransferase SETD3 is required for the integrity of the cellular cytoskeleton. Modulation of SETD3 activity in human cells facilitates cancer-like changes to the cell phenotype. SETD3 b
Externí odkaz:
https://doaj.org/article/fecfdbdb30a34ff9b436833ffe6729a7
Autor:
Mark P. van Opijnen, Marike L. D. Broekman, Filip Y. F. de Vos, Edwin Cuppen, Jacobus J. M. van der Hoeven, Myra E. van Linde, Annette Compter, Laurens V. Beerepoot, Martin J. van den Bent, Maaike J. Vos, Helle-Brit Fiebrich, Johan A. F. Koekkoek, Ann Hoeben, Kuan H. Kho, Chantal M. L. Driessen, Hanne-Rinck Jeltema, Pierre A. J. T. Robe, Sybren L. N. Maas
Publikováno v:
BMC Medical Genomics, Vol 15, Iss 1, Pp 1-8 (2022)
Abstract Background Glioblastoma (GBM), the most common glial primary brain tumour, is without exception lethal. Every year approximately 600 patients are diagnosed with this heterogeneous disease in The Netherlands. Despite neurosurgery, chemo -and
Externí odkaz:
https://doaj.org/article/cfe094ec48aa400ca623264ad921e979
Publikováno v:
Open Journal of Occupational Therapy, Vol 10, Iss 3, Pp 1-5 (2022)
On March 11, 2020, the World Health Organization declared the outbreak of the coronavirus disease 2019 (COVID-19) as a global pandemic. Hospitals, nursing homes, and communities worldwide were flooded with patients diagnosed with COVID-19, resulting
Externí odkaz:
https://doaj.org/article/c69a77e632a64fe98e4113e8e9451bcd
Autor:
Sybren L. N. Maas, Erik R. Abels, Lieke L. Van De Haar, Xuan Zhang, Liza Morsett, Srinjoy Sil, Joana Guedes, Pritha Sen, Shilpa Prabhakar, Suzanne E. Hickman, Charles P. Lai, David T. Ting, Xandra O. Breakefield, Marike L. D. Broekman, Joseph El Khoury
Publikováno v:
Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-18 (2020)
Abstract Background Glioblastomas are the most common and lethal primary brain tumors. Microglia, the resident immune cells of the brain, survey their environment and respond to pathogens, toxins, and tumors. Glioblastoma cells communicate with micro
Externí odkaz:
https://doaj.org/article/b9621698f61b420098d1d9686658007c
Autor:
Thomas S. van Solinge, Erik R. Abels, Lieke L. van de Haar, Killian S. Hanlon, Sybren L. N. Maas, Rosalie Schnoor, Jeroen de Vrij, Xandra O. Breakefield, Marike L. D. Broekman
Publikováno v:
Frontiers in Molecular Biosciences, Vol 7 (2020)
Introduction: Glioma cells exert influence over the tumor-microenvironment in part through the release of extracellular vesicles (EVs), membrane-enclosed structures containing proteins, lipids, and RNAs. In this study, we evaluated the function of Ra
Externí odkaz:
https://doaj.org/article/b0557c179e79404c881d03d2332a9977
Autor:
Maximilian Y Deng, Felix Hinz, Sybren L N Maas, Günes Anil, Philipp Sievers, Cristina Conde-Lopez, Jonathan Lischalk, Sophie Rauh, Tanja Eichkorn, Sebastian Regnery, Lukas Bauer, Thomas Held, Eva Meixner, Kristin Lang, Juliane Hörner-Rieber, Klaus Herfarth, David Jones, Stefan M Pfister, Christine Jungk, Andreas Unterberg, Wolfgang Wick, Andreas von Deimling, Jürgen Debus, Felix Sahm, Laila König
Publikováno v:
Neuro-Oncology Advances.
Background The current CNS WHO classification of brain tumors distinguishes three malignancy grades in meningiomas, with increasing risk of recurrence from CNS WHO grade 1 to 3. Radiotherapy is recommended by current EANO guidelines for patients not
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ae42e77d60e4df6914a6634e8ff669f3
https://doi.org/10.1093/noajnl/vdad059
https://doi.org/10.1093/noajnl/vdad059
Autor:
M Castiglione, E Silva Cardoso, V A De Avila, N Maas Soldi, D Marques Nicastro, S Moura Rodrigues, F Benetti, L Da Silva Paiva, S Glina
Publikováno v:
The Journal of Sexual Medicine. 20
Introduction Female sexual dysfunctions (FSD) can influence mental and physical health, causing limitations in the ability to respond to or enjoy sexual pleasure. Obesity is related to diseases such as type II diabetes, heart disease and some types o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9a6c99560469b7c940037d3f928c79c9
https://doi.org/10.1093/jsxmed/qdad060.396
https://doi.org/10.1093/jsxmed/qdad060.396
Autor:
Robert Vogel, Frank A. W. Coumans, Raluca G. Maltesen, Anita N. Böing, Katherine E. Bonnington, Marike L. Broekman, Murray F. Broom, Edit I. Buzás, Gunna Christiansen, Najat Hajji, Søren R. Kristensen, Meta J. Kuehn, Sigrid M. Lund, Sybren L. N. Maas, Rienk Nieuwland, Xabier Osteikoetxea, Rosalie Schnoor, Benjamin J. Scicluna, Mitch Shambrook, Jeroen de Vrij, Stephen I. Mann, Andrew F. Hill, Shona Pedersen
Publikováno v:
Journal of Extracellular Vesicles, Vol 5, Iss 0, Pp 1-13 (2016)
Background: Understanding the pathogenic role of extracellular vesicles (EVs) in disease and their potential diagnostic and therapeutic utility is extremely reliant on in-depth quantification, measurement and identification of EV sub-populations. Qua
Externí odkaz:
https://doaj.org/article/456e048ddbcd4679b521f6fe03db04e9
Autor:
Jasmin Mecinović, Thomas J. Boltje, Paul B. White, Sabine G H A Langens, Jordi C. J. Hintzen, Jona Merx, Marijn N. Maas
Publikováno v:
Organic & Biomolecular Chemistry, 20, pp. 173-181
Organic & Biomolecular Chemistry, 20, 173-181
Hintzen, J C J, Merx, J, Maas, M N, Langens, S G H A, White, P B, Boltje, T J & Mecinović, J 2022, ' Amide-derived lysine analogues as substrates and inhibitors of histone lysine methyltransferases and acetyltransferases ', Organic & Biomolecular Chemistry, vol. 20, no. 1, pp. 173-181 . https://doi.org/10.1039/D1OB02191E
Organic & Biomolecular Chemistry, 20, 173-181
Hintzen, J C J, Merx, J, Maas, M N, Langens, S G H A, White, P B, Boltje, T J & Mecinović, J 2022, ' Amide-derived lysine analogues as substrates and inhibitors of histone lysine methyltransferases and acetyltransferases ', Organic & Biomolecular Chemistry, vol. 20, no. 1, pp. 173-181 . https://doi.org/10.1039/D1OB02191E
Histone lysine methyltransferases and acetyltransferases are two classes of epigenetic enzymes that play pivotal roles in human gene regulation. Although they both recognise and posttranslationally modify lysine residues in histone proteins, their di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87241cab85a70f6f85b3dc91d045d05b
https://doi.org/10.1039/d1ob02191e
https://doi.org/10.1039/d1ob02191e
Autor:
Nurgül Bilgin, Laust Moesgaard, Marijn N. Maas, Jordi C. J. Hintzen, Apolonia Witecka, Jakub Drozak, Jacob Kongsted, Jasmin Mecinović
Publikováno v:
Bilgin, N, Moesgaard, L, Maas, M, Hintzen, J, Witecka, A, Drozak, J, Kongsted, J & Mecinović, J 2022, ' Importance of Ile71 in β-actin on histidine methyltransferase SETD3 catalysis ', Organic & Biomolecular Chemistry, vol. 20, no. 8, 1723, pp. 1723-1730 . https://doi.org/10.1039/D1OB02430B
SETD3-catalysed N3-methylation of His73 in β-actin plays a key role in stabilisation of actin filaments in the metazoan cells. Overexpression and/or dysregulation of SETD3 is associated with several human pathologies, including cancer. Here, we exam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6da12690101080c2de8d766287e718d1
https://doi.org/10.1039/d1ob02430b
https://doi.org/10.1039/d1ob02430b