Výsledky vyhledávání - "N M, Nathanson"

Phosphorylation of human gp130 at Ser-782 adjacent to the Di-leucine internalization motif. Effects on expression and signaling

Autor: R M, Gibson, W P, Schiemann, L B, Prichard, J M, Reno, L H, Ericsson, N M, Nathanson

Publikováno v: The Journal of biological chemistry. 275(29)

The receptor for leukemia inhibitory factor (LIF) consists of two polypeptides, the LIF receptor and gp130. Agonist stimulation has been shown previously to cause phosphorylation of gp130 on serine, threonine, and tyrosine residues. We found that gp1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::764997f42f04ec7e670a7b05ac3e4af1
https://pubmed.ncbi.nlm.nih.gov/10811661

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Tyrosines 905 and 915 of gp130 are required for maximum induction of m2 muscarinic acetylcholine receptor and VIP gene transcription by cytokines in neuronal cells

Autor: M L, Rosoff, N M, Nathanson

Publikováno v: Cellular and molecular neurobiology. 19(2)

1. Leukemia inhibitory factor action is mediated by a heterodimeric receptor consisting of two subunits, gp130 and the low-affinity leukemia inhibitory factor receptor (LIFR). 2. We used chimeric receptors containing the intracellular domain of eithe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c08a4fbfb5436ead05e7f4812ee35261
https://pubmed.ncbi.nlm.nih.gov/10081611

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Identification and localization of muscarinic acetylcholine receptors in the ocular tissues of the chick

Autor: A J, Fischer, L A, McKinnon, N M, Nathanson, W K, Stell

Publikováno v: The Journal of comparative neurology. 392(3)

The purpose of this study was to characterize the distribution of muscarinic acetylcholine receptors (mAChRs) in the ocular tissues of hatched chicks. In the chick, different isoforms of these receptors have been detected in the brain, heart, and ret

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::07bbac1b500df942913cddca0d9590a8
https://pubmed.ncbi.nlm.nih.gov/9511918

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Box 3-independent signaling mechanisms are involved in leukemia inhibitory factor receptor alpha- and gp130-mediated stimulation of mitogen-activated protein kinase. Evidence for participation of multiple signaling pathways which converge at Ras

Autor: W P, Schiemann, J L, Bartoe, N M, Nathanson

Publikováno v: The Journal of biological chemistry. 272(26)

Chimeric receptors containing the entire or various cytoplasmic domains of either gp130 or leukemia inhibitory factor receptor alpha (LIFR) were used to identify signaling molecules and regions of these polypeptides required for the stimulation of mi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cc3a1e3a0665f8033f2069a499496cf2
https://pubmed.ncbi.nlm.nih.gov/9195977

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Differential localization of G-proteins, G alpha o and G alpha i-1, -2, and -3, in polarized epithelial MDCK cells

Autor: S E, Hamilton, N M, Nathanson

Publikováno v: Biochemical and biophysical research communications. 234(1)

MDCK cells were stably transfected with rat G alpha o cDNA and confluent polarized monolayers were analyzed by immunocytochemistry to compare the intracellular targeting of G alpha o with the localization of the endogenously expressed G alpha i subun

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::176f7c013d7ddfda385f3ea95d505eeb
https://pubmed.ncbi.nlm.nih.gov/9168949

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Regulation of muscarinic acetylcholine receptor expression and function

Autor: N M, Nathanson

Publikováno v: Progress in brain research. 109

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fdacd67a7930ef1fc09a73dce90f8656
https://pubmed.ncbi.nlm.nih.gov/9009703

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Regulation of cAMP-mediated gene transcription by wild type and mutated G-protein alpha subunits. Inhibition of adenylyl cyclase activity by muscarinic receptor-activated and constitutively activated G(o) alpha

Autor: J C, Migeon, S L, Thomas, N M, Nathanson

Publikováno v: The Journal of biological chemistry. 269(46)

We have used a luciferase reporter gene under the transcriptional control of a cAMP response element (CRE) to monitor the effects of G-protein alpha subunits on cAMP-regulated gene expression and to examine muscarinic acetylcholine receptor (mAChR) f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4711fd29ce6cf98b6f9dbdcc21a02d66
https://pubmed.ncbi.nlm.nih.gov/7961880

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Differential requirements for p21ras and protein kinase C in the regulation of neuronal gene expression by nerve growth factor and neurokines

Autor: J A, Johnson, N M, Nathanson

Publikováno v: The Journal of biological chemistry. 269(29)

This study used reporter gene constructs containing regulatory regions of the c-fos, vasoactive intestinal peptide, and choline acetyltransferase genes to determine the role of p21ras and protein kinase C in the action of ciliary neurotrophic factor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d123458096c32bf34f8ded828e46f454
https://pubmed.ncbi.nlm.nih.gov/8034640

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Differential role of the carboxyl-terminal tyrosine in down-regulation and sequestration of the m2 muscarinic acetylcholine receptor

Autor: P S, Goldman, N M, Nathanson

Publikováno v: The Journal of biological chemistry. 269(22)

Muscarinic acetylcholine receptor (mAChR) number can be altered in response to sustained agonist exposure. Short term agonist exposure (seconds to minutes) causes a rapid removal of mAChR from the cell surface (sequestration) while agonist exposure f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::35cca877962e409ae88e0835425a9f4f
https://pubmed.ncbi.nlm.nih.gov/8195213

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Differential regulation of cAMP-mediated gene transcription by m1 and m4 muscarinic acetylcholine receptors. Preferential coupling of m4 receptors to Gi alpha-2

Autor: J C, Migeon, N M, Nathanson

Publikováno v: The Journal of biological chemistry. 269(13)

We have used a luciferase reporter gene under the transcriptional control of a cAMP response element as a sensitive monitor of the regulation by muscarinic acetylcholine receptors (mAChRs) of intracellular cAMP levels and cAMP-regulated gene expressi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::89c3ed66eac63465e2cfbb3917a5d054
https://pubmed.ncbi.nlm.nih.gov/8144570

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