Zobrazeno 1 - 10
of 27
pro vyhledávání: '"N M, Mironov"'
Autor:
N M, Mironov, M A, Aguelon, G I, Potapova, Y, Omori, O V, Gorbunov, A A, Klimenkov, H, Yamasaki
Publikováno v:
Cancer research. 54(1)
We have examined whether alterations of simple (CA)n DNA repeats, as observed in human colon cancers, occur during human gastric carcinogenesis and whether such alterations reflect genomic instability that could lead to other genetic changes. A total
Publikováno v:
Bulletin of Experimental Biology and Medicine. 93:616-620
In the modern view nuclear skeletal structures (the nuclear matrix) play an extremely important role in the structural organization of chromatin [12]. There is evidence that differences in the degree of compactness of active and inactive chromatin in
Autor:
N. M. Mironov
Publikováno v:
Bulletin of Experimental Biology and Medicine. 104:1455-1458
Publikováno v:
Bulletin of Experimental Biology and Medicine. 80:975-978
Mustine inhibits the template activity of chromatin and DNA in an RNA-polymerase system in vitro much more strongly than its monofunctional analogue. Chromatin is more sensitive to the action of mustine than is deproteinized DNA. However, the templat
Publikováno v:
Bulletin of Experimental Biology and Medicine. 106:1165-1168
The problem of whether metabolites of chemical carcinogens interact with the genetic material of the cell in random fashion, or whether targets modified by carcinogens with the greatest intensity exist in DNA is of the utmost importance for the under
Publikováno v:
Bulletin of Experimental Biology and Medicine. 90:1378-1380
1 h in 1.5, 0.9, 0.6, 0.4, 0.3, 0.2, and 0.i M, then overnight against urea in Na-acetate buffer, followed by 4 h against i0 mM Tris-HCl buffer, pH 8.0. Phenylmethylsulfanyl fluoride was present in all solutions. Electrophoresis of the chromatin prot
Publikováno v:
Bulletin of Experimental Biology and Medicine. 89:136-138
By washing and subsequent centrifugation of rat liver nuclei in medium of low ionic strength the chromatin can be separated into two fractions: Chromatin eluting into the supernatant and chromatin firmly bound with the matrix. The chromatin fraction
Publikováno v:
Bulletin of Experimental Biology and Medicine. 87:20-22
With the aid of various activation systems, polycyclic aromatic hydrocarbons (PAH) were bound covalently with DNA. The following activation systems were used: with the microsomal fraction of rat liver, with I2, and with ascorbic acid and FeSO4. In al
Publikováno v:
Bulletin of Experimental Biology and Medicine. 93:254-256
Publikováno v:
Bulletin of Experimental Biology and Medicine. 81:436-438
Male rats were kept on a diet containing the carcinogen 3′-methyl-4-dimethylaminoazobenzene. No difference from the control was found either in the electrophoretic spectrum of the total protein of deoxyribonucleoproteins (DNP) or nonhistone protein