Zobrazeno 1 - 10
of 10
pro vyhledávání: '"N Lance, Hepler"'
Autor:
David B. Jaffe, Payam Shahi, Bruce A. Adams, Ashley M. Chrisman, Peter M. Finnegan, Nandhini Raman, Ariel E. Royall, FuNien Tsai, Thomas Vollbrecht, Daniel S. Reyes, N. Lance Hepler, Wyatt J. McDonnell
Publikováno v:
Nature. 611:352-357
The vertebrate adaptive immune system modifies the genome of individual B cells to encode antibodies that bind particular antigens1. In most mammals, antibodies are composed of heavy and light chains that are generated sequentially by recombination o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::35d6489358e6f3877a19040f9a3c09dc
https://doi.org/10.1038/s41586-022-05371-z
https://doi.org/10.1038/s41586-022-05371-z
Autor:
Audrey Hemadou, Véronique Giudicelli, Melissa Laird Smith, Marie-Paule Lefranc, Patrice Duroux, Sofia Kossida, Cheryl Heiner, N. Lance Hepler, John Kuijpers, Alexis Groppi, Jonas Korlach, Philippe Mondon, Florence Ottones, Marie-Josée Jacobin-Valat, Jeanny Laroche-Traineau, Gisèle Clofent-Sanchez
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
Phage-display selection of immunoglobulin (IG) or antibody single chain Fragment variable (scFv) from combinatorial libraries is widely used for identifying new antibodies for novel targets. Next-generation sequencing (NGS) has recently emerged as a
Externí odkaz:
https://doaj.org/article/9295a62022e7429ca9a82b81567e8178
Autor:
Brittany Rife Magalis, Stephanie J. Spielman, Ben Murrell, Sadie R Wisotsky, Simon D. W. Frost, Dave Bouvier, Ryan Velazquez, Art F. Y. Poon, Spencer V. Muse, N. Lance Hepler, Sergei L Kosakovsky Pond, Stephen D. Shank, Anton Nekrutenko, Steven Weaver
Publikováno v:
Mol Biol Evol
HYpothesis testing using PHYlogenies (HyPhy) is a scriptable, open-source package for fitting a broad range of evolutionary models to multiple sequence alignments, and for conducting subsequent parameter estimation and hypothesis testing, primarily i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f2726ff45bdf76bef80d72b39b3f6c4
https://doi.org/10.1093/molbev/msz197
https://doi.org/10.1093/molbev/msz197
Autor:
N Lance Hepler, Konrad Scheffler, Steven Weaver, Ben Murrell, Douglas D Richman, Dennis R Burton, Pascal Poignard, Davey M Smith, Sergei L Kosakovsky Pond
Publikováno v:
PLoS Computational Biology, Vol 10, Iss 9, p e1003842 (2014)
Since its identification in 1983, HIV-1 has been the focus of a research effort unprecedented in scope and difficulty, whose ultimate goals--a cure and a vaccine--remain elusive. One of the fundamental challenges in accomplishing these goals is the t
Externí odkaz:
https://doaj.org/article/68f8c9d0586541d3b58b57af20d44a30
Autor:
Antoine Chaillon, Gabriela Arantes Wagner, Gemma Caballero, N. Lance Hepler, Douglas D. Richman, Terri Wrin, Pham Phung, Joel O. Wertheim, Mary E. Pacold, Sergei L. Kosakovsky Pond, Susan J. Little, Davey M. Smith
Publikováno v:
Journal of Virology. 87:12737-12744
Investigating the incidence and prevalence of HIV-1 superinfection is challenging due to the complex dynamics of two infecting strains. The superinfecting strain can replace the initial strain, be transiently expressed, or persist along with the init
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fd77526b782edbe6ba588a314dffc7c
https://doi.org/10.1128/jvi.02260-13
https://doi.org/10.1128/jvi.02260-13
Autor:
Douglas D. Richman, Davey M. Smith, N. Lance Hepler, Joel O. Wertheim, Sanjay Mehta, Sergei L. Kosakovsky Pond, Andrew J. Leigh Brown
Publikováno v:
The Journal of Infectious Diseases
Human immunodeficiency virus type 1 (HIV-1) is pandemic, but its contemporary global transmission network has not been characterized. A better understanding of the properties and dynamics of this network is essential for surveillance, prevention, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26a28795f144d553a6ea9e4be2934cd2
https://doi.org/10.1093/infdis/jit524
https://doi.org/10.1093/infdis/jit524
Autor:
Konrad Scheffler, Dennis R. Burton, Douglas D. Richman, N. Lance Hepler, Sergei L. Kosakovsky Pond, Ben Murrell, Steven Weaver, Pascal Poignard, Davey M. Smith
Publikováno v:
PLoS Computational Biology
PLoS Computational Biology, Vol 10, Iss 9, p e1003842 (2014)
PLoS Computational Biology, Vol 10, Iss 9, p e1003842 (2014)
Since its identification in 1983, HIV-1 has been the focus of a research effort unprecedented in scope and difficulty, whose ultimate goals — a cure and a vaccine – remain elusive. One of the fundamental challenges in accomplishing these goals is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df9bd704c3f8c4d7c128c280ade03f1c
http://europepmc.org/articles/PMC4177671
http://europepmc.org/articles/PMC4177671
Autor:
Douglas D. Richman, Sergei L. Kosakovsky Pond, N. Lance Hepler, Art F. Y. Poon, Wayne Delport, M. D. Smith, Konrad Scheffler
Publikováno v:
ICCABS
The 454 sequencing platform enables new investigatory methods for characterizing the diversity of a population, but is prone to sequencing errors such as homopolymer length miscalls which can lead to frame shift errors in analyses of protein coding s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f0f846b181f2159f4012e494251de735
https://doi.org/10.1109/iccabs.2012.6182677
https://doi.org/10.1109/iccabs.2012.6182677
Akademický článek
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Conference
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