Transcriptomics, metabolomics, and in-silico drug predictions for liver damage in young and aged burn victims

Autor: Beata Malachowska, Weng-Lang Yang, Andrea Qualman, Israel Muro, Devin M. Boe, Jed N. Lampe, Elizabeth J. Kovacs, Juan-Pablo Idrovo

Publikováno v: Communications Biology, Vol 6, Iss 1, Pp 1-11 (2023)

Abstract Burn induces a systemic response affecting multiple organs, including the liver. Since the liver plays a critical role in metabolic, inflammatory, and immune events, a patient with impaired liver often exhibits poor outcomes. The mortality r

Externí odkaz: https://doaj.org/article/3902d53e7c5e4be794ef1dc208f20f0f

A catalogue of unusually long thermonuclear bursts on neutron stars

Autor: K Alizai, J Chenevez, A Cumming, N Degenaar, M Falanga, D K Galloway, J J M in ’t Zand, G K Jaisawal, L Keek, E Kuulkers, N Lampe, H Schatz, M Serino

Publikováno v: Alizai, K, Chenevez, J, Cumming, A, Degenaar, N, Falanga, M, Galloway, D K, In 'T Zand, J J M, Jaisawal, G K, Keek, L, Kuulkers, E, Lampe, N, Schatz, H & Serino, M 2023, ' A catalogue of unusually long thermonuclear bursts on neutron stars ', Monthly Notices of the Royal Astronomical Society, vol. 521, no. 3, pp. 3608-3624 . https://doi.org/10.1093/mnras/stad374

Rare, energetic (long) thermonuclear (Type I) X-ray bursts are classified either as intermediate-duration or ‘supern’ bursts, based on their duration. Intermediate-duration bursts lasting a few to tens of minutes are thought to arise from the the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd7e937154855e00a6c0da1c9842ea4c
https://doi.org/10.1093/mnras/stad374

Aqueous synthesis of a small-molecule lanthanide chelator amenable to copper-free click chemistry.

Autor: Stephanie C Bishop, Robert Winefield, Asokan Anbanandam, Jed N Lampe

Publikováno v: PLoS ONE, Vol 14, Iss 3, p e0209726 (2019)

The lanthanides (Ln3+), or rare earth elements, have proven to be useful tools for biomolecular NMR, X-ray crystallographic, and fluorescence analyses due to their unique 4f orbitals. However, their utility in biological applications has been limited

Externí odkaz: https://doaj.org/article/82038a31b60a42d09778c77ad77dcf51

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Cefadroxil Comparable to Cephalexin: Minimum Inhibitory Concentrations among Methicillin-Susceptible Staphylococcus aureus Isolates from Pediatric Musculoskeletal Infections

Autor: Andrew S. Haynes, Andrea Prinzi, Lori J. Silveira, Sarah K. Parker, Jed N. Lampe, Jeffrey S. Kavanaugh, Alexander R. Horswill, Douglas Fish

Publikováno v: Microbiology spectrum. 10(4)

Cephalexin and cefadroxil are oral first-generation cephalosporins used to treat methicillin-susceptible Staphylococcus aureus (MSSA) infections. Despite its shorter half-life, cephalexin is more frequently prescribed, although cefadroxil is an appea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa25fb097597557cdc2f29a60de8f7a6
https://pubmed.ncbi.nlm.nih.gov/35730963