Meta-analysis of Genome-wide Association Studies for Neuroticism, and the Polygenic Association With Major Depressive Disorder

Autor: Igor Rudan, Barbara Franke, Margaret J. Wright, Juho Wedenoja, Laura J. Bierut, Anjali K. Henders, Teresa Nutile, Andrew C. Heath, Joost G. E. Janzing, Anu Realo, Ilkka Seppälä, Lindsay K. Matteson, Nicholas J. Timpson, Tõnu Esko, Arpana Agrawal, Abraham A. Palmer, Rossella Sorice, Andres Metspalu, Patrik K. E. Magnusson, Aarno Palotie, Katja Appel, Elisabeth Widen, Ozren Polasek, Katri Räikkönen, Marleen H. M. de Moor, Matthew G. Kirkpatrick, Caroline Hayward, Hans Joergen Grabe, Ian J. Deary, Nicholas G. Martin, Karin J. H. Verweij, Klaasjan G. Ouwens, Alessandra Minelli, Angelina R. Sutin, William G. Iacono, Jennifer E. Huffman, Marina Ciullo, Dorret I. Boomsma, Harry Campbell, N. L. Pedersen, David J. Porteous, Timothy B. Bigdeli, Jasper Wouda, Jun Ding, Alexander Viktorin, David C. Liewald, Gonçalo R. Abecasis, Richard A. Grucza, Carsten Oliver Schmidt, Antti Latvala, James F. Wilson, Luigi Ferrucci, Erik Pettersson, Beate St Pourcain, Scott D. Gordon, Grant W. Montgomery, Stéphanie Martine van den Berg, Jaime Derringer, Yuri Milaneschi, Alexander Teumer, Holly Trochet, Daniel E. Adkins, Jaakko Kaprio, Brenda W.J.H. Penninx, Chiara Magri, Sita H. Vermeulen, Terho Lehtimäki, Alejandro Arias Vasquez, Harriet de Wit, Jari Lahti, Jouke-Jan Hottenga, Matt McGue, Johan G. Eriksson, Daniela Ruggiero, John P. Kemp, Toshiko Tanaka, Iryna O. Fedko, Jüri Allik, Yong Qian, Annette M. Hartmann, Cornelia M. van Duijn, Barbara E. Engelhardt, Laura Pulkki-Råback, Jonathan Marten, Pamela A. F. Madden, Olli T. Raitakari, Michelle Luciano, Robert Karlsson, Amy B. Hart, Gail Davies, Liisa Keltikangas-Järvinen, Robert F. Krueger, Narelle K. Hansell, Kati Heinonen, Georg Homuth, Eero Vuoksimaa, Wendy S. Slutske, Sarah E. Medland, Andrea Maschio, Najaf Amin, John M. Starr, Antonio Terracciano, David M. Evans, Markus Jokela, Lina Zgaga, Dan Rujescu, David Schlessinger, Ina Giegling, Matthias Nauck, John M. Hettema, Evelin Mihailov, Paul T. Costa, Michael B. Miller, Bettina Konte, Minyoung Lee, George Davey Smith, Fabio Busonero, Richard J. Rose

Publikováno v: JAMA Psychiatry
JAMA Psychiatry, 72(7), 642-650. American Medical Association
JAMA Psychiatry 72 (2015): 642–650. doi:10.1001/jamapsychiatry.2015.0554
info:cnr-pdr/source/autori:Genetics of Personality Consortium, de Moor MH, van den Berg SM, Verweij KJ, Krueger RF, Luciano M, Arias Vasquez A, Matteson LK, Derringer J, Esko T, Amin N, Gordon SD, Hansell NK, Hart AB, Seppälä I, Huffman JE, Konte B, Lahti J, Lee M, Miller M, Nutile T, Tanaka T, Teumer A, Viktorin A, Wedenoja J, Abecasis GR, Adkins DE, Agrawal A, Allik J, Appel K, Bigdeli TB, Busonero F, Campbell H, Costa PT, Davey Smith G, Davies G, de Wit H, Ding J, Engelhardt BE, Eriksson JG, Fedko IO, Ferrucci L, Franke B, Giegling I, Grucza R, Hartmann AM, Heath AC, Heinonen K, Henders AK, Homuth G, Hottenga JJ, Iacono WG, Janzing J, Jokela M, Karlsson R, Kemp JP, Kirkpatrick MG, Latvala A, Lehtimäki T, Liewald DC, Madden PA, Magri C, Magnusson PK, Marten J, Maschio A, Medland SE, Mihailov E, Milaneschi Y, Montgomery GW, Nauck M, Ouwens KG, Palotie A, Pettersson E, Polasek O, Qian Y, Pulkki-Råback L, Raitakari OT, Realo A, Rose RJ, Ruggiero D, Schmidt CO, Slutske WS, Sorice R, Starr JM, St Pourcain B, Sutin AR, Timpson NJ, Trochet H, Vermeulen S, Vuoksimaa E, Widen E, Wouda J, Wright MJ, Zgaga L, Porteous D, Minelli A, Palmer AA, Rujescu D, Ciullo M, Hayward C, Rudan I, Metspalu A, Kaprio J, Deary IJ, Räikkönen K, Wilson JF, Keltikangas-Järvinen L, Bierut LJ, Hettema JM, Grabe HJ, van Duijn CM, Evans DM, Schlessinger D, Pedersen NL, Terracciano A, McGue M, Penninx BW, Martin NG, Boomsma DI./titolo:Meta-analysis of Genome-wide Association Studies for Neuroticism, and the Polygenic Association With Major Depressive Disorder./doi:10.1001%2Fjamapsychiatry.2015.0554/rivista:JAMA Psychiatry/anno:2015/pagina_da:642/pagina_a:650/intervallo_pagine:642–650/volume:72
De Moor, M H M, Van Den Berg, S M, Verweij, K J H, Krueger, R F, Luciano, M, Arias Vasquez, A, Matteson, L K, Derringer, J, Esko, T, Amin, N, Gordon, S D, Hansell, N K, Hart, A B, Seppälä, I, Huffman, J E, Konte, B, Lahti, J, Lee, M, Miller, M, Nutile, T, Tanaka, T, Teumer, A, Viktorin, A, Wedenoja, J, Abecasis, G R, Adkins, D E, Agrawal, A, Allik, J, Appel, K, Bigdeli, T B, Busonero, F, Campbell, H, Costa, P T, Davey Smith, G, Davies, G, De Wit, H, Ding, J, Engelhardt, B E, Eriksson, J G, Fedko, I O, Ferrucci, L, Franke, B, Giegling, I, Grucza, R, Hartmann, A M, Heath, A C, Heinonen, K, Henders, A K, Homuth, G, Hottenga, J J, Iacono, W G, Janzing, J, Jokela, M, Karlsson, R, Kemp, J P, Kirkpatrick, M G, Latvala, A, Lehtimäki, T, Liewald, D C, Madden, P A F, Magri, C, Magnusson, P K E, Marten, J, Maschio, A, Medland, S E, Mihailov, E, Milaneschi, Y, Montgomery, G W, Nauck, M, Ouwens, K G, Palotie, A, Pettersson, E, Polasek, O, Qian, Y, Pulkki-Råback, L, Raitakari, O T, Realo, A, Rose, R J, Ruggiero, D, Schmidt, C O, Slutske, W S, Sorice, R, Starr, J M, St Pourcain, B, Sutin, A R, Timpson, N J, Trochet, H, Vermeulen, S, Vuoksimaa, E, Widen, E, Wouda, J, Wright, M J, Zgaga, L, Porteous, D, Minelli, A, Palmer, A A, Rujescu, D, Ciullo, M, Hayward, C, Rudan, I & McGue, M 2015, ' Meta-analysis of genome-wide association studies for neuroticism, and the polygenic association with major depressive disorder ', J A M A Psychiatry, vol. 72, no. 7, pp. 642-650 . https://doi.org/10.1001/jamapsychiatry.2015.0554
de Moor, M H M, van den Berg, S M, Verweij, C J H, Krueger, R F, Luciano, M, Arias-Vasquez, A, Matteson, L K, Derringer, J, Esko, T, Amin, N, Gordon, S D, Hansell, N K, Hart, A B, Seppälä, I, Huffman, J E, Konte, B, Lahti, J, Lee, M Y, Miller, M, Nutile, T, Tanaka, T, Teumer, A, Viktorin, A, Wedenoja, J, Abecasis, G R, Adkins, D E, Agrawal, A, Allik, J, Appel, K, Bigdeli, T B, Busonero, F, Campbell, H, Costa, P T, Davey Smith, G, Davies, G, de Wit, H, Ding, J, Engelhardt, B E, Eriksson, J G, Fedko, I O, Ferrucci, L, Franke, B, Giegling, I, Grucza, R, Hartmann, A M, Heath, A C, Heinonen, K, Henders, A K, Homuth, G, Hottenga, J J, Iacono, W G, Janzing, J, Jokela, M, Karlsson, R, Kemp, J P, Kirkpatrick, M G, Latvala, A, Lehtimäki, T, Liewald, D C, Madden, P A F, Magri, C, Magnusson, P K E, Marten, J, Maschio, A, Medland, S E, Mihailov, E, Milaneschi, Y, Montgomery, G W, Nauck, M, Ouwens, K G, Palotie, A, Pettersson, E, Polasek, O, Qian, Y, Pulkki-Råback, L, Raitakari, O T, Realo, A, Rose, R J, Ruggiero, D, Schmidt, C O, Slutske, W S, Sorice, R, Starr, J M, St Pourcain, B, Sutin, A R, Timpson, N J, Trochet, H, Vermeulen, S, Vuoksimaa, E, Widén, E, Wouda, J, Wright, M J, Zgaga, L, Porteous, D, Minelli, A, Palmer, A A, Rujescu, D, Ciullo, M, Hayward, C, Rudan, I, Metspalu, A, Kaprio, J, Deary, I J, Räikkönen, K, Wilson, J F, Keltikangas-Järvinen, L, Bierut, L J, Hettema, J M, Grabe, H J, van Duijn, C M, Evans, D M, Schlessinger, D, Pedersen, N L, Terracciano, A, McGue, M, Penninx, B W J H, Martin, N G & Boomsma, D I 2015, ' Meta-analysis of Genome-wide Association Studies for Neuroticism, and the Polygenic Association With Major Depressive Disorder ', JAMA Psychiatry, vol. 72, no. 7, pp. 642-650 . https://doi.org/10.1001/jamapsychiatry.2015.0554
JAMA Psychiatry, 72, 642-50
JAMA psychiatry, 72(7), 642-650. American Medical Association
JAMA Psychiatry, 72, 7, pp. 642-50

Contains fulltext : 153372.pdf (Publisher’s version ) (Closed access) IMPORTANCE: Neuroticism is a pervasive risk factor for psychiatric conditions. It genetically overlaps with major depressive disorder (MDD) and is therefore an important phenotyp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dea846ef40199b16b4b8d4da45b6948
https://doi.org/10.1001/jamapsychiatry.2015.0554

Genetic Effects for Plasma Factor VII Levels Independent of and in Common with Triglycerides

Autor: Yuling Hong, N. L. Pedersen, N. Egberg, U de Faire

Publikováno v: Thrombosis and Haemostasis. 81:382-386

Summary Background. Coagulation factor VII has been demonstrated as a potential risk factor for cardiovascular disease. Both genes and non-genetic factors are related to plasma levels of factor VII. However, the extent to which genetic effects influe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4f18fa045cd17c720dd9d5a5982bc1d2
https://doi.org/10.1055/s-0037-1614482

A twin study of generalized anxiety disorder and major depression

Autor: Michael C. Neale, A A Mathé, Kenneth S. Kendler, N L Pedersen, Marc-André Roy

Publikováno v: Psychological Medicine. 25:1037-1049

SYNOPSISPrevious analyses with a sample of female twins sampled from the general population in Virginia have suggested that generalized anxiety disorder (GAD) and major depression (MD) share their genetic determinants but have partly different enviro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94ff6f61ed1dd4390ce30ab917e0087d
https://doi.org/10.1017/s0033291700037533

Genetic and shared environmental factors do not confound the association between birth weight and hypertension: a study among Swedish twins

Autor: N. L. Pedersen, Ulf de Faire, Niklas Bergvall, Paul Lichtenstein, Anastasia Iliadou, Yudi Pawitan, Sven Cnattingius, Stefan Johansson, Michael S. Kramer

Publikováno v: Circulation. 115(23)

Background— Studies have found associations between low birth weight and increased risks of cardiovascular diseases in adulthood. However, these associations could be due to confounding by genetic or socioeconomic factors. Methods and Results— We

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbb520e6b164d413225ff78c4f390a4f
https://pubmed.ncbi.nlm.nih.gov/17515462

Extra-intestinal manifestations associated with irritable bowel syndrome: a twin study

Autor: P, Svedberg, S, Johansson, M-A, Wallander, B, Hamelin, N L, Pedersen

Publikováno v: Alimentary pharmacologytherapeutics. 16(5)

Little is known about the role of genetic and environmental factors in irritable bowel syndrome. Various extra-intestinal manifestations are more prevalent in cases than in controls. Genetic effects may be important in the liability to develop functi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::59299d20aa0af0f3e34bc4636e2a2b06
https://pubmed.ncbi.nlm.nih.gov/11966507