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Autor:
Rodrigo A.C. Sussmann, Fernando G. de Almeida, Mauro F Azevedo, Emilia A. Kimura, H R Melo, Marcell Crispim, C A Zafra, Ignasi Bofill Verdaguer, Alejandro M. Katzin, N L Buriticá
Publikováno v:
Antimicrob Agents Chemother
Atovaquone (AV) acts on the malaria parasite by competing with ubiquinol (UQH(2)) for its union to the mitochondrial bc(1) complex, preventing the ubiquinone-8 and ubiquinone-9 (UQ-8 and UQ-9) redox recycling, which is a necessary step in pyrimidine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1be3ad2bf42c03fd69cd8aa66e00d376
https://doi.org/10.1128/aac.01516-20
https://doi.org/10.1128/aac.01516-20
