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The steroid-dependent regulatory element in the ovalbumin gene does not function as a typical steroid response element

Autor: Michel M. Sanders, L. A. Schweers, N. L. Weigel, D. E. Frank

Publikováno v: Journal of Biological Chemistry. 265:7590-7595

Transcription of the chicken ovalbumin gene is induced both in vivo and in vitro by four classes of steroid hormones. Recent experiments identified a steroid-dependent regulatory element (SDRE) in the 5'-flanking region of the ovalbumin gene between

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eb8afc0f9904506dcc29ace792db2ef7
https://doi.org/10.1016/s0021-9258(19)39155-0

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Androgen receptors and their biology

Autor: D J, Lamb, N L, Weigel, M, Marcelli

Publikováno v: Vitamins and hormones. 62

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d5b3d2ef7d1cea6f9cb1ef63d57bc4f2
https://pubmed.ncbi.nlm.nih.gov/11345899

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A calcitriol analogue, EB1089, inhibits the growth of LNCaP tumors in nude mice

Autor: S E, Blutt, T C, Polek, L V, Stewart, M W, Kattan, N L, Weigel

Publikováno v: Cancer research. 60(4)

Limited options for the treatment of prostate cancer have spurred the search for new therapies. One innovative approach is the use of 1alpha,25-dihydroxyvitamin D3 (calcitriol) analogues to inhibit cancer growth. We demonstrate here that the calcitri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bcba9d257a70e070568d5e345a2edba3
https://pubmed.ncbi.nlm.nih.gov/11358859

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Androgen receptor mutations in prostate cancer

Autor: M, Marcelli, M, Ittmann, S, Mariani, R, Sutherland, R, Nigam, L, Murthy, Y, Zhao, D, DiConcini, E, Puxeddu, A, Esen, J, Eastham, N L, Weigel, D J, Lamb

Publikováno v: Cancer research. 60(4)

We analyzed the frequency and relevance of mutations in the coding region of the androgen receptor (AR) in genomic DNA extracted from 137 specimens of prostate cancer. The specimens were obtained from the primary tumors of patients affected by stage

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::213e2c779faee10b12ecbe3686f09200
https://pubmed.ncbi.nlm.nih.gov/10706109

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Phosphorylation of steroid receptor coactivator-1. Identification of the phosphorylation sites and phosphorylation through the mitogen-activated protein kinase pathway

Autor: B G, Rowan, N L, Weigel, B W, O'Malley

Publikováno v: The Journal of biological chemistry. 275(6)

Steroid receptor coactivator-1 (SRC-1) is a member of a coactivator family that enhance the activation of the steroid/nuclear receptor superfamily of ligand-stimulated transcription factors. To study the regulation of SRC-1 by signaling pathways in t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fa87fcd30ca229312c9595074480a793
https://pubmed.ncbi.nlm.nih.gov/10660621

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Calcitriol-induced apoptosis in LNCaP cells is blocked by overexpression of Bcl-2

Autor: S E, Blutt, T J, McDonnell, T C, Polek, N L, Weigel

Publikováno v: Endocrinology. 141(1)

While the role of vitamin D in bone and mineral metabolism has been investigated extensively, the role of the vitamin D receptor in other tissues is less well understood. 1,25-Dihydroxyvitamin D3 (calcitriol) can act as a differentiating agent in nor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::42eef99e7453f2d6ff4097c0c48e66b3
https://pubmed.ncbi.nlm.nih.gov/10614617

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