Zobrazeno 1 - 10 of 15 pro vyhledávání: '"N L, Reddy"'
1
10,5-(Iminomethano)-10,11-dihydro-5H-dibenzo[a,d]cycloheptene and derivatives. Potent PCP receptor ligands
Autor: R. E. Cotter, Robert N. McBurney, Eckard Weber, Kyle R. Gee, N. L. Reddy, John F. W. Keana, L.‐Y. Hu, M. R. Rhodes, P. Barmettler, P N Hamilton
Publikováno v: Journal of Medicinal Chemistry. 36:1938-1946
IDDC (3, 10,5-(iminomethano)-10,11-dihydro-5H-dibenzo[a,d]cycloheptene++ +) and a series of substituted derivatives were synthesized and evaluated in vitro for their ability to displace tritiated MK-801 ([3H]-2) from its specific binding site in guin
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b72ecc54db960ae109b0405661b54fb
https://doi.org/10.1021/jm00066a002
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7
Synthesis and pharmacological evaluation of N,N'-diarylguanidines as potent sodium channel blockers and anticonvulsant agents
Autor: Michael E. Perlman, T C Wolcott, Lu Zhang, David Berlove, Sharad Magar, Elizabeth Yost, N. L. Reddy, James B. Fischer, Graham J. Durant, Kathleen J. Burke-Howie, Wenhong Fan
Publikováno v: Journal of medicinal chemistry. 41(17)
Synthesis and structure-activity relationships (SAR) are described for a series of N,N'-diarylguanidines related to N-acenaphth-5-yl-N'-(4-methoxynaphth-1-yl)guanidine (3) as anticonvulsants through blockade of sodium channels. SAR studies on compoun
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8ad42acd7dba03dfc39249e5df67798
https://pubmed.ncbi.nlm.nih.gov/9703475
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8
In vitro neuroprotection by substituted guanidines with varying affinities for the N-methyl-D-aspartate receptor ionophore and for sigma sites
Autor: C J, Kirk, N L, Reddy, J B, Fischer, T C, Wolcott, A G, Knapp, R N, McBurney
Publikováno v: The Journal of pharmacology and experimental therapeutics. 271(2)
Radioligand binding techniques were used to determine the affinity of a series of substituted guanidine derivatives for 1) the binding site within the ion channel of the N-methyl-D-aspartate (NMDA) receptor, as defined by displacement of MK-801 ([3H]
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c3956ce488ac81ea18b84c830a9687fa
https://pubmed.ncbi.nlm.nih.gov/7525936
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9
Synthesis and structure-activity studies of N,N'-diarylguanidine derivatives. N-(1-naphthyl)-N'-(3-ethylphenyl)-N'-methylguanidine: a new, selective noncompetitive NMDA receptor antagonist
Autor: N L, Reddy, L Y, Hu, R E, Cotter, J B, Fischer, W J, Wong, R N, McBurney, E, Weber, D L, Holmes, S T, Wong, R, Prasad
Publikováno v: Journal of medicinal chemistry. 37(2)
Diarylguanidines, acting as NMDA receptor ion channel site ligands, represent a new class of potential neuroprotective drugs. Several diarylguanidines structurally related to N,N'-di-o-tolylguanidine (DTG), a known selective sigma receptor ligand, we
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::602313bfeb6738b725bccb5fd04b562d
https://pubmed.ncbi.nlm.nih.gov/8295213
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10
New CNS-specific calcium antagonists
Autor: R N, McBurney, D, Daly, J B, Fischer, L Y, Hu, K, Subbarao, A G, Knapp, K, Kobayashi, L, Margolin, N L, Reddy, S M, Goldin
Publikováno v: Journal of neurotrauma. 9
Ischemic insults to the brain in stroke or traumatic brain injury produce excessive release of glutamate from depolarized nerve terminals. This excessive glutamate release in turn stimulates massive calcium entry into nerve cells, activating a bioche
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a6b10a25ec9c731a3a374a627060480a
https://pubmed.ncbi.nlm.nih.gov/1319500
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