Antisense oligonucleotide gapmers containing phosphoryl guanidine groups reverse MDR1-mediated multiple drug resistance of tumor cells

Autor: O. A. Patutina, Dmitry A. Stetsenko, Elena L. Chernolovskaya, Marina A. Zenkova, N. L. Mironova, Anton V. Filatov, Ivan V. Chernikov, Dmitrii V. Pyshnyi, Maxim S. Kupryushkin, Sidney Altman, Valentin V. Vlassov

Publikováno v: Molecular Therapy. Nucleic Acids
Molecular Therapy: Nucleic Acids, Vol 27, Iss, Pp 211-226 (2022)

Antisense gapmer oligonucleotides containing phosphoryl guanidine (PG) groups, e.g., 1,3-dimethylimidazolidin-2-imine, at three to five internucleotidic positions adjacent to the 3′ and 5′ ends were prepared via the Staudinger chemistry, which is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9e66637a176c9251c315ae6ad4f92c9
https://doi.org/10.1016/j.omtn.2021.11.025

Human Recombinant DNase I (Pulmozyme®) Inhibits Lung Metastases in Murine Metastatic B16 Melanoma Model That Correlates with Restoration of the DNase Activity and the Decrease SINE/LINE and c-Myc Fragments in Blood Cell-Free DNA

Autor: Marina A. Zenkova, Aleksandra V Sen'kova, Ludmila Alekseeva, N. L. Mironova, Innokenty A. Savin

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 12074, p 12074 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 21

Tumor-associated cell-free DNAs (cfDNA) play an important role in the promotion of metastases. Previous studies proved the high antimetastatic potential of bovine pancreatic DNase I and identified short interspersed nuclear elements (SINEs) and long

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff2a20cef31fba8109a179ddae980f1f
https://www.mdpi.com/1422-0067/22/21/12074

Dual miRNases for Triple Incision of miRNA Target: Design Concept and Catalytic Performance

Autor: Marina A. Zenkova, Svetlana Gaponova, Valentin V. Vlassov, Daria Chiglintseva, O. A. Patutina, Elena V. Bichenkova, N. L. Mironova

Publikováno v: Molecules, Vol 25, Iss 2459, p 2459 (2020)
Patutina, O, Chiglintseva, D, Bichenkova, E, Gaponova, S, Mironova, N, Vlassov, V & Zenkova, M 2020, ' Dual miRNases for Triple Incision of miRNA Target: Design Concept and Catalytic Performance ', Molecules, vol. 25, no. 10, pp. 2459 . https://doi.org/10.3390/molecules25102459
Molecules
Volume 25
Issue 10

Irreversible destruction of disease-associated regulatory RNA sequences offers exciting opportunities for safe and powerful therapeutic interventions against human pathophysiology. In 2017, for the first time we introduced miRNAses&ndash
miRNA-t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae3b7ab056afc249b96edf0cb109e755
https://www.mdpi.com/1420-3049/25/10/2459

Role of Cell-Free DNA and Deoxyribonucleases in Tumor Progression

Autor: Ludmila Alekseeva, N. L. Mironova

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 12246, p 12246 (2021)
International Journal of Molecular Sciences

Many studies have reported an increase in the level of circulating cell-free DNA (cfDNA) in the blood of patients with cancer. cfDNA mainly comes from tumor cells and, therefore, carries features of its genomic profile. Moreover, tumor-derived cfDNA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbc2cef159d59ed3c5c4a4afe7a7b1bb
https://doi.org/10.3390/ijms222212246

The systemic tumor response to RNase A treatment affects the expression of genes involved in maintaining cell malignancy

Autor: Alexander Kurilshikov, O. A. Patutina, Evgenyi Brenner, N. L. Mironova, Marina A. Zenkova, Valentin V. Vlassov

Publikováno v: Oncotarget
Oncotarget, 8(45), 78796-78810. Impact Journals LLC

Recently, pancreatic RNase A was shown to inhibit tumor and metastasis growth that accompanied by global alteration of miRNA profiles in the blood and tumor tissue (Mironova et al., 2013). Here, we performed a whole transcriptome analysis of murine L

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0eecae93f0bb85cf4d52e6aa42b5de6f
https://doi.org/10.18632/oncotarget.20228