Zobrazeno 1 - 10
of 20
pro vyhledávání: '"N L, Kaplan"'
Publikováno v:
Genetic epidemiology. 20(2)
Tests of linkage and association between a disease and either a candidate gene or marker allele can be based on sibships with at least one affected and one unaffected sibling. However, specialized techniques are required to account for within-sibship
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3cf0b44ece652e45b5bb62f2b618da5a
https://pubmed.ncbi.nlm.nih.gov/11180445
https://pubmed.ncbi.nlm.nih.gov/11180445
Publikováno v:
Genetic epidemiology. 19(1)
Advances in marker technology have made a dense marker map a reality. If each marker is considered separately, and separate tests for association with a disease gene are performed, then multiple testing becomes an issue. A common solution uses a Bonf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::86eb7e7049c65323291e5d30a95553b7
https://pubmed.ncbi.nlm.nih.gov/10861894
https://pubmed.ncbi.nlm.nih.gov/10861894
Autor:
E R, Martin, N L, Kaplan
Publikováno v:
Genetic epidemiology. 18(1)
One strategy for mapping disease loci using marker-disease associations is to test for association with case-control samples and follow up a positive result with a family-based test. Using a family-based test in the second stage can help provide prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ea0fc55a2a6b52e7d5c91e6f40077301
https://pubmed.ncbi.nlm.nih.gov/10603458
https://pubmed.ncbi.nlm.nih.gov/10603458
Publikováno v:
Genetic epidemiology. 17
A two-stage approach was used to analyze Problem 2 simulated data from Genetic Analysis Workshop 11. In the first stage, we tested for linkage with the Haseman-Elston test in SIBPAL. Markers that were significant in the first stage were followed up w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d696d14c7d2d0caeacaf59dac0f18987
https://pubmed.ncbi.nlm.nih.gov/10597509
https://pubmed.ncbi.nlm.nih.gov/10597509
Publikováno v:
Genetic epidemiology. 14(6)
A permutation test is proposed for assessing affection status models. The test uses marker data from regions with prior evidence of linkage to susceptibility genes, and three different test statistics are examined. We applied the test to the GAW10 da
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5ed2630fc9fa5ca1f117b217d21f6731
https://pubmed.ncbi.nlm.nih.gov/9433563
https://pubmed.ncbi.nlm.nih.gov/9433563
Autor:
N. L. Kaplan, B. S. Weir
Publikováno v:
Progress in Population Genetics and Human Evolution ISBN: 9781441928566
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dfa4d0dd51fc1213d014f9404a023b3c
https://doi.org/10.1007/978-1-4757-2609-1_13
https://doi.org/10.1007/978-1-4757-2609-1_13
Autor:
Richard R. Hudson, N L Kaplan
An analytic expression for the expected nucleotide diversity is obtained for a neutral locus in a region with deleterious mutation and recombination. Our analytic results are used to predict levels of variation for the entire third chromosome of Dros
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1ac0fd0b3690b0b6e57d2dc051cdc48
https://europepmc.org/articles/PMC1206891/
https://europepmc.org/articles/PMC1206891/
Autor:
N L, Kaplan, B S, Weir
Publikováno v:
American journal of human genetics. 57(6)
In the past several years, allelic association has helped map a number of rare genetic diseases in the human genome. A commonly used upper bound on the recombination fraction between the disease gene and an associated marker is known to be biased dow
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::625834f31495f59e0c2f51e8485ec606
https://pubmed.ncbi.nlm.nih.gov/8533779
https://pubmed.ncbi.nlm.nih.gov/8533779
The level of DNA sequence variation is reduced in regions of the Drosophila melanogaster genome where the rate of crossing over per physical distance is also reduced. This observation has been interpreted as support for the simple model of genetic hi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab90621d862890f351a78faf307ee062
https://europepmc.org/articles/PMC1206652/
https://europepmc.org/articles/PMC1206652/
Publikováno v:
American journal of human genetics. 56(1)
Until recently, attempts to map disease genes on the basis of population associations with linked markers have been based on expected values of linkage disequilibrium. These methods suffer from the large variances imposed on disequilibrium measures b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::71986f6cea0a1e77806d20a0265a5a7b
https://pubmed.ncbi.nlm.nih.gov/7825565
https://pubmed.ncbi.nlm.nih.gov/7825565