Zobrazeno 1 - 10
of 31
pro vyhledávání: '"N L, Harrison"'
Publikováno v:
Annals of the Rheumatic Diseases. 79:1659.2-1659
Background:Cardiac conduction defects are well-documented in axial spondyloarthritis. However, historical literature (many from an era when axSpA was less well managed compared to modern day) include patients with advanced disease that may explain th
Publikováno v:
Annals of the Rheumatic Diseases. 79:1147.2-1147
Background:Social isolation has negative impacts on health and wellbeing at different stages of life. It is associated with longer sickness absence and increased mortality in the general population [1]. Reducing social isolation is a growing governme
Publikováno v:
Annals of the Rheumatic Diseases. 79:755.1-755
Background:Comorbidities are common among patients with axial spondyloarthritis (axSpA). The majority of axSpA patients have at least one comorbid medical condition in addition to any extra-articular manifestations [1]. Comorbidity ‘burden’ is as
Autor:
G. Talukder, N. L. Harrison
Publikováno v:
Journal of Neurophysiology. 73:73-79
1. The mechanisms of Zn2+ modulation of transient outward current (TOC) were studied in cultured rat hippocampal neurons, using the voltage-clamp technique. In the presence of micromolar concentrations of external Zn2+, the voltage dependence of acti
Autor:
G E, Homanics, F P, Elsen, S-W, Ying, A, Jenkins, C, Ferguson, B, Sloat, S, Yuditskaya, P A, Goldstein, J E, Kralic, A L, Morrow, N L, Harrison
Publikováno v:
Genes, brain, and behavior. 4(1)
In mammalian species, inhibition in the brain is mediated predominantly by the activation of GABAA receptors. We report here changes in inhibitory synaptic function and behavior in a mouse line harboring a gain-of-function mutation at Serine 270 (S27
Autor:
R, Lingamaneni, M D, Krasowski, A, Jenkins, T, Truong, A L, Giunta, J, Blackbeer, M B, MacIver, N L, Harrison, H C, Hemmings
Publikováno v:
Anesthesiology. 94(6)
Positive modulation of gamma-aminobutyric acid type A (GABAA) receptor function is recognized as an important component of the central nervous system depressant effects of many general anesthetics, including propofol. The role for GABAA receptors as
Publikováno v:
Neuroscience letters. 293(3)
Tryptophan substitutions were made in the second transmembrane domain of the gamma-aminobutyric acid(A) (GABA(A)) receptor alpha and beta subunits and the resulting mutant receptors, containing alpha(2)(S270W) and/or beta(1)(S265W), were expressed in
Autor:
L A, Hansen, N L, Harrison
Publikováno v:
Journal of the American Veterinary Medical Association. 216(9)
Autor:
M D, Krasowski, N L, Harrison
Publikováno v:
British journal of pharmacology. 129(4)
The actions of 13 general anaesthetics (diethyl ether, enflurane, isoflurane, methoxyflurane, sevoflurane, chloral hydrate, trifluoroethanol, tribromoethanol, tert-butanol, chloretone, brometone, trichloroethylene, and alpha-chloralose) were studied
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 284(3)
The actions of 2,2,2,-trichloroethanol were studied on agonist-activated Cl- currents in gamma-aminobutyric acid type A (GABAA), glycine and GABA rho 1 receptors by use of the whole-cell patch-clamp technique. Recombinant wild-type and mutant recepto