Zobrazeno 1 - 10
of 37
pro vyhledávání: '"N L, Esmon"'
Publikováno v:
Blood. 94:3839-3846
In this study, we test the hypothesis that prothrombin levels may modulate activated protein C (APC) anticoagulant activity. Prothrombin in purified systems or plasma dramatically inhibited the ability of APC to inactivate factor Va and to anticoagul
Autor:
Koen Mertens, Raymond Klein Gebbink, Hans Pannekoek, N L Esmon, Hartmut J. Ehrlich, Jaap Keijer, Klaus T. Preissner
Publikováno v:
The Journal of Cell Biology
Vitronectin endows plasminogen activator inhibitor 1 (PAI-1), the fast-acting inhibitor of both tissue-type plasminogen activator (t-PA) and urokinase-type plasminogen activator (u-PA), with additional thrombin inhibitory properties. In view of the a
Activated protein C (APC) anticoagulant activity and the ability to be inhibited by auto-antibodies associated with thrombosis are strongly augmented by the presence of phosphatidylethanolamine (PE) and phospholipid oxidation. β2-glycoprotein I (β2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::830f4ba1518f94b3182044f91f9c78c1
https://europepmc.org/articles/PMC1895229/
https://europepmc.org/articles/PMC1895229/
Publikováno v:
The Journal of rheumatology. 27(2)
To test the hypothesis that thrombomodulin (TM) may be a target for lupus anticoagulant (LAC) antibodies.A recombinant soluble form of TM was produced and used as an antigen for an ELISA to detect antibodies to TM (TMAB). Sixty-one samples from 58 pa
Autor:
C T, Esmon, J, Xu, J M, Gu, D, Qu, Z, Laszik, G, Ferrell, D J, Stearns-Kurosawa, S, Kurosawa, F B, Taylor, N L, Esmon
Publikováno v:
Thrombosis and haemostasis. 82(2)
Publikováno v:
Blood. 94(11)
In this study, we test the hypothesis that prothrombin levels may modulate activated protein C (APC) anticoagulant activity. Prothrombin in purified systems or plasma dramatically inhibited the ability of APC to inactivate factor Va and to anticoagul
Publikováno v:
Haematologica. 84(5)
Although lupus anticoagulants (LAs) are immunoglobulins that inhibit procoagulant reactions in vitro, these molecules are associated with thrombosis in vivo. We and others have hypothesized that this may be due to selective targeting of the activated
Publikováno v:
The Journal of biological chemistry. 274(9)
The effect of replacing the gamma-carboxyglutamic acid domain of activated protein C (APC) with that of prothrombin on the topography of the membrane-bound enzyme was examined using fluorescence resonance energy transfer. The average distance of clos
Autor:
C T, Esmon, W, Ding, K, Yasuhiro, J M, Gu, G, Ferrell, L M, Regan, D J, Stearns-Kurosawa, S, Kurosawa, T, Mather, Z, Laszik, N L, Esmon
Publikováno v:
Thrombosis and haemostasis. 78(1)
Publikováno v:
Thrombosis and haemostasis. 78(1)
These studies indicate how immunoglobulin populations that react with phospholipid surfaces in the absence of other cofactor molecules can selectively inhibit anticoagulant pathways and lead to a prothrombotic state. These studies combined with those