Zobrazeno 1 - 10
of 368
pro vyhledávání: '"N Krasner"'
Autor:
Richard T Penson, Allison J Ambrosio, Christin A Whalen, Carolyn N Krasner, Panagiotis A Konstantinopoulos, Charles Bradley, Ursula A Matulonis, Michael J Birrer
Publikováno v:
The Oncologist. 28:252-257
Background Iniparib (BSI-201), a novel anticancer agent thought to have poly(ADP-ribose) polymerase (PARP) inhibitory activity and synergy with both gemcitabine and carboplatin (GC) was evaluated in 2 cohorts with GC. Methods Parallel multicenter, si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca75460012ab9d89ca8386a0b654330e
https://doi.org/10.1093/oncolo/oyac275
https://doi.org/10.1093/oncolo/oyac275
Autor:
Shruti Gupta, Paul E Hanna, Tianqi Ouyang, Karla Sofia Yamada, Rani Sawtell, Qiyu Wang, Nurit Katz-Agranov, Lea Feghali, Carolyn N Krasner, Sara Bouberhan, Cesar M Castro, Meghan E Sise
Publikováno v:
JNCI: Journal of the National Cancer Institute.
Background Poly (ADP-ribose) polymerase inhibitors (PARPi) have revolutionized the treatment of ovarian cancer; however, real-world data on kidney function among patients treated with PARPi are lacking. Methods We identified adults treated with olapa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::31438364419ded1d9893b1f942147072
https://doi.org/10.1093/jnci/djad070
https://doi.org/10.1093/jnci/djad070
Autor:
Chantay L. Young, Karan R. Chadda, Ursula A. Matulonis, Hang Lee, Susana M. Campos, Antonella M. D'Ascanio, Richard T. Penson, Michael J. Birrer, Panagiotis A. Konstantinopoulos, Carolyn N. Krasner, Neil S. Horowitz
Publikováno v:
Gynecologic Oncology. 162:661-666
Background Topoisomerase-1 inhibitors are an important class of cytotoxics associated with toxicity that limits their use. CRLX101 is a novel cyclodextrin-containing polymer conjugate of camptothecin (CPT) that self-assembles into nanoparticles to de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::949218174c36583eb96d7e937aadb1e7
https://doi.org/10.1016/j.ygyno.2021.07.002
https://doi.org/10.1016/j.ygyno.2021.07.002
Autor:
Neil S. Horowitz, Panagiotis A. Konstantinopoulos, Stephanie Morrissey, Roxanne Quinn, Carolyn N. Krasner, Ursula A. Matulonis, Alexi A. Wright, Jennifer Taylor Veneris, Nabihah Tayob, Susan Schumer, Niya Xiong, Gabriela West, Joyce F. Liu, Susana M. Campos
Publikováno v:
Journal of Clinical Oncology. 39:1531-1539
PURPOSEUterine serous carcinoma (USC) is a distinct histologic subtype of endometrial cancer, with molecular characteristics suggesting frequent cell-cycle dysregulation paired with a high level of oncogene-driven replication stress. Adavosertib is a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c87232c0a132c486b2b9ab187e68684
https://doi.org/10.1200/jco.20.03167
https://doi.org/10.1200/jco.20.03167
Autor:
Premal H. Thaker, Susan C. Modesitt, Christopher Purdy, Carolyn N. Krasner, Russell J. Schilder, Cara Mathews, David M. O'Malley, William C. Zamboni, Linda R. Duska, Anthony B. Miller, Kathleen N. Moore, A.T. Lucas, John L. Hays, Jeffrey G. Supko
Publikováno v:
Gynecologic Oncology. 160:688-695
Background: EP0057 (formerly CRLX101) is an investigational nanoparticle-drug conjugate (NDC) of a cyclodextrin-based polymer backbone plus camptothecin, a topoisomerase-1 inhibitor. Prior studies showed efficacy in recurrent or persistent, epithelia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61e2717caf22fe578c677881ed194fec
https://doi.org/10.1016/j.ygyno.2020.12.025
https://doi.org/10.1016/j.ygyno.2020.12.025
Autor:
Panagiotis A. Konstantinopoulos, Alexi A. Wright, Christin Whalen, Neil S. Horowitz, Roxanne Quinn, Carolyn N. Krasner, Elizabeth H. Stover, Susana M. Campos, Ursula A. Matulonis, Su-Chun Cheng, Mark A. Hoffman, Joyce F. Liu, Elizabeth K. Lee, Don S. Dizon, Richard T. Penson, William T. Barry, Stephanie Morrissey, Niya Xiong
Publikováno v:
Gynecologic Oncology. 159:72-78
Objective Pegylated liposomal doxorubicin (PLD) in vitro may have immunomodulatory abilities and preclinical evidence suggests it synergizes with immune checkpoint blockade. We hypothesized that combining PLD and pembrolizumab would be active in pati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ac7b465199e357f0032e8cc24a401e4
https://doi.org/10.1016/j.ygyno.2020.07.028
https://doi.org/10.1016/j.ygyno.2020.07.028
Autor:
Susana M. Campos, Suzanne Berlin, Carolyn N. Krasner, Christin Whalen, Tina Atkinson, Kristin Meegan, Lauren Pereira, Karin Tyburski, Weixiu Lou, Hang Lee, Neil Horowitz, Richard T. Penson
Publikováno v:
Cancer chemotherapy and pharmacology. 89(3)
Temsirolimus, a mTOR inhibitor, and AZD2171, a VEGFR inhibitor, have independently shown activity in patients with gynecological malignancies. Understanding the pivotal role of the PI3K/PTEN/AKT/mTOR pathway in regulating angiogenesis, a phase I stud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::857e5ee32f54cfb6ff73892147ab078d
https://pubmed.ncbi.nlm.nih.gov/35142863
https://pubmed.ncbi.nlm.nih.gov/35142863
Autor:
Heather Crowe, Susan Schumer, Elizabeth H. Stover, Jennifer Curtis, Ursula A. Matulonis, Jeffrey J. Ishizuka, Alexi A. Wright, Neal I. Lindeman, Christin Whalen, Mary K. Buss, Whitfield B. Growdon, Sarah J. Hill, Roxanne Quinn, Carolyn N. Krasner, Allison Gockley, Stephen A. Cannistra, Doga Gulhan, Gini F. Fleming, Kathryn P. Gray, Weixiu Luo, Joyce F. Liu, Richard T. Penson, Panagiotis A. Konstantinopoulos, Susana M. Campos
Publikováno v:
J Clin Oncol
PURPOSE Despite the tissue-agnostic approval of pembrolizumab in mismatch repair deficient (MMRD) solid tumors, important unanswered questions remain about the role of immune checkpoint blockade in mismatch repair–proficient (MMRP) and –deficient
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e16d507ac6cd36e4f078d47204cd7742
https://doi.org/10.1200/jco.19.01021
https://doi.org/10.1200/jco.19.01021
Publikováno v:
Current Problems in Cancer. 43:443-449
An 83-year-old woman presented with postmenopausal bleeding ultimately leading to surgery and a final diagnosis of stage IB grade 3 endometrioid endometrial adenocarcinoma. The tumor board reviewed current literature regarding the efficacy of sentine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d6d563bf121b49023bf3f066a02227fd
https://doi.org/10.1016/j.currproblcancer.2019.01.006
https://doi.org/10.1016/j.currproblcancer.2019.01.006
Autor:
Niya Xiong, Margaret M. Dinardo, Susan Schumer, Neil S. Horowitz, Panagiotis A. Konstantinopoulos, Carolyn N. Krasner, Ursula A. Matulonis, Embree Thompson, Elizabeth Schrier, Susana M. Campos, Nabihah Tayob, Alexi A. Wright, Colleen M. Feltmate, Hanneke Poort, Mitesh S. Patel, Joyce F. Liu
Publikováno v:
Gynecologic Oncology, 161, 581-586
Gynecologic Oncology, 161, 2, pp. 581-586
Gynecologic Oncology, 161, 2, pp. 581-586
Contains fulltext : 245974.pdf (Publisher’s version ) (Closed access) OBJECTIVE: Physical activity improves physical function, quality of life, and mental health, yet fewer than 80% of ovarian cancer survivors meet activity guidelines. This pilot i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::805b465fb44337fab969fb445de23c14
https://pubmed.ncbi.nlm.nih.gov/33637350
https://pubmed.ncbi.nlm.nih.gov/33637350