Výsledky vyhledávání

Akademický článek

Mesenchymal stem cell secretome reduces pain and prevents cartilage damage in a murine osteoarthritis model

Autor: S Khatab, GJVM van Osch, N Kops, YM Bastiaansen-Jenniskens, PK Bos, JAN Verhaar, MR Bernsen, GM van Buul

Publikováno v: European Cells & Materials, Vol 36, Pp 218-230 (2018)

Mesenchymal stem cells (MSCs) represent a promising biological therapeutic option as an osteoarthritis (OA)-modifying treatment. MSCs secrete factors that can counteract inflammatory and catabolic processes and attract endogenous repair cells. The ef

Externí odkaz: https://doaj.org/article/f33b6103552743f9ad5f879cca2bc49d

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Akademický článek

The in vitro and in vivo capacity of culture-expanded human cells from several sources encapsulated in alginate to form cartilage

Autor: MM Pleumeekers, L Nimeskern, WLM Koevoet, N Kops, RML Poublon, KS Stok, GJVM van Osch

Publikováno v: European Cells & Materials, Vol 27, Pp 264-280 (2014)

Cartilage has limited self-regenerative capacity. Tissue engineering can offer promising solutions for reconstruction of missing or damaged cartilage. A major challenge herein is to define an appropriate cell source that is capable of generating a st

Externí odkaz: https://doaj.org/article/093d9ed0aeba41cc8c02ea03c325e062

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Akademický článek

Chondrogenically differentiated mesenchymal stromal cell pellets stimulate endochondral bone regeneration in critical-sized bone defects

Autor: J van der Stok, MKE Koolen, H Jahr, N Kops, JH Waarsing, H Weinans, OP van der Jagt

Publikováno v: European Cells & Materials, Vol 27, Pp 137-148 (2014)

Grafting bone defects or atrophic non-unions with mesenchymal stromal cells (MSCs)-based grafts is not yet successful. MSC-based grafts typically use undifferentiated or osteogenically differentiated MSCs and regenerate bone through intramembranous o

Externí odkaz: https://doaj.org/article/d2e26d6e6c8d40de956777fb067a98e6

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Akademický článek

Chondrogenic differentiation of human bone marrow-derived mesenchymal stem cells in a simulated osteochondral environment is hydrogel dependent

Autor: ML de Vries-van Melle, MS Tihaya, N Kops, WJLM Koevoet, JM Murphy, JAN Verhaar, M Alini, D Eglin, GJVM van Osch

Publikováno v: European Cells & Materials, Vol 27, Pp 112-123 (2014)

Hydrogels pose interesting features for cartilage regeneration strategies, such as the option for injectability and in situ gelation resulting in optimal filling of defects. We aimed to study different hydrogels for their capability to support chondr

Externí odkaz: https://doaj.org/article/b91e3e32097840dc98fcf948077da3f1

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Akademický článek

PLOD2 gene expression in infrapatellar fat pad is correlated with fat mass in obese patients with end-stage knee osteoarthritis

Autor: J. Van den Langenbergh, Y.M. Bastiaansen-Jenniskens, G.J.V.M. van Osch, J. Runhaar, S.M.A. Bierma-Zeinstra, K. Soballe, J. Laursen, A. Liljensoe, N. Kops, I. Mechlenburg, S. Clockaerts

Publikováno v: Osteoarthritis and Cartilage Open, Vol 6, Iss 2, Pp 100469- (2024)

Objective: To investigate associations between obesity-linked systemic factors and gene expression indicative for the inflammatory and fibrotic processes in the infrapatellar fat pad (IFP), in a population of obese patients with end-stage knee osteoa

Externí odkaz: https://doaj.org/article/c60f00f4270c40db94fc929567e990a2

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Akademický článek

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A new semi-orthotopic bone defect model for cell and biomaterial testing in regenerative medicine

Autor: C Intini, Eric Farrell, G.J.V.M. (Gerjo) van Osch, I Jansen, Eppo B. Wolvius, Janneke Witte-Bouma, Sandra Hofmann, E Andrés Sastre, Y Nossin, Yanto Ridwan, John P. Gleeson, Fergal J. O'Brien, N Kops, B. van Rietbergen

Publikováno v: Biomaterials, 279. Elsevier
Biomaterials, 279:121187. Elsevier
Biomaterials, 279
Biomaterials

In recent decades, an increasing number of tissue engineered bone grafts have been developed. However, expensive and laborious screenings in vivo are necessary to assess the safety and efficacy of their formulations. Rodents are the first choice for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26370e021f4df9303c41a5e10f18925b
https://pure.eur.nl/en/publications/72805e7b-58d0-4e9d-9a5c-66615b722e34