Zobrazeno 1 - 10
of 38
pro vyhledávání: '"N K Green"'
Publikováno v:
Molecular Therapy Oncolytics
Molecular Therapy: Oncolytics, Vol 4, Iss C, Pp 55-66 (2017)
Molecular Therapy: Oncolytics, Vol 4, Iss C, Pp 55-66 (2017)
Effective therapeutics for ovarian cancer continue to be urgently needed, particularly for chemotherapy-resistant cases. Here we present both a 3D-Matrigel culture-based expansion of our directed evolution method for generation of oncolytic virothera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f30c5045b244be218b4fa08898ecaa1b
https://doi.org/10.1016/j.omto.2016.12.001
https://doi.org/10.1016/j.omto.2016.12.001
Autor:
Jordan Turnbull, Bernice Wright, Iwan Roberts, Oliver Hardick, Daniel G. Bracewell, R Tarrant, N K Green
Publikováno v:
Biotechnology and bioengineering. 116(7)
Viral vectors such as adenovirus have successful applications in vaccines and gene therapy but the manufacture of the high-quality virus remains a challenge. It is desirable to use the adsorption-based chromatographic separations that so effectively
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24488b3528592b6d58ac0ad29ddf27f0
https://pubmed.ncbi.nlm.nih.gov/30883678
https://pubmed.ncbi.nlm.nih.gov/30883678
Autor:
Veronique Bachy, Leonard W. Seymour, N K Green, Joanne Morrison, David R. Greaves, Linda S. Klavinskis, Patricia Seaton, C Thoma
Publikováno v:
Virology. 447(1-2):74-83
In a phase II/III clinical trial intraperitoneal (i.p.) administration of a group C adenovirus vector (Ad5) caused bowel adhesion formation, perforation and obstruction. However, we had found that i.p. group B, in contrast to group C adenoviruses, di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e688168a551adf884e50e6902fca6c23
Adenovirus provides many opportunities as a vector for delivery of cytotoxic genes to tumours. Polymer coating of adenovirus is known to increase its plasma circulation kinetics, affording the possibility of active and passive targeting to tumours. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37ed42d0cdb1367f7e7066ab26b5f36c
https://ora.ox.ac.uk/objects/uuid:f51b21c4-2c91-459b-81c4-3266998246bc
https://ora.ox.ac.uk/objects/uuid:f51b21c4-2c91-459b-81c4-3266998246bc
Autor:
Joanne R. Flavell, Vivien Mautner, Peter F. Searle, N K Green, David J. Kerr, Ming-Jen Chen, Gary M. Reynolds, Lawrence S. Young
Viruses that replicate selectively in cancer cells constitute an exciting new class of anticancer agent. The conditionally replicating adenovirus (CRAd) dl1520, which lacks the E1B-55K gene, has elicited significant clinical responses in humans when
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8ff5bb6fd6adcd37506a549b0e2bb09
https://ora.ox.ac.uk/objects/uuid:66ffa398-2ef2-4ae3-b8a4-2ce1ee35596c
https://ora.ox.ac.uk/objects/uuid:66ffa398-2ef2-4ae3-b8a4-2ce1ee35596c
Publikováno v:
Methods in Molecular Biology ISBN: 9781493930074
Replication-deficient adenoviruses are potent vaccine development platforms used extensively for human and animal candidate vaccines, largely due to their very good safety and immunogenicity profile. In this chapter we describe a method that can be u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::257e425f72130f641636913a751bcda0
https://doi.org/10.1007/978-1-4939-3008-1_8
https://doi.org/10.1007/978-1-4939-3008-1_8
Autor:
Andreas F.-P. Sonnen, N K Green, Anna M. Cerny, Leonard W. Seymour, Kerry D. Fisher, Robert B. Sim, Vladimir Subr, Robert J.C. Gilbert, Y Di, Robert W. Finberg, Karel Ulbrich, Robert Carlisle
Publikováno v:
Blood
Type 5 adenovirus (Ad5) is a human pathogen that has been widely developed for therapeutic uses, with only limited success to date. We report here the novel finding that human erythrocytes present Coxsackie virus-adenovirus receptor (CAR) providing a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aff0399378b98bf1bcbdf5181ac264a9
https://doi.org/10.1182/blood-2008-09-178459
https://doi.org/10.1182/blood-2008-09-178459
Autor:
Leonard W. Seymour, Joanne Morrison, N K Green, Kerry D. Fisher, Simon S. Briggs, Karel Ulbrich, Sean Kehoe, Vladimir Subr
Publikováno v:
Molecular Therapy. 16(2):244-251
Adenovirus gene therapy for intraperitoneal (IP) cancer is limited in clinical trials by inefficient tumor cell transduction and development of peritoneal adhesions. We have shown previously that normal virus tropism can be ablated by physically shie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef43dd19b4831ac6292491382ec5ce1c
Autor:
J. G. Young, N K Green, Peter F. Searle, Vivien Mautner, Lawrence S. Young, Nicholas D. James
Publikováno v:
Prostate Cancer and Prostatic Diseases. 11:187-193
The nitroreductase (NR)/CB1954 enzyme prodrug system has given promising results in pre-clinical studies and is currently being assessed in phase I and II clinical trials in prostate cancer. Enhanced cell killing by apparent immune-mediated mechanism
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c87cfcdd1249b7cec4dff2801a980ddf
https://doi.org/10.1038/sj.pcan.4501008
https://doi.org/10.1038/sj.pcan.4501008
Autor:
E Boos, A B Hale, N. van Rooijen, Mark Stevenson, Vivien Mautner, Leonard W. Seymour, C Herbert, Kerry D. Fisher, M Lyons, N K Green, L Chandler, Karel Ulbrich
Publikováno v:
Gene Therapy. 13:356-368
Non-human adenovirus vectors have attractive immunological properties for gene therapy but are frequently restricted by inefficient transduction of human target cells. Using chicken embryo lethal orphan (CELO) virus, we employed a nongenetic mechanis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cc2027540ebbbfaf5dc91a6513d932c
https://doi.org/10.1038/sj.gt.3302655
https://doi.org/10.1038/sj.gt.3302655