Zobrazeno 1 - 6
of 6
pro vyhledávání: '"N K Collins"'
Autor:
Pamela E. Blackshear, Barbara J. Davis, Powel H. Brown, L M Bennett, Donna O. Bunch, N K Collins, Kimberly A. McAllister, Julie F. Foley, Roger W. Wiseman, Susan M. Goldsworthy
Publikováno v:
Oncogene. 16:61-68
The mouse homologues of the breast cancer susceptibility genes, Brca1 and Brca2, are expressed in a cell cycle-dependent fashion in vitro and appear to be regulated by similar or overlapping pathways. Therefore, we compared the non isotopic in situ h
Autor:
L M, Bennett, K A, McAllister, P E, Blackshear, J, Malphurs, G, Goulding, N K, Collins, T, Ward, D O, Bunch, E M, Eddy, B J, Davis, R W, Wiseman
Publikováno v:
Molecular carcinogenesis. 28(3)
Women who inherit mutations in the BRCA2 cancer susceptibility gene have an 85% chance of developing breast cancer. The function of the BRCA2 gene remains elusive, but there is evidence to support its role in transcriptional transactivation, tumor su
Autor:
L M, Bennett, K A, McAllister, J, Malphurs, T, Ward, N K, Collins, J C, Seely, L C, Gowen, B H, Koller, B J, Davis, R W, Wiseman
Publikováno v:
Cancer research. 60(13)
Women who inherit mutations in the breast cancer susceptibility genes, BRCA1 and BRCA2, are predisposed to the development of breast and ovarian cancer. We used mice with a Brca1 mutation on a BALB/cJ inbred background (BALB/cB1+/- mice) or a Brca2 g
Autor:
Kimberly A. McAllister, N K Collins, K-U Wagner, Roger W. Wiseman, Edward M. Eddy, G Goulding, Jason Malphurs, Toni Ward, L M Bennett, Barbara J. Davis
Publikováno v:
Breast Cancer Research. 2
BRCA2 hereditary gene mutations confer a profound predisposition to breast cancer in women. We have generated mice carrying a Cre-loxP conditional Erca2 mutated allele by flanking exon 27 with loxP sites and we predict that this will disrupt basic fu
Autor:
K A, McAllister, A, Haugen-Strano, S, Hagevik, H A, Brownlee, N K, Collins, P A, Futreal, L M, Bennett, R W, Wiseman
Publikováno v:
Cancer research. 57(15)
Inherited BRCA2 mutations confer profound susceptibility to human breast and ovarian cancer. The rat and mouse Brca2 homologues share 58% and 59% identity (72% similarity), respectively, with the human BRCA2 protein. The Brca2 proteins also share a p
Autor:
T, Fujino, J I, Risinger, N K, Collins, F S, Liu, H, Nishii, H, Takahashi, E M, Westphal, J C, Barrett, H, Sasaki, M F, Kohler
Publikováno v:
Cancer research. 54(16)
An allelotype analysis of endometrial carcinoma was undertaken to identify chromosomal loci that are relevant to this tumor type. A total of 70 highly polymorphic microsatellite markers, distributed among all nonacrocentric chromosome arms, were exam